UniProt P21505
Homing endonuclease I-DmoI (P21505)
Homing endonuclease I-DmoI (UniProt P21505), EC 3.1.-.-: 39 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P21505
- Protein
- Homing endonuclease I-DmoI
- EC
- 3.1.-.-
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 55 · 5 records with a druggable one
Structures
40 records of P21505 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B24 | I-dmoi, intron-encoded endonuclease | x-ray diffraction | A | — | — |
| 1B24 | I-dmoi, intron-encoded endonuclease | x-ray diffraction | A | — | — |
| 1MOW | E-DreI | x-ray diffraction | A, D, G, J | — | — |
| 1MOW | E-DREI | x-ray diffraction | A, D, G, J | — | — |
| 2VS7 | The crystal structure of I-DmoI in complex with DNA and Ca | x-ray diffraction | A, D, G | — | — |
| 2VS7 | The crystal structure of I-dmoi in complex with DNA and ca | x-ray diffraction | A, D, G | — | — |
| 2VS8 | The crystal structure of I-DmoI in complex with DNA and Mn | x-ray diffraction | A, F, K | — | — |
| 2VS8 | The crystal structure of I-dmoi in complex with DNA and mn | x-ray diffraction | A, F, K | — | — |
| 4D6N | The crystal structure of I-dmoi in complex with its target DNA at 10 days incubation in 5MM mg… | x-ray diffraction | A, F, K | — | — |
| 4D6N | The crystal structure of I-dmoi in complex with its target DNA at 10 days incubation in 5MM mg… | x-ray diffraction | A, F, K | — | — |
| 4D6O | The crystal structure of I-dmoi in complex with its target DNA at 1H incubation in 5MM mg (state 2) | x-ray diffraction | A, D, G | — | — |
| 4D6O | The crystal structure of I-dmoi in complex with its target DNA at 1H incubation in 5MM mg (state 2) | x-ray diffraction | A, D, G | — | — |
| 4UN7 | The crystal structure of I-dmoi in complex with its target DNA before incubation in 5MM mn (state 1) | x-ray diffraction | A, D, G | — | — |
| 4UN7 | The crystal structure of I-dmoi in complex with its target DNA before incubation in 5MM mn (state 1) | x-ray diffraction | A, D, G | — | — |
| 4UN8 | The crystal structure of I-dmoi in complex with its target DNA at 1H incubation in 5MM mn (state 2) | x-ray diffraction | A, D, G | — | — |
| 4UN8 | The crystal structure of I-dmoi in complex with its target DNA at 1H incubation in 5MM mn (state 2) | x-ray diffraction | A, D, G | — | — |
| 4UN9 | The crystal structure of I-dmoi in complex with its target DNA at 8H incubation in 5MM mn (state 3) | x-ray diffraction | A, D, G | — | — |
| 4UN9 | The crystal structure of I-dmoi in complex with its target DNA at 8H incubation in 5MM mn (state 3) | x-ray diffraction | A, D, G | — | — |
| 4UNA | The crystal structure of I-dmoi in complex with its target DNA at 2 days incubation in 5MM mn… | x-ray diffraction | A, D, G | — | — |
| 4UNA | The crystal structure of I-dmoi in complex with its target DNA at 2 days incubation in 5MM mn… | x-ray diffraction | A, D, G | — | — |
| 4UNB | The crystal structure of I-dmoi in complex with its target DNA at 6 days incubation in 5MM mn… | x-ray diffraction | A, D, G | — | — |
| 4UNB | The crystal structure of I-dmoi in complex with its target DNA at 6 days incubation in 5MM mn… | x-ray diffraction | A, D, G | — | — |
| 4UNC | The crystal structure of I-dmoi in complex with its target DNA at 8 days incubation in 5MM mn… | x-ray diffraction | A, D, G | — | — |
