UniProt P25582
27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase (P25582)
27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase (UniProt P25582), EC 2.1.1.167: 10 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P25582
- Protein
- 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase
- EC
- 2.1.1.167
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 10 · 4 records with a druggable one
Structures
11 records of P25582 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6ELZ | State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | electron microscopy | w | — | 1 (best 0.88) |
| 6EM5 | State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | w | — | — |
| 6EM5 | State D architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | w | — | — |
| 6YLX | pre-60S State NE1 (TAP-Flag-Nop53) | electron microscopy | w | — | 2 (best 0.87) |
| 7NAC | State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model | electron microscopy | w | — | — |
| 7NAF | State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model | electron microscopy | w | — | — |
| 7OHR | Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae | electron microscopy | w | — | 2 (best 0.87) |
| 7R72 | State E1 nucleolar 60S ribosome biogenesis intermediate - Spb4 local model | electron microscopy | w | — | — |
| 7R7A | State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model | electron microscopy | w | — | — |
| 7R7C | State E2 nucleolar 60S ribosomal biogenesis intermediate - L1 stalk local model | electron microscopy | w | — | 1 (best 0.47) |
| P25582 | AlphaFold monomer V2.0 prediction for 27S pre-rRNA (GUANOSINE(2922)-2'-O)-methyltransferase (P25582) | predicted | A | — | 4 (best 0.51) |
Experiment against prediction
- 7R7C chain w against the predicted model P25582: TM-score 0.82, RMSD 0.24 Å
- 7NAF chain w against the predicted model P25582: TM-score 0.70, RMSD 4.28 Å
- 6YLX chain w against the predicted model P25582: TM-score 0.61, RMSD 4.49 Å
- 6EM5 chain w against the predicted model P25582: TM-score 0.54, RMSD 3.96 Å
- 6EM5 chain w against the predicted model P25582: TM-score 0.54, RMSD 3.96 Å
- 6ELZ chain w against the predicted model P25582: TM-score 0.54, RMSD 3.96 Å
- 7NAC chain w against the predicted model P25582: TM-score 0.41, RMSD 4.88 Å
- 7OHR chain w against the predicted model P25582: TM-score 0.36, RMSD 3.76 Å
- 7R7A chain w against the predicted model P25582: TM-score 0.26, RMSD 4.86 Å
- 7R72 chain w against the predicted model P25582: TM-score 0.24, RMSD 4.17 Å
Elsewhere
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