UniProt P27487
Dipeptidyl peptidase 4 (P27487)
Dipeptidyl peptidase 4 (UniProt P27487), EC 3.4.14.5: 196 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 81 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P27487
- Protein
- Dipeptidyl peptidase 4
- EC
- 3.4.14.5
- Experimental structures
- 196
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 81 · 5 records with a druggable one
Structures
197 records of P27487 in the MolNFT archive: 196 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1J2E | Crystal structure of Human Dipeptidyl peptidase IV | x-ray diffraction | A, B | — | — |
| 1J2E | Crystal structure of human dipeptidyl peptidase IV | x-ray diffraction | A, B | — | — |
| 1N1M | Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor | x-ray diffraction | A, B | — | — |
| 1N1M | Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor | x-ray diffraction | A, B | — | — |
| 1NU6 | Crystal structure of human Dipeptidyl Peptidase IV (DPP-IV) | x-ray diffraction | A, B | — | — |
| 1NU6 | Crystal structure of human dipeptidyl peptidase IV (dpp-IV) | x-ray diffraction | A, B | — | — |
| 1NU8 | Crystal structure of human dipeptidyl peptidase IV (DPP-IV) in complex with Diprotin A (IPI) | x-ray diffraction | A, B | — | — |
| 1NU8 | Crystal structure of human dipeptidyl peptidase IV (dpp-IV) in complex with diprotin a (ipi) | x-ray diffraction | A, B | — | — |
| 1PFQ | crystal structure of human apo dipeptidyl peptidase IV / CD26 | x-ray diffraction | A, B | — | — |
| 1PFQ | Crystal structure of human apo dipeptidyl peptidase IV / CD26 | x-ray diffraction | A, B | — | — |
| 1R9M | Crystal Structure of Human Dipeptidyl Peptidase IV at 2.1 Ang. Resolution. | x-ray diffraction | A, B, C, D | — | — |
| 1R9M | Crystal structure of human dipeptidyl peptidase IV at 2.1 ang. resolution. | x-ray diffraction | A, B, C, D | — | — |
| 1R9N | Crystal Structure of human dipeptidyl peptidase IV in complex with a decapeptide (tNPY) at 2.3 Ang.… | x-ray diffraction | A, B, C, D | — | — |
| 1R9N | Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide (tnpy) at 2.3 ang.… | x-ray diffraction | A, B, C, D | — | — |
| 1RWQ | Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy… | x-ray diffraction | A, B | — | — |
| 1RWQ | Human dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4… | x-ray diffraction | A, B | — | — |
| 1TK3 | Crystal Structure Of Human Apo Dipeptidyl Peptidase IV/CD26 | x-ray diffraction | A, B | — | — |
| 1TK3 | Crystal structure of human apo dipeptidyl peptidase IV/CD26 | x-ray diffraction | A, B | — | — |
| 1TKR | Human Dipeptidyl Peptidase IV/CD26 inhibited with Diisopropyl FluoroPhosphate | x-ray diffraction | A, B | — | — |
| 1TKR | Human dipeptidyl peptidase IV/CD26 inhibited with diisopropyl fluorophosphate | x-ray diffraction | A, B | — | — |
| 1U8E | Human dipeptidyl peptidase IV/CD26 mutant Y547F | x-ray diffraction | A, B | — | — |
| 1U8E | Human dipeptidyl peptidase IV/CD26 mutant Y547F | x-ray diffraction | A, B | — | — |
| 1W1I | Crystal structure of dipeptidyl peptidase IV (DPPIV or CD26) in complex with adenosine deaminase | x-ray diffraction | A, B, C, D | — | — |
| 1W1I | Crystal structure of dipeptidyl peptidase IV (dppiv or CD26) in complex with adenosine deaminase | x-ray diffraction | A, B, C, D | — | — |
| 1WCY | Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A | x-ray diffraction | A, B | — | — |
| 1WCY | Crystal structure of human dipeptidyl peptidase IV (dppiv) complex with diprotin a | x-ray diffraction | A, B | — | — |
