UniProt P23827
Ecotin (P23827)
Ecotin (UniProt P23827): 41 experimental structures and 1 predicted model on GenesisL1, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P23827
- Protein
- Ecotin
- Experimental structures
- 41
- Predicted models
- 1
- Pockets
- 14 · 2 records with a druggable one
Structures
42 records of P23827 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AZZ | Fiddler crab collagenase complexed to ecotin | x-ray diffraction | C, D | — | — |
| 1AZZ | Fiddler crab collagenase complexed to ecotin | x-ray diffraction | C, D | — | — |
| 1ECY | Protease inhibitor ecotin | x-ray diffraction | A | — | — |
| 1ECY | Protease inhibitor ecotin | x-ray diffraction | A | — | — |
| 1ECZ | Protease inhibitor ecotin | x-ray diffraction | A, B | — | — |
| 1ECZ | Protease inhibitor ecotin | x-ray diffraction | A, B | — | — |
| 1EZS | Crystal structure of ecotin mutant M84R, W67A, G68A, Y69A, D70A bound to rat anionic trypsin II | x-ray diffraction | A, B | — | — |
| 1EZS | Crystal structure of ecotin mutant M84R, W67A, G68A, Y69A, D70A bound to rat anionic trypsin II | x-ray diffraction | A, B | — | — |
| 1EZU | Ecotin Y69F, D70P bound to D102N trypsin | x-ray diffraction | A, B | — | — |
| 1EZU | Ecotin Y69F, D70P bound to D102N trypsin | x-ray diffraction | A, B | — | — |
| 1FI8 | Rat granzyme B [N66Q] complexed to ecotin [81-84 iepd] | x-ray diffraction | C, D, E, F | — | — |
| 1FI8 | Rat granzyme B [N66Q] complexed to ecotin [81-84 iepd] | x-ray diffraction | C, D, E, F | — | — |
| 1ID5 | Crystal structure of bovine thrombin complex with protease inhibitor ecotin | x-ray diffraction | I | — | — |
| 1ID5 | Crystal structure of bovine thrombin complex with protease inhibitor ecotin | x-ray diffraction | I | — | — |
| 1IFG | Crystal structure of a monomeric form of general protease inhibitor, ecotin in absence of a protease | x-ray diffraction | A | — | — |
| 1IFG | Crystal structure of a monomeric form of general protease inhibitor, ecotin in absence of a protease | x-ray diffraction | A | — | — |
| 1N8O | Crystal structure of a complex between bovine chymotrypsin and ecotin | x-ray diffraction | E | — | — |
| 1N8O | Crystal structure of a complex between bovine chymotrypsin and ecotin | x-ray diffraction | E | — | — |
| 1P0S | Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R | x-ray diffraction | E | — | — |
| 1P0S | Crystal structure of blood coagulation factor xa in complex with ecotin M84R | x-ray diffraction | E | — | — |
| 1SLU | Rat anionic N143H, E151H trypsin complexed to A86H ecotin | x-ray diffraction | A | — | — |
| 1SLU | Rat anionic N143H, E151H trypsin complexed to A86H ecotin | x-ray diffraction | A | — | — |
| 1SLV | Rat anionic N143H, E151H trypsin complexed to A86H ecotin; copper-bound | x-ray diffraction | A | — | — |
| 1SLV | Rat anionic N143H, E151H trypsin complexed to A86H ecotin; copper- bound | x-ray diffraction | A | — | — |
| 1SLW | Rat anionic N143H, E151H trypsin complexed to A86H ecotin; nickel-bound | x-ray diffraction | A | — | — |
| 1SLW | Rat anionic N143H, E151H trypsin complexed to A86H ecotin; nickel- bound | x-ray diffraction | A | — | — |
| 1SLX | Rat anionic N143H, E151H trypsin complexed to A86H ecotin; zinc-bound | x-ray diffraction | A | — | — |
| 1SLX | Rat anionic N143H, E151H trypsin complexed to A86H ecotin; zinc-bound | x-ray diffraction | A | — | — |
| 1XX9 | Crystal Structure of the FXIa Catalytic Domain in Complex with EcotinM84R | x-ray diffraction | C, D | — | — |
| 1XX9 | Crystal structure of the fxia catalytic domain in complex with ECOTINM84R | x-ray diffraction | C, D | — | — |
| 1XXD | Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin | x-ray diffraction | C, D | — | — |
| 1XXD | Crystal structure of the fxia catalytic domain in complex with mutated ecotin | x-ray diffraction | C, D | — | — |
| 1XXF | Crystal Structure of the FXIa Catalytic Domain in Complex with Ecotin Mutant (EcotinP) | x-ray diffraction | C, D | — | — |
| 1XXF | Crystal structure of the fxia catalytic domain in complex with ecotin mutant (ecotinp) | x-ray diffraction | C, D | — | — |
| 4IW4 | Crystal structure of the serine protease domain of MASP-3 in complex with ecotin | x-ray diffraction | C, D | — | — |
| 4IW4 | Crystal structure of the serine protease domain of masp-3 in complex with ecotin | x-ray diffraction | C, D | — | — |
| 4NIY | Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin… | x-ray diffraction | E, F, G, H | — | — |
| 4NIY | Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to yrh-ecotin… | x-ray diffraction | E, F, G, H | — | — |
| 7CBK | Structure of human neutrophil elastase ecotin complex | x-ray diffraction | A, C | — | — |
| 7PQN | Catalytic fragment of MASP-2 in complex with ecotin | x-ray diffraction | C, D | — | 3 (best 0.75) |
| 7PQO | Catalytic fragment of MASP-1 in complex with P1 site mutant ecotin | x-ray diffraction | K, I, J | — | 11 (best 0.85) |
| P23827 | AlphaFold monomer V2.0 prediction for ecotin (P23827) | predicted | A | — | — |
Experiment against prediction
- 4NIY chain H against the predicted model P23827: TM-score 0.98, RMSD 0.62 Å
- 4NIY chain H against the predicted model P23827: TM-score 0.98, RMSD 0.62 Å
- 4NIY chain G against the predicted model P23827: TM-score 0.98, RMSD 0.62 Å
- 4NIY chain G against the predicted model P23827: TM-score 0.98, RMSD 0.62 Å
- 4NIY chain F against the predicted model P23827: TM-score 0.98, RMSD 0.65 Å
- 4NIY chain F against the predicted model P23827: TM-score 0.98, RMSD 0.65 Å
- 4NIY chain E against the predicted model P23827: TM-score 0.98, RMSD 0.67 Å
- 4NIY chain E against the predicted model P23827: TM-score 0.98, RMSD 0.67 Å
- 1XXF chain D against the predicted model P23827: TM-score 0.98, RMSD 0.68 Å
- 1XXF chain D against the predicted model P23827: TM-score 0.98, RMSD 0.68 Å
Elsewhere
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