UniProt P26449
Cell cycle arrest protein (P26449)
Cell cycle arrest protein (UniProt P26449): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 74 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P26449
- Protein
- Cell cycle arrest protein
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 74 · 10 records with a druggable one
Structures
11 records of P26449 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1U4C | Structure of spindle checkpoint protein Bub3 | x-ray diffraction | A, B | — | 5 (best 0.68) |
| 1U4C | Structure of spindle checkpoint protein BUB3 | x-ray diffraction | A, B | — | 5 (best 0.68) |
| 1YFQ | High resolution S. cerevisiae Bub3 mitotic checkpoint protein | x-ray diffraction | A | CA | 4 (best 0.69) |
| 1YFQ | High resolution S. cerevisiae BUB3 mitotic checkpoint protein | x-ray diffraction | A | CA | 4 (best 0.69) |
| 2I3S | Bub3 complex with Bub1 GLEBS motif | x-ray diffraction | A, C, E | — | 7 (best 0.72) |
| 2I3S | BUB3 complex with BUB1 glebs motif | x-ray diffraction | A, C, E | — | 7 (best 0.72) |
| 2I3T | Bub3 complex with Mad3 (BubR1) GLEBS motif | x-ray diffraction | A, C, E, G | — | 13 (best 0.71) |
| 2I3T | BUB3 complex with MAD3 (BUBR1) glebs motif | x-ray diffraction | A, C, E, G | — | 13 (best 0.71) |
| 4BL0 | Crystal structure of yeast Bub3-Bub1 bound to phospho-Spc105 | x-ray diffraction | A, D | MG | 8 (best 0.73) |
| 4BL0 | Crystal structure of yeast BUB3-BUB1 bound to phospho-SPC105 | x-ray diffraction | A, D | MG | 8 (best 0.73) |
| P26449 | AlphaFold monomer V2.0 prediction for cell cycle arrest protein BUB3 (P26449) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4BL0 chain D against the predicted model P26449: TM-score 0.97, RMSD 1.28 Å
- 4BL0 chain D against the predicted model P26449: TM-score 0.97, RMSD 1.28 Å
- 2I3S chain C against the predicted model P26449: TM-score 0.97, RMSD 1.32 Å
- 2I3S chain C against the predicted model P26449: TM-score 0.97, RMSD 1.32 Å
- 4BL0 chain A against the predicted model P26449: TM-score 0.97, RMSD 1.47 Å
- 4BL0 chain A against the predicted model P26449: TM-score 0.97, RMSD 1.47 Å
- 2I3S chain E against the predicted model P26449: TM-score 0.97, RMSD 1.46 Å
- 2I3S chain E against the predicted model P26449: TM-score 0.97, RMSD 1.46 Å
- 2I3T chain C against the predicted model P26449: TM-score 0.96, RMSD 1.57 Å
- 2I3T chain C against the predicted model P26449: TM-score 0.96, RMSD 1.57 Å
Elsewhere
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