| 1X70 | Human dipeptidyl peptidase IV in complex with a beta amino acid inhibitor | x-ray diffraction | A, B | — | — |
| 1X70 | Human dipeptidyl peptidase IV in complex with a beta amino acid inhibitor | x-ray diffraction | A, B | — | — |
| 2AJL | X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor | x-ray diffraction | I, J | — | — |
| 2AJL | X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitor | x-ray diffraction | I, J | — | — |
| 2BGN | HIV-1 Tat protein derived N-terminal nonapeptide Trp2-Tat(1-9) bound to the active site of… | x-ray diffraction | A, B, C, D | — | — |
| 2BGN | HIV-1 tat protein derived N-terminal nonapeptide TRP2-TAT(1-9) bound to the active site of… | x-ray diffraction | A, B, C, D | — | — |
| 2BGR | Crystal structure of HIV-1 Tat derived nonapeptides Tat(1-9) bound to the active site of Dipeptidyl… | x-ray diffraction | A, B | — | — |
| 2BGR | Crystal structure of HIV-1 tat derived nonapeptides TAT(1-9) bound to the active site of dipeptidyl… | x-ray diffraction | A, B | — | — |
| 2BUB | Crystal Structure Of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor | x-ray diffraction | A, B | — | — |
| 2BUB | Crystal structure of human dipeptidyl peptidase IV (CD26) in complex with a reversed amide inhibitor | x-ray diffraction | A, B | — | — |
| 2FJP | Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor | x-ray diffraction | A, B | — | — |
| 2FJP | Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor | x-ray diffraction | A, B | — | — |
| 2G5P | Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine… | x-ray diffraction | A, B | — | — |
| 2G5P | Crystal structure of human dipeptidyl peptidase IV (dppiv) complexed with cyanopyrrolidine… | x-ray diffraction | A, B | — | — |
| 2G5T | Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine… | x-ray diffraction | A, B | — | — |
| 2G5T | Crystal structure of human dipeptidyl peptidase IV (dppiv) complexed with cyanopyrrolidine… | x-ray diffraction | A, B | — | — |
| 2G63 | Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine… | x-ray diffraction | A, B, C, D | — | — |
| 2G63 | Crystal structure of human dipeptidyl peptidase IV (dppiv) complexed with cyanopyrrolidine… | x-ray diffraction | A, B, C, D | — | — |
| 2I03 | Crystal structure of human dipeptidyl peptidase 4 (DPP IV) with potent alkynyl cyanopyrrolidine… | x-ray diffraction | A, B, C, D | — | — |
| 2I03 | Crystal structure of human dipeptidyl peptidase 4 (dpp IV) with potent alkynyl cyanopyrrolidine… | x-ray diffraction | A, B, C, D | — | — |
| 2I78 | Crystal structure of human dipeptidyl peptidase IV (DPP IV) complexed with ABT-341, a… | x-ray diffraction | A, B, C, D | — | — |
| 2I78 | Crystal structure of human dipeptidyl peptidase IV (dpp IV) complexed with abt-341, a… | x-ray diffraction | A, B, C, D | — | — |
| 2IIT | Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor | x-ray diffraction | A, B | — | — |
| 2IIT | Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor | x-ray diffraction | A, B | — | — |
| 2IIV | Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor | x-ray diffraction | A, B | — | — |
| 2IIV | Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor | x-ray diffraction | A, B | — | — |
| 2JID | Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl)… | x-ray diffraction | A, B | — | — |
| 2JID | Human dipeptidyl peptidase IV in complex with 1-(3,4-dimethoxy-phenyl)… | x-ray diffraction | A, B | — | — |
