UniProt P23895
Multidrug transporter EmrE (P23895)
Multidrug transporter EmrE (UniProt P23895): 17 experimental structures and 3 predicted models on GenesisL1, 6 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P23895
- Protein
- Multidrug transporter EmrE
- Experimental structures
- 17
- Predicted models
- 3
- Ligands
- 6
- Pockets
- 11 · 4 records with a druggable one
Structures
20 records of P23895 in the MolNFT archive: 17 experimental, 3 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3B5D | EmrE multidrug transporter in complex with TPP, C2 crystal form | x-ray diffraction | A, B | — | — |
| 3B5D | Emre multidrug transporter in complex with tpp, C2 crystal form | x-ray diffraction | A, B | — | — |
| 3B61 | EmrE multidrug transporter, apo crystal form | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3B61 | Emre multidrug transporter, apo crystal form | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3B62 | EmrE multidrug transporter in complex with P4P, P21 crystal form | x-ray diffraction | A, B, C, D | — | — |
| 3B62 | Emre multidrug transporter in complex with P4P, P21 crystal form | x-ray diffraction | A, B, C, D | — | — |
| 7MGX | Structure of emre-D3 mutant in complex with monobody L10 and methyl viologen | x-ray diffraction | A, E, B, F | KHJ | — |
| 7MH6 | Structure of EmrE-D3 mutant in complex with monobody L10 in low pH (protonated state) | x-ray diffraction | B, A | — | 3 (best 0.77) |
| 7MH6 | Structure of emre-D3 mutant in complex with monobody L10 in low pH (protonated state) | x-ray diffraction | B, A | — | — |
| 7SFQ | EmrE S64V Mutant Bound to tetra(4-fluorophenyl)phosphonium at pH 8.0 | solid-state nmr | A, B | VCJ | 3 (best 0.81) |
| 7SFQ | Emre S64V mutant bound to TETRA(4-FLUOROPHENYL)PHOSPHONIUM at pH 8.0 | solid-state nmr | A, B | VCJ | — |
| 7SSU | Structure of EmrE-D3 mutant in complex with monobody L10 and methyltriphenylphosphonium | x-ray diffraction | A, B | B5J | 2 (best 0.81) |
| 7SSU | Structure of emre-D3 mutant in complex with monobody L10 and methyltriphenylphosphonium | x-ray diffraction | A, B | B5J | — |
| 7SV9 | Structure of emre-D3 mutant in complex with monobody L10 and tpp | x-ray diffraction | B, A | P4P | — |
| 7SVX | Structure of emre-D3 mutant in complex with monobody L10 and harmane | x-ray diffraction | A, B | CN9 | — |
| 7T00 | Structure of EmrE-D3 mutant in complex with monobody L10 and benzyltrimethylammonium | x-ray diffraction | A, B | E00 | 3 (best 0.77) |
| 7T00 | Structure of emre-D3 mutant in complex with monobody L10 and benzyltrimethylammonium | x-ray diffraction | A, B | E00 | — |
| 2I68 | Cryo-EM based theoretical model structure of transmembrane domain of the multidrug-resistance… | electron crystallography | A, B | — | — |
| 2I68 | Cryo-EM based theoretical model structure of transmembrane domain of the multidrug-resistance… | electron crystallography | A, B | — | — |
| P23895 | AlphaFold monomer V2.0 prediction for multidrug transporter emre (P23895) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7MH6 chain A against the predicted model P23895: TM-score 0.86, RMSD 1.90 Å
- 7MH6 chain A against the predicted model P23895: TM-score 0.86, RMSD 1.90 Å
- 7SV9 chain A against the predicted model P23895: TM-score 0.86, RMSD 1.96 Å
- 7MGX chain E against the predicted model P23895: TM-score 0.85, RMSD 2.01 Å
- 7SSU chain A against the predicted model P23895: TM-score 0.85, RMSD 2.07 Å
- 7SSU chain A against the predicted model P23895: TM-score 0.85, RMSD 2.07 Å
- 7MGX chain A against the predicted model P23895: TM-score 0.84, RMSD 2.10 Å
- 7SVX chain A against the predicted model P23895: TM-score 0.83, RMSD 2.21 Å
- 7T00 chain A against the predicted model P23895: TM-score 0.82, RMSD 2.23 Å
- 7T00 chain A against the predicted model P23895: TM-score 0.82, RMSD 2.23 Å
Elsewhere
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