GL1X · GenesisL1 explorer

Ligand · 2VH

2VH · (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine

2VH, (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine (C17 H19 F3 N4 O3 S, 416.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
2VH
Formula
C17 H19 F3 N4 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

2VH in 2 structures; the first of them:

  • 4PNZ · Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor Omarigliptin… · 2VH A802 · binds ARG125, GLU205, GLU206, SER209, PHE357, TYR547, SER630, TYR631 and 7 more
  • 4PNZ · Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor omarigliptin… · 2VH A802 · binds ARG125, GLU205, GLU206, SER209, PHE357, TYR547, SER630, TYR631 and 7 more

Residues it binds most

TYR 4, GLU 4, SER 4, VAL 4, ARG 4, ASN 4, HIS 4, PHE 4, TRP 4 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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