UniProt P22830
P22830
P22830 (UniProt P22830): 46 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22830
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 3
Structures
47 records of P22830 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HRK | Crystal structure of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 1HRK | Crystal structure of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 2HRC | 1.7 angstrom structure of human ferrochelatase variant R115L | x-ray diffraction | A, B | — | — |
| 2HRC | 1.7 ångström structure of human ferrochelatase variant R115L | x-ray diffraction | A, B | — | — |
| 2HRE | Structure of human ferrochelatase variant E343K with protoporphyrin IX bound | x-ray diffraction | A, B, C, D | — | — |
| 2HRE | Structure of human ferrochelatase variant E343K with protoporphyrin IX bound | x-ray diffraction | A, B, C, D | — | — |
| 2PNJ | Crystal structure of human ferrochelatase mutant with Phe 337 replaced by Ala | x-ray diffraction | A, B | — | — |
| 2PNJ | Crystal structure of human ferrochelatase mutant with phe 337 replaced by ala | x-ray diffraction | A, B | — | — |
| 2PO5 | Crystal structure of human ferrochelatase mutant with His 263 replaced by Cys | x-ray diffraction | A, B | — | — |
| 2PO5 | Crystal structure of human ferrochelatase mutant with his 263 replaced by cys | x-ray diffraction | A, B | — | — |
| 2PO7 | Crystal structure of human ferrochelatase mutant with His 341 replaced by Cys | x-ray diffraction | A, B | — | — |
| 2PO7 | Crystal structure of human ferrochelatase mutant with his 341 replaced by cys | x-ray diffraction | A, B | — | — |
| 2QD1 | 2.2 Angstrom Structure of the human ferrochelatase variant E343K with substrate bound | x-ray diffraction | A, B, C, D | — | — |
| 2QD1 | 2.2 ångström structure of the human ferrochelatase variant E343K with substrate bound | x-ray diffraction | A, B, C, D | — | — |
| 2QD3 | Wild type human ferrochelatase crystallized with ammonium sulfate | x-ray diffraction | A, B | — | — |
| 2QD3 | Wild type human ferrochelatase crystallized with ammonium sulfate | x-ray diffraction | A, B | — | — |
| 2QD4 | Wild type human ferrochelatase crystallized with MnCl2 | x-ray diffraction | A, B | — | — |
| 2QD4 | Wild type human ferrochelatase crystallized with MNCL2 | x-ray diffraction | A, B | — | — |
| 2QD5 | Structure of wild type human ferrochelatase in complex with a lead-porphyrin compound | x-ray diffraction | A, B | — | — |
| 2QD5 | Structure of wild type human ferrochelatase in complex with a lead- porphyrin compound | x-ray diffraction | A, B | — | — |
| 3AQI | H240A variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 3AQI | H240A variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 3HCN | Hg and protoporphyrin bound Human Ferrochelatase | x-ray diffraction | A, B | — | — |
| 3HCN | Hg and protoporphyrin bound human ferrochelatase | x-ray diffraction | A, B | — | — |
| 3HCO | Human ferrochelatase with Cd and protoporphyrin IX bound | x-ray diffraction | A, B | — | — |
| 3HCO | Human ferrochelatase with CD and protoporphyrin IX bound | x-ray diffraction | A, B | — | — |
| 3HCP | Human ferrochelatase with Mn and deuteroporphyrin bound | x-ray diffraction | A, B | — | — |
| 3HCP | Human ferrochelatase with mn and deuteroporphyrin bound | x-ray diffraction | A, B | — | — |
| 3HCR | Human Ferrochelatase with deuteroporphyrin and Ni Bound | x-ray diffraction | A, B | — | — |
| 3HCR | Human ferrochelatase with deuteroporphyrin and ni bound | x-ray diffraction | A, B | — | — |
| 3W1W | Protein-drug complex | x-ray diffraction | A, B | — | — |
| 3W1W | Protein-drug complex | x-ray diffraction | A, B | — | — |
| 4F4D | F337R variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4F4D | F337R variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4KLA | E343D variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4KLA | E343D variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4KLC | E343D/F110A Double mutant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4KLC | E343D/F110A double mutant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4KLR | E343Q variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4KLR | E343Q variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4KMM | M76H variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4KMM | M76H variant of human ferrochelatase | x-ray diffraction | A, B | — | — |
| 4MK4 | S197C variant of human ferrochelatase. | x-ray diffraction | A, B | — | — |
| 4MK4 | S197C variant of human ferrochelatase. | x-ray diffraction | A, B | — | — |
| 7CT7 | Fech - inhibitor complex 2 | x-ray diffraction | A, B | FES, GF9 | — |
| 7CTC | Fech - inhibitor complex 1 | x-ray diffraction | A, D | FES, GFO | — |
| P22830 | AlphaFold monomer V2.0 prediction for ferrochelatase, mitochondrial (P22830) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7CT7 chain A against the predicted model P22830: TM-score 1.00, RMSD 0.47 Å
- 7CTC chain D against the predicted model P22830: TM-score 1.00, RMSD 0.47 Å
- 7CTC chain A against the predicted model P22830: TM-score 1.00, RMSD 0.48 Å
- 7CT7 chain B against the predicted model P22830: TM-score 1.00, RMSD 0.49 Å
- 2PO5 chain A against the predicted model P22830: TM-score 0.99, RMSD 0.55 Å
- 2PO5 chain A against the predicted model P22830: TM-score 0.99, RMSD 0.55 Å
- 3HCP chain A against the predicted model P22830: TM-score 0.99, RMSD 0.55 Å
- 3HCP chain A against the predicted model P22830: TM-score 0.99, RMSD 0.55 Å
- 3W1W chain A against the predicted model P22830: TM-score 0.99, RMSD 0.56 Å
- 3W1W chain A against the predicted model P22830: TM-score 0.99, RMSD 0.56 Å
Elsewhere
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