UniProt P24482
DNA polymerase epsilon subunit B (P24482)
DNA polymerase epsilon subunit B (UniProt P24482), EC 2.7.7.7: 14 experimental structures and 1 predicted model on GenesisL1, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P24482
- Protein
- DNA polymerase epsilon subunit B
- EC
- 2.7.7.7
- Experimental structures
- 14
- Predicted models
- 1
- Pockets
- 45 · 11 records with a druggable one
Structures
15 records of P24482 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6HV8 | Cryo-EM structure of S. cerevisiae Polymerase epsilon deltacat mutant | electron microscopy | B | — | 7 (best 0.78) |
| 6HV8 | Cryo-EM structure of S. cerevisiae polymerase epsilon deltacat mutant | electron microscopy | B | — | — |
| 6HV9 | S. cerevisiae cmg-pol epsilon-DNA | electron microscopy | B | — | — |
| 6WJV | Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme | electron microscopy | 2 | — | 9 (best 0.88) |
| 6WJV | Structure of the saccharomyces cerevisiae polymerase epsilon holoenzyme | electron microscopy | 2 | — | — |
| 7PMK | S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I) | electron microscopy | R | — | 2 (best 0.80) |
| 7PMN | S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) | electron microscopy | R | — | 3 (best 0.80) |
| 7QHS | S. cerevisiae CMGE nucleating origin DNA melting | electron microscopy | F | — | 5 (best 0.86) |
| 7Z13 | S. cerevisiae CMGE dimer nucleating origin DNA melting | electron microscopy | F, M | — | 5 (best 0.86) |
| 8KG6 | Yeast replisome in state I | electron microscopy | N | — | 3 (best 0.84) |
| 8KG9 | Yeast replisome in state III | electron microscopy | N | — | 3 (best 0.87) |
| 8P62 | S. cerevisiae ssDNA-sCMGE after DNA replication initiation | electron microscopy | F | — | 4 (best 0.88) |
| 8P63 | S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation | electron microscopy | F | — | 3 (best 0.89) |
| 8W7M | Yeast replisome in state V | electron microscopy | N | — | 1 (best 0.79) |
| P24482 | AlphaFold monomer V2.0 prediction for DNA polymerase epsilon subunit B (P24482) | predicted | A | — | — |
Experiment against prediction
- 6HV8 chain B against the predicted model P24482: TM-score 0.95, RMSD 1.74 Å
- 6HV8 chain B against the predicted model P24482: TM-score 0.95, RMSD 1.74 Å
- 6WJV chain 2 against the predicted model P24482: TM-score 0.94, RMSD 1.95 Å
- 6WJV chain 2 against the predicted model P24482: TM-score 0.94, RMSD 1.95 Å
- 8W7M chain N against the predicted model P24482: TM-score 0.87, RMSD 1.37 Å
- 6HV9 chain B against the predicted model P24482: TM-score 0.86, RMSD 1.98 Å
- 7PMK chain R against the predicted model P24482: TM-score 0.85, RMSD 2.37 Å
- 7PMN chain R against the predicted model P24482: TM-score 0.85, RMSD 2.23 Å
- 8P63 chain F against the predicted model P24482: TM-score 0.84, RMSD 2.41 Å
- 8P62 chain F against the predicted model P24482: TM-score 0.84, RMSD 2.33 Å
Elsewhere
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