UniProt P23979
5-hydroxytryptamine receptor 3A (P23979)
5-hydroxytryptamine receptor 3A (UniProt P23979): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P23979
- Protein
- 5-hydroxytryptamine receptor 3A
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 40 · 2 records with a druggable one
Structures
10 records of P23979 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4PIR | X-ray structure of the mouse serotonin 5-HT3 receptor | x-ray diffraction | A, B, C, D, E | — | — |
| 4PIR | X-ray structure of the mouse serotonin 5-HT3 receptor | x-ray diffraction | A, B, C, D, E | — | — |
| 6HIO | Mouse serotonin 5-HT3 receptor, serotonin-bound, I1 conformation | electron microscopy | A, E, B, C, D | NAG, SRO | — |
| 6HIS | Mouse serotonin 5-HT3 receptor, tropisetron-bound, T conformation | electron microscopy | A, E, B, C, D | NAG, TKT | 20 (best 0.88) |
| 6HIS | Mouse serotonin 5-HT3 receptor, tropisetron-bound, T conformation | electron microscopy | A, E, B, C, D | NAG, TKT | — |
| 6Y59 | 5-HT3A receptor in salipro (apo, C5 symmetric) | electron microscopy | A, B, C, D, E | — | — |
| 6Y5A | Serotonin-bound 5-HT3A receptor in salipro | electron microscopy | A, C, D, B, E | SRO | — |
| 6Y5B | 5-HT3A receptor in salipro (apo, asymmetric) | electron microscopy | A, B, C, D, E | — | — |
| 8C1Z | Tetrameric 5-HT3aR in Salipro (apo state, symmetric) | electron microscopy | A, B, C, D | — | 20 (best 0.78) |
| P23979 | AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 3A (P23979) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4PIR chain A against the predicted model P23979: TM-score 0.97, RMSD 1.29 Å
- 4PIR chain A against the predicted model P23979: TM-score 0.97, RMSD 1.29 Å
- 4PIR chain C against the predicted model P23979: TM-score 0.97, RMSD 1.31 Å
- 4PIR chain C against the predicted model P23979: TM-score 0.97, RMSD 1.31 Å
- 4PIR chain D against the predicted model P23979: TM-score 0.97, RMSD 1.33 Å
- 4PIR chain D against the predicted model P23979: TM-score 0.97, RMSD 1.33 Å
- 4PIR chain E against the predicted model P23979: TM-score 0.97, RMSD 1.34 Å
- 4PIR chain E against the predicted model P23979: TM-score 0.97, RMSD 1.34 Å
- 6HIS chain C against the predicted model P23979: TM-score 0.97, RMSD 1.30 Å
- 6HIS chain C against the predicted model P23979: TM-score 0.97, RMSD 1.30 Å
Elsewhere
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