UniProt P23528
Cofilin-1 (P23528)
Cofilin-1 (UniProt P23528): 16 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P23528
- Protein
- Cofilin-1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 30 · 3 records with a druggable one
Structures
17 records of P23528 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Q8G | NMR structure of human Cofilin | solution nmr | A | — | — |
| 1Q8G | NMR structure of human cofilin | solution nmr | A | — | — |
| 1Q8X | NMR structure of human cofilin | solution nmr | A | — | — |
| 1Q8X | NMR structure of human cofilin | solution nmr | A | — | — |
| 4BEX | Structure of human Cofilin1 | x-ray diffraction | 1 | — | — |
| 4BEX | Structure of human COFILIN1 | x-ray diffraction | 1 | — | — |
| 5HVK | Crystal structure of LIMK1 mutant D460N in complex with full-length cofilin-1 | x-ray diffraction | B, D | ANP | 10 (best 0.79) |
| 5HVK | Crystal structure of LIMK1 mutant D460N in complex with full-length cofilin-1 | x-ray diffraction | B, D | — | — |
| 5L6W | Structure Of the LIMK1-ATPgammaS-CFL1 Complex | x-ray diffraction | C | AGS | — |
| 5L6W | Structure of the LIMK1-atpgammas-CFL1 complex | x-ray diffraction | C | AGS | — |
| 6UBY | Isolated cofilin bound to an actin filament | electron microscopy | I | — | — |
| 6UC0 | Isolated S3D-cofilin bound to an actin filament | electron microscopy | I | — | — |
| 6UC4 | Barbed end side of a cofilactin cluster | electron microscopy | I, M, N, O, P | — | 8 (best 0.85) |
| 6UC4 | Barbed end side of a cofilactin cluster | electron microscopy | I, M, N, O, P | — | — |
| 6VAO | Human cofilin-1 decorated actin filament | electron microscopy | J, F, G, H, I | — | 12 (best 0.84) |
| 6VAO | Human cofilin-1 decorated actin filament | electron microscopy | J, F, G, H, I | — | — |
| P23528 | AlphaFold monomer V2.0 prediction for cofilin-1 (P23528) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4BEX chain 1 against the predicted model P23528: TM-score 0.97, RMSD 0.89 Å
- 4BEX chain 1 against the predicted model P23528: TM-score 0.97, RMSD 0.89 Å
- 5L6W chain C against the predicted model P23528: TM-score 0.96, RMSD 1.25 Å
- 5L6W chain C against the predicted model P23528: TM-score 0.96, RMSD 1.25 Å
- 5HVK chain B against the predicted model P23528: TM-score 0.96, RMSD 1.32 Å
- 5HVK chain B against the predicted model P23528: TM-score 0.96, RMSD 1.32 Å
- 5HVK chain D against the predicted model P23528: TM-score 0.96, RMSD 1.30 Å
- 5HVK chain D against the predicted model P23528: TM-score 0.96, RMSD 1.30 Å
- 6UC0 chain I against the predicted model P23528: TM-score 0.95, RMSD 1.15 Å
- 6UC4 chain P against the predicted model P23528: TM-score 0.95, RMSD 1.15 Å
Elsewhere
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