UniProt P28222
5-hydroxytryptamine receptor 1B (P28222)
5-hydroxytryptamine receptor 1B (UniProt P28222): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P28222
- Protein
- 5-hydroxytryptamine receptor 1B
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 8 · 2 records with a druggable one
Structures
10 records of P28222 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4IAQ | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI… | x-ray diffraction | A | — | — |
| 4IAQ | Crystal structure of the chimeric protein of 5-HT1B-bril in complex with dihydroergotamine (psi… | x-ray diffraction | A | — | — |
| 4IAR | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community… | x-ray diffraction | A | — | — |
| 4IAR | Crystal structure of the chimeric protein of 5-HT1B-bril in complex with ergotamine (psi community… | x-ray diffraction | A | — | — |
| 5V54 | Crystal structure of 5-HT1B receptor in complex with methiothepin | x-ray diffraction | A, B | 89F | — |
| 6G79 | Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor | electron microscopy | S | EP5 | 3 (best 0.75) |
| 6G79 | Coupling specificity of heterotrimeric go to the serotonin 5-HT1B receptor | electron microscopy | S | EP5 | — |
| 7C61 | Crystal structure of 5-HT1B-BRIL and SRP2070_Fab complex | x-ray diffraction | A | ERM | 5 (best 0.79) |
| 7C61 | Crystal structure of 5-HT1B-bril and SRP2070_FAB complex | x-ray diffraction | A | ERM | — |
| P28222 | AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 1B (P28222) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6G79 chain S against the predicted model P28222: TM-score 0.94, RMSD 1.94 Å
- 6G79 chain S against the predicted model P28222: TM-score 0.94, RMSD 1.94 Å
- 4IAQ chain A against the predicted model P28222: TM-score 0.80, RMSD 2.17 Å
- 4IAQ chain A against the predicted model P28222: TM-score 0.80, RMSD 2.17 Å
- 7C61 chain A against the predicted model P28222: TM-score 0.78, RMSD 2.60 Å
- 7C61 chain A against the predicted model P28222: TM-score 0.78, RMSD 2.60 Å
- 5V54 chain B against the predicted model P28222: TM-score 0.78, RMSD 2.80 Å
- 4IAR chain A against the predicted model P28222: TM-score 0.77, RMSD 3.00 Å
- 4IAR chain A against the predicted model P28222: TM-score 0.77, RMSD 3.00 Å
- 4IAR chain A against the predicted model P0ABE7: TM-score 0.28, RMSD 2.97 Å
Elsewhere
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