| 4UNC | The crystal structure of I-dmoi in complex with its target DNA at 8 days incubation in 5MM mn… | x-ray diffraction | A, D, G | — | — |
| 4UT0 | The crystal structure of I-dmoi in complex with its target DNA at 10 days incubation in 5MM mn… | x-ray diffraction | A, F, K | — | — |
| 4UT0 | The crystal structure of I-dmoi in complex with its target DNA at 10 days incubation in 5MM mn… | x-ray diffraction | A, F, K | — | — |
| 5A0W | The crystal structure of I-dmoi E117A in complex with its target DNA and in the presence of 2MM mn | x-ray diffraction | A, D, G | CL, MN | 10 (best 0.59) |
| 5A0W | The crystal structure of I-dmoi E117A in complex with its target DNA and in the presence of 2MM mn | x-ray diffraction | A, D, G | — | — |
| 5AK9 | The crystal structure of I-dmoi Q42AK120M in complex with its target DNA in the presence of 2MM mn | x-ray diffraction | A, E, J | MN | 9 (best 0.71) |
| 5AK9 | The crystal structure of I-dmoi Q42AK120M in complex with its target DNA in the presence of 2MM mn | x-ray diffraction | A, E, J | — | — |
| 5AKF | The crystal structure of I-dmoi Q42AK120M in complex with its target DNA nicked in the coding… | x-ray diffraction | A, E, I | CL, MN | 10 (best 0.62) |
| 5AKF | The crystal structure of I-dmoi Q42AK120M in complex with its target DNA nicked in the coding… | x-ray diffraction | A, E, I | — | — |
| 5AKM | The crystal structure of I-dmoi G20S in complex with its target DNA in the presence of 2MM mg | x-ray diffraction | A, F, K | MG | 14 (best 0.54) |
| 5AKM | The crystal structure of I-dmoi G20S in complex with its target DNA in the presence of 2MM mg | x-ray diffraction | A, F, K | — | — |
| 5AKN | THE CRYSTAL STRUCTURE OF I-DMOI Q42AK120M IN COMPLEX WITH ITS TARGET DNA NICKED IN THE non-CODING… | x-ray diffraction | A, F, K | — | — |
| 5AKN | The crystal structure of I-dmoi Q42AK120M in complex with its target DNA nicked in the non-coding… | x-ray diffraction | A, F, K | — | — |
| 5O6G | Structures and dynamics of mesophilic variants from the homing endonuclease I-DmoI | x-ray diffraction | A, D, G | MN, CL | 12 (best 0.56) |
| 5O6G | Structures and dynamics of mesophilic variants from the homing endonuclease I-dmoi | x-ray diffraction | A, D, G | MN, CL | — |
| 5O6I | Structures and dynamics of mesophilic variants from the homing endonuclease I-dmoi | x-ray diffraction | A, F, K | MN, CL | — |
| P21505 | AlphaFold monomer V2.0 prediction for homing endonuclease I-dmoi (P21505) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5AKF chain E against the predicted model P21505: TM-score 1.00, RMSD 0.28 Å
- 5AKF chain E against the predicted model P21505: TM-score 1.00, RMSD 0.28 Å
- 5A0W chain G against the predicted model P21505: TM-score 1.00, RMSD 0.29 Å
- 5A0W chain G against the predicted model P21505: TM-score 1.00, RMSD 0.29 Å
- 2VS7 chain A against the predicted model P21505: TM-score 1.00, RMSD 0.31 Å
- 2VS7 chain A against the predicted model P21505: TM-score 1.00, RMSD 0.31 Å
- 4UNA chain G against the predicted model P21505: TM-score 1.00, RMSD 0.32 Å
- 4UNA chain G against the predicted model P21505: TM-score 1.00, RMSD 0.32 Å
- 2VS7 chain G against the predicted model P21505: TM-score 1.00, RMSD 0.34 Å
- 2VS7 chain G against the predicted model P21505: TM-score 1.00, RMSD 0.34 Å
Elsewhere
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