UniProt P22748
Carbonic anhydrase 4 (P22748)
Carbonic anhydrase 4 (UniProt P22748), EC 4.2.1.1: 20 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22748
- Protein
- Carbonic anhydrase 4
- EC
- 4.2.1.1
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 34 · 2 records with a druggable one
Structures
21 records of P22748 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZNC | Human carbonic anhydrase IV | x-ray diffraction | A, B | — | — |
| 1ZNC | Human carbonic anhydrase IV | x-ray diffraction | A, B | — | — |
| 3F7B | Crystal Structure of soluble domain of CA4 in complex with small molecule. | x-ray diffraction | A, B | — | — |
| 3F7B | Crystal structure of soluble domain of CA4 in complex with small molecule. | x-ray diffraction | A, B | — | — |
| 3F7U | Crystal Structure of soluble domain of CA4 in complex with small molecule. | x-ray diffraction | A, B, C, D | — | — |
| 3F7U | Crystal structure of soluble domain of CA4 in complex with small molecule. | x-ray diffraction | A, B, C, D | — | — |
| 3FW3 | Crystal Structure of soluble domain of CA4 in complex with Dorzolamide | x-ray diffraction | A, B | — | — |
| 3FW3 | Crystal structure of soluble domain of CA4 in complex with dorzolamide | x-ray diffraction | A, B | — | — |
| 5IPZ | Crystal structure of human carbonic anhydrase isozyme IV with… | x-ray diffraction | A, B, C, D | ZN, 6CC | 14 (best 0.74) |
| 5IPZ | Crystal structure of human carbonic anhydrase isozyme IV with 5-(2… | x-ray diffraction | A, B, C, D | — | — |
| 5JN8 | Crystal Structure for the complex of human carbonic anhydrase IV and acetazolamide | x-ray diffraction | A, B, C, D | AZM, ZN, SO4 | — |
| 5JN8 | Crystal structure for the complex of human carbonic anhydrase IV and acetazolamide | x-ray diffraction | A, B, C, D | — | — |
| 5JN9 | Crystal structure for the complex of human carbonic anhydrase IV and ethoxyzolamide | x-ray diffraction | A, B, C, D | ZN, EZL, SO4 | 20 (best 0.74) |
| 5JN9 | Crystal structure for the complex of human carbonic anhydrase IV and ethoxyzolamide | x-ray diffraction | A, B, C, D | — | — |
| 5JNA | Crystal structure for the complex of human carbonic anhydrase IV and topiramate | x-ray diffraction | A, B, C, D | ZN, TOR, SO4 | — |
| 5JNA | Crystal structure for the complex of human carbonic anhydrase IV and topiramate | x-ray diffraction | A, B, C, D | — | — |
| 5JNC | Crystal structure for the complex of human carbonic anhydrase IV and 4-aminomethylbenzene… | x-ray diffraction | A, B, C, D | ZN, 6LH, SO4 | — |
| 5JNC | Crystal structure for the complex of human carbonic anhydrase IV and 4-aminomethylbenzene… | x-ray diffraction | A, B, C, D | — | — |
| 5KU6 | Crystal structure for the complex of human carbonic anhydrase IV and methazolamide | x-ray diffraction | A, B, C, D | MZM, ZN, SO4 | — |
| 5KU6 | Crystal structure for the complex of human carbonic anhydrase IV and methazolamide | x-ray diffraction | A, B, C, D | MZM, ZN, SO4 | — |
| P22748 | AlphaFold monomer V2.0 prediction for carbonic anhydrase 4 (P22748) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 7 records
- SO4 · Sulfate ion · in 6 records
- MZM · N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide · in 2 records
- 6CC · 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzene-1-sulfonamide · in 1 record
- 6LH · 4-(aminomethyl)benzene-1-sulfonamide · in 1 record
- AZM · 5-acetamido-1,3,4-thiadiazole-2-sulfonamide · in 1 record
- EZL · 6-ethoxy-1,3-benzothiazole-2-sulfonamide · in 1 record
- TOR · [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate · in 1 record
Experiment against prediction
- 5KU6 chain C against the predicted model P22748: TM-score 1.00, RMSD 0.26 Å
- 5KU6 chain C against the predicted model P22748: TM-score 1.00, RMSD 0.26 Å
- 5JNC chain C against the predicted model P22748: TM-score 1.00, RMSD 0.26 Å
- 5JNC chain C against the predicted model P22748: TM-score 1.00, RMSD 0.26 Å
- 5JN9 chain C against the predicted model P22748: TM-score 1.00, RMSD 0.26 Å
- 5JN9 chain C against the predicted model P22748: TM-score 1.00, RMSD 0.26 Å
- 5JN8 chain C against the predicted model P22748: TM-score 1.00, RMSD 0.26 Å
- 5JN8 chain C against the predicted model P22748: TM-score 1.00, RMSD 0.26 Å
- 5JNA chain C against the predicted model P22748: TM-score 1.00, RMSD 0.28 Å
- 5JNA chain C against the predicted model P22748: TM-score 1.00, RMSD 0.28 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.