UniProt P23921
Ribonucleoside-diphosphate reductase large subunit (P23921)
Ribonucleoside-diphosphate reductase large subunit (UniProt P23921), EC 1.17.4.1: 24 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 220 pockets. Binding sites, druggability and experiment against…
- UniProt
- P23921
- Protein
- Ribonucleoside-diphosphate reductase large subunit
- EC
- 1.17.4.1
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 220 · 20 records with a druggable one
Structures
25 records of P23921 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WGH | Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg. | x-ray diffraction | A, B | MG, DTP | 10 (best 0.79) |
| 2WGH | Human ribonucleotide reductase R1 subunit (RRM1) in complex with datp and mg. | x-ray diffraction | A, B | MG, DTP | 10 (best 0.79) |
| 3HNC | Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP | x-ray diffraction | A, B | MG, TTP, SO4 | 10 (best 0.75) |
| 3HNC | Crystal structure of human ribonucleotide reductase 1 bound to the effector ttp | x-ray diffraction | A, B | MG, TTP, SO4 | 10 (best 0.75) |
| 3HND | Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP and substrate GDP | x-ray diffraction | A, B | MG, TTP, GDP, SO4 | 12 (best 0.74) |
| 3HND | Crystal structure of human ribonucleotide reductase 1 bound to the effector ttp and substrate GDP | x-ray diffraction | A, B | MG, TTP, GDP, SO4 | 12 (best 0.74) |
| 3HNE | Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP | x-ray diffraction | A, B | TTP, MG, SO4, ATP | 14 (best 0.71) |
| 3HNE | Crystal structure of human ribonucleotide reductase 1 bound to the effectors ttp and ATP | x-ray diffraction | A, B | TTP, MG, SO4, ATP | 14 (best 0.71) |
| 3HNF | Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP | x-ray diffraction | A, B | MG, TTP, SO4, DTP | 10 (best 0.74) |
| 3HNF | Crystal structure of human ribonucleotide reductase 1 bound to the effectors ttp and datp | x-ray diffraction | A, B | MG, TTP, SO4, DTP | 10 (best 0.74) |
| 4X3V | Crystal structure of human ribonucleotide reductase 1 bound to inhibitor | x-ray diffraction | A, B | TTP, 3X4 | 9 (best 0.76) |
| 4X3V | Crystal structure of human ribonucleotide reductase 1 bound to inhibitor | x-ray diffraction | A, B | TTP, 3X4 | 9 (best 0.76) |
| 5D1Y | Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with… | x-ray diffraction | A, B | — | 7 (best 0.76) |
| 5D1Y | Low resolution crystal structure of human ribonucleotide reductase ALPHA6 hexamer in complex with… | x-ray diffraction | A, B | — | 7 (best 0.76) |
| 5TUS | Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small… | x-ray diffraction | A, B | TTP, MG, 7LL | 12 (best 0.76) |
| 5TUS | Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small… | x-ray diffraction | A, B | TTP, MG, 7LL | — |
| 6AUI | Human ribonucleotide reductase large subunit (alpha) with dATP and CDP | electron microscopy | A, B, C, D, E, F | DTP, MG, CDP | 20 (best 0.75) |
| 6AUI | Human ribonucleotide reductase large subunit (alpha) with datp and cdp | electron microscopy | A, B, C, D, E, F | DTP, CDP, MG | — |
| 6L3R | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with… | x-ray diffraction | A, E | TTP, MG, E4X, SO4 | 14 (best 0.67) |
| 6L3R | Crystal structure of ribonucleotide reductase R1 subunit, RRM1 in complex with… | x-ray diffraction | A, E | TTP, E4X, SO4 | — |
| 6L7L | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with… | x-ray diffraction | A, E | MG, TTP, E6O | 9 (best 0.73) |
| 6L7L | Crystal structure of ribonucleotide reductase R1 subunit, RRM1 in complex with… | x-ray diffraction | A, E | MG, TTP, E6O | — |
| 6LKM | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with… | x-ray diffraction | A, B | MG, TTP, EJ6 | 14 (best 0.73) |
| 6LKM | Crystal structure of ribonucleotide reductase R1 subunit, RRM1 in complex with… | x-ray diffraction | A, B | MG, TTP, EJ6 | — |
| P23921 | AlphaFold monomer V2.0 prediction for ribonucleoside-diphosphate reductase large subunit (P23921) | predicted | A | — | 7 (best 0.76) |
Ligands
- MG · Magnesium ion · in 19 records
- TTP · Thymidine-5'-triphosphate · in 18 records
- SO4 · Sulfate ion · in 10 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 6 records
- 3X4 · N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine · in 2 records
- 7LL · 2-hydroxy-N'-[(Z)-(2-hydroxynaphthalen-1-yl) methylidene]benzohydrazide · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- CDP · Cytidine-5'-diphosphate · in 2 records
- E4X · 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide · in 2 records
- E6O · 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl) sulfamoyl)benzamide · in 2 records
- EJ6 · 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide · in 2 records
- GDP · Guanosine-5'-diphosphate · in 2 records
Experiment against prediction
- 6L7L chain E against the predicted model P23921: TM-score 1.00, RMSD 0.44 Å
- 6L7L chain E against the predicted model P23921: TM-score 1.00, RMSD 0.44 Å
- 6L7L chain A against the predicted model P23921: TM-score 1.00, RMSD 0.48 Å
- 6L7L chain A against the predicted model P23921: TM-score 1.00, RMSD 0.48 Å
- 6L3R chain A against the predicted model P23921: TM-score 1.00, RMSD 0.58 Å
- 6L3R chain A against the predicted model P23921: TM-score 1.00, RMSD 0.58 Å
- 6L3R chain E against the predicted model P23921: TM-score 1.00, RMSD 0.60 Å
- 6L3R chain E against the predicted model P23921: TM-score 1.00, RMSD 0.60 Å
- 2WGH chain A against the predicted model P23921: TM-score 0.99, RMSD 0.69 Å
- 2WGH chain A against the predicted model P23921: TM-score 0.99, RMSD 0.69 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.