UniProt P26839
Virginiamycin A acetyltransferase (P26839)
Virginiamycin A acetyltransferase (UniProt P26839), EC 2.3.1.-: 10 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 80 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P26839
- Protein
- Virginiamycin A acetyltransferase
- EC
- 2.3.1.-
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 80 · 10 records with a druggable one
Structures
11 records of P26839 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4HUR | Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus… | x-ray diffraction | A, B, C | ACO, SO4, NA, CL | 5 (best 0.75) |
| 4HUR | Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus… | x-ray diffraction | A, B, C | ACO, SO4, NA, CL | 5 (best 0.75) |
| 4HUS | Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus… | x-ray diffraction | A, B, C | SO4, NA, CL, VIR | 5 (best 0.76) |
| 4HUS | Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus… | x-ray diffraction | A, B, C | SO4, NA, CL, VIR | 5 (best 0.76) |
| 4MYO | Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus… | x-ray diffraction | A, B, C | MG, CL, SO4 | 4 (best 0.75) |
| 4MYO | Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus… | x-ray diffraction | A, B, C | MG, CL, SO4 | 4 (best 0.75) |
| 6X3C | Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex… | x-ray diffraction | A, B, C, D, E, F | SXA, O7S, PO4, SO4, CL, MG | 13 (best 0.81) |
| 6X3C | Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex… | x-ray diffraction | A, B, C, D, E, F | SXA, O7S, PO4, SO4, CL, MG | 13 (best 0.81) |
| 6X3J | Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex… | x-ray diffraction | A, B, C, D, E, F | O7V, PO4, SXA, CL, MG | 12 (best 0.77) |
| 6X3J | Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex… | x-ray diffraction | A, B, C, D, E, F | O7V, PO4, SXA, CL, MG | 12 (best 0.77) |
| P26839 | AlphaFold monomer V2.0 prediction for virginiamycin a acetyltransferase (P26839) | predicted | A | — | 2 (best 0.44) |
Ligands
- CL · Chloride ion · in 10 records
- SO4 · Sulfate ion · in 8 records
- MG · Magnesium ion · in 6 records
- NA · Sodium ion · in 4 records
- PO4 · Phosphate ion · in 4 records
- SXA · Thioacetic acid S-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester · in 4 records
- ACO · Acetyl coenzyme *A · in 2 records
- O7S · (3r,4r,5e,10e,12e,14s,16r,26ar)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9, 14,15,16,17,24,25,26,26A-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-C][1,8,4, 19]dioxadiazacyclotetracosine-1,7,22-trione · in 2 records
- O7V · (2R)-2-[(3s,4r,5e,10e,12e,14s,16r,26ar)-16-fluoro-14-hydroxy-4,12-dimethyl-1,7,22-trioxo-4,7,8,9,14,15,16, 17,24,25,26,26A-dodecahydro-1H,3H,22H-21,18-(azeno) pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate · in 2 records
- VIR · Virginiamycin M1 · in 2 records
Experiment against prediction
- 6X3J chain A against the predicted model P26839: TM-score 0.99, RMSD 0.49 Å
- 6X3J chain A against the predicted model P26839: TM-score 0.99, RMSD 0.49 Å
- 6X3J chain F against the predicted model P26839: TM-score 0.99, RMSD 0.50 Å
- 6X3J chain F against the predicted model P26839: TM-score 0.99, RMSD 0.50 Å
- 6X3C chain C against the predicted model P26839: TM-score 0.99, RMSD 0.51 Å
- 6X3C chain C against the predicted model P26839: TM-score 0.99, RMSD 0.51 Å
- 4HUS chain C against the predicted model P26839: TM-score 0.99, RMSD 0.54 Å
- 4HUS chain C against the predicted model P26839: TM-score 0.99, RMSD 0.54 Å
- 6X3C chain D against the predicted model P26839: TM-score 0.99, RMSD 0.56 Å
- 6X3C chain D against the predicted model P26839: TM-score 0.99, RMSD 0.56 Å
Elsewhere
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