| 2OAG | Crystal structure of human dipeptidyl peptidase IV (DPPIV) with pyrrolidine-constrained… | x-ray diffraction | A, B, C, D | — | — |
| 2OAG | Crystal structure of human dipeptidyl peptidase IV (dppiv) with pyrrolidine-constrained… | x-ray diffraction | A, B, C, D | — | — |
| 2OGZ | Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor | x-ray diffraction | A, B | — | — |
| 2OGZ | Crystal structure of dpp-IV complexed with lilly aryl ketone inhibitor | x-ray diffraction | A, B | — | — |
| 2OLE | Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Cyclic Hydrazine Derivatives | x-ray diffraction | A, B | — | — |
| 2OLE | Crystal structure of human dipeptidyl peptidase IV (dppiv) complex with cyclic hydrazine derivatives | x-ray diffraction | A, B | — | — |
137 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 14 records
- NA · Sodium ion · in 9 records
- 6RL · 2-[[6-[(3~{R})-3-azanylpiperidin-1-yl]-3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]methyl]-4-fluoranyl-benzenecarboni trile · in 2 records
- 75J · 2-({2-[(3R)-3-aminopiperidin-1-yl]-3-(but-2-yn-1-yl)-4-oxo-3,4-dihydro-5H-imidazo[2,1-b]purin-5-yl}methyl) benzonitrile · in 2 records
- 75L · 2-[(3R)-3-aminopiperidin-1-yl]-3-(but-2-yn-1-yl)-6-[(4-methylquinazolin-2-yl)methyl]-6,7,8,9-tetrahydropyrimido[2,1-b]purin-4(3H)-one · in 2 records
- LF7 · 2-{[(1r,3s,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]amino}-1-{(2S)-2-[(E)-iminomethyl]pyrrolidin-1-yl}ethan-1-o ne · in 2 records
- 6AJ · 2-({2-[(3R)-3-aminopiperidin-1-yl]-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl}methyl)-4-fluorobenzonitrile · in 1 record
- 75M · 4-({2-[(3R)-3-aminopiperidin-1-yl]-3-(but-2-yn-1-yl)-4-oxo-3,4-dihydro-5H-imidazo[2,1-b]purin-5-yl}methyl) benzonitrile · in 1 record
- 75N · 2-[(3R)-3-aminopiperidin-1-yl]-3-(but-2-yn-1-yl)-5-[(4-methylquinazolin-2-yl)methyl]-3H-imidazo[2,1-b]purin-4(5H)-one · in 1 record
- 8O3 · (R)-4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl) piperazin-2-one · in 1 record
- 8OL · (S)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one · in 1 record
- 8VU · (R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazine-2-one · in 1 record
- 9EL · (2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2, 3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile · in 1 record
- C8S · (2S)-2-amino-1-[(1S,3S,5S)-3-(aminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-2-[(1R,3R,5S,7S)-3,5-dihydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-one · in 1 record
- HL1 · (2~{S},3~{R})-8,9-dimethoxy-3-[2,4,5-tris(fluoranyl)phenyl]-2,3-dihydro-1~{H}-benzo[f]chromen-2-amine · in 1 record
Experiment against prediction
- 6B1E chain A against the predicted model P27487: TM-score 1.00, RMSD 0.33 Å
- 6B1E chain A against the predicted model P27487: TM-score 1.00, RMSD 0.33 Å
- 4A5S chain A against the predicted model P27487: TM-score 1.00, RMSD 0.34 Å
- 4A5S chain A against the predicted model P27487: TM-score 1.00, RMSD 0.34 Å
- 4N8D chain A against the predicted model P27487: TM-score 1.00, RMSD 0.34 Å
- 4N8D chain A against the predicted model P27487: TM-score 1.00, RMSD 0.34 Å
- 2QOE chain A against the predicted model P27487: TM-score 1.00, RMSD 0.35 Å
- 2QOE chain A against the predicted model P27487: TM-score 1.00, RMSD 0.35 Å
- 5T4F chain A against the predicted model P27487: TM-score 1.00, RMSD 0.35 Å
- 3HAB chain A against the predicted model P27487: TM-score 1.00, RMSD 0.35 Å
Elsewhere
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