UniProt P25694
Cell division control protein 48 (P25694)
Cell division control protein 48 (UniProt P25694), EC 3.6.4.6: 12 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 80 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P25694
- Protein
- Cell division control protein 48
- EC
- 3.6.4.6
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 80 · 4 records with a druggable one
Structures
13 records of P25694 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6OA9 | Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP | electron microscopy | A, B, C, D, E, F | ATP, ADP | — |
| 6OA9 | CDC48-NPL4 complex processing poly-ubiquitinated substrate in the presence of ATP | electron microscopy | A, B, C, D, E, F | ATP, ADP | — |
| 6OAA | CDC48-NPL4 complex processing poly-ubiquitinated substrate in the presence of ADP-befx, state 1 | electron microscopy | B, C, D, E | ADP, BEF | — |
| 6OAB | Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 2 | electron microscopy | D, E, B, C, A | ADP, BEF | — |
| 6OAB | CDC48-NPL4 complex processing poly-ubiquitinated substrate in the presence of ADP-befx, state 2 | electron microscopy | D, E, B, C, A | ADP, BEF | — |
| 6OMB | CDC48 hexamer (subunits a to E) with substrate bound to the central pore | electron microscopy | A, B, C, D, E | ADP, BEF, MG | — |
| 6OPC | CDC48 hexamer in a complex with substrate and SHP1(UBX domain) | electron microscopy | A, B, C, D, E, F | ADP, BEF, MG | — |
| 8DAR | Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex unbound but in the presence of… | electron microscopy | A, B, C, D, E, F | ATP, ADP | 20 (best 0.86) |
| 8DAW | Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to three ubiquitin moieties and one unfolded… | electron microscopy | A, B, C, D, E, F | ATP, ADP | — |
| 8U9Z | Cdc48-Shp1 unfolding native substrate, Class 7 | electron microscopy | A, B, C, D, E, F | 08T, MG, ADP | 20 (best 0.85) |
| 8UA1 | Cdc48-Shp1 unfolding native substrate, Class 9 | electron microscopy | A, B, C, D, E, F | 08T, MG, ADP | 20 (best 0.85) |
| 8UAA | Cdc48-Shp1 unfolding native substrate, Class 3 | electron microscopy | A, B, C, D, E, F | 08T, MG, ADP | 20 (best 0.80) |
| P25694 | AlphaFold monomer V2.0 prediction for cell division control protein 48 (P25694) | predicted | A | — | — |
Ligands
- ADP · Adenosine-5'-diphosphate · in 12 records
- BEF · Beryllium trifluoride ion · in 5 records
- MG · Magnesium ion · in 5 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- 08T · [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-tris(fluoranyl)beryllium · in 3 records
Experiment against prediction
- 6OA9 chain B against the predicted model P25694: TM-score 0.91, RMSD 2.60 Å
- 6OA9 chain B against the predicted model P25694: TM-score 0.91, RMSD 2.60 Å
- 6OA9 chain C against the predicted model P25694: TM-score 0.88, RMSD 3.04 Å
- 6OA9 chain C against the predicted model P25694: TM-score 0.88, RMSD 3.04 Å
- 8DAW chain B against the predicted model P25694: TM-score 0.87, RMSD 4.00 Å
- 8DAW chain A against the predicted model P25694: TM-score 0.85, RMSD 4.16 Å
- 6OA9 chain D against the predicted model P25694: TM-score 0.85, RMSD 3.59 Å
- 6OA9 chain D against the predicted model P25694: TM-score 0.85, RMSD 3.59 Å
- 8DAW chain D against the predicted model P25694: TM-score 0.83, RMSD 3.98 Å
- 8DAW chain C against the predicted model P25694: TM-score 0.83, RMSD 4.04 Å
Elsewhere
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