UniProt P22361
Hepatocyte nuclear factor 1-alpha (P22361)
Hepatocyte nuclear factor 1-alpha (UniProt P22361): 12 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22361
- Protein
- Hepatocyte nuclear factor 1-alpha
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 2 · 1 record with a druggable one
Structures
13 records of P22361 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F93 | Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator… | x-ray diffraction | E, F, G, H | — | — |
| 1F93 | Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator… | x-ray diffraction | E, F, G, H | — | — |
| 1G2Y | Hnf-1ALPHA dimerization domain, with selenomethionine substitued at leu 12 | x-ray diffraction | A, B, C, D | — | — |
| 1G2Y | Hnf-1ALPHA dimerization domain, with selenomethionine substitued at leu 12 | x-ray diffraction | A, B, C, D | — | — |
| 1G2Z | Dimerization domain of hnf-1ALPHA with a leu 13 selenomethionine substitution | x-ray diffraction | A, B | — | — |
| 1G2Z | Dimerization domain of hnf-1ALPHA with a leu 13 selenomethionine substitution | x-ray diffraction | A, B | — | — |
| 1G39 | Wild-type hnf-1ALPHA dimerization domain | x-ray diffraction | A, B, C, D | — | — |
| 1G39 | Wild-type hnf-1ALPHA dimerization domain | x-ray diffraction | A, B, C, D | — | — |
| 1JB6 | Crystal Structure of Dimerization Domain (1-33) of HNF-1alpha | x-ray diffraction | A, B | — | — |
| 1JB6 | Crystal structure of dimerization domain (1-33) of hnf-1ALPHA | x-ray diffraction | A, B | — | — |
| 1LFB | The X-ray structure of an atypical homeodomain present in the rat liver transcription factor… | x-ray diffraction | A | — | — |
| 1LFB | The X-ray structure of an atypical homeodomain present in the rat liver transcription factor… | x-ray diffraction | A | — | — |
| P22361 | AlphaFold monomer V2.0 prediction for hepatocyte nuclear factor 1-alpha (P22361) | predicted | A | — | 2 (best 0.54) |
Experiment against prediction
- 1LFB chain A against the predicted model P22361: TM-score 0.95, RMSD 0.73 Å
- 1LFB chain A against the predicted model P22361: TM-score 0.95, RMSD 0.73 Å
- 1G39 chain C against the predicted model P22361: TM-score 0.71, RMSD 1.43 Å
- 1G39 chain C against the predicted model P22361: TM-score 0.71, RMSD 1.43 Å
- 1G2Y chain A against the predicted model P22361: TM-score 0.71, RMSD 1.58 Å
- 1G2Y chain A against the predicted model P22361: TM-score 0.71, RMSD 1.58 Å
- 1G39 chain A against the predicted model P22361: TM-score 0.70, RMSD 1.44 Å
- 1G39 chain A against the predicted model P22361: TM-score 0.70, RMSD 1.44 Å
- 1F93 chain E against the predicted model P22361: TM-score 0.67, RMSD 1.57 Å
- 1F93 chain E against the predicted model P22361: TM-score 0.67, RMSD 1.57 Å
Elsewhere
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