UniProt P20963
T-cell surface glycoprotein CD3 zeta chain (P20963)
T-cell surface glycoprotein CD3 zeta chain (UniProt P20963): 31 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P20963
- Protein
- T-cell surface glycoprotein CD3 zeta chain
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 28 · 12 records with a druggable one
Structures
32 records of P20963 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TCE | Solution NMR structure of the shc SH2 domain complexed with a tyrosine-phosphorylated peptide from… | solution nmr | B | — | — |
| 1TCE | Solution NMR structure of the shc SH2 domain complexed with a tyrosine-phosphorylated peptide from… | solution nmr | B | — | — |
| 1YGR | Crystal structure of the tandem phosphatase domain of RPTP CD45 | x-ray diffraction | C, D | — | — |
| 1YGR | Crystal structure of the tandem phosphatase domain of rptp CD45 | x-ray diffraction | C, D | — | — |
| 2HAC | Structure of Zeta-Zeta Transmembrane Dimer | solution nmr | A, B | — | — |
| 2HAC | Structure of zeta-zeta transmembrane dimer | solution nmr | A, B | — | — |
| 2OQ1 | Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide | x-ray diffraction | B | — | — |
| 2OQ1 | Tandem SH2 domains of zap-70 with 19-mer ZETA1 peptide | x-ray diffraction | B | — | — |
| 3IK5 | SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80) | x-ray diffraction | D, B | — | — |
| 3IK5 | SIVMAC239 nef in complex with TCR zeta itam 1 polypeptide (A63-R80) | x-ray diffraction | D, B | — | — |
| 3IOZ | SIVmac239 Nef in complex with a TCR zeta polypeptide DP1 (L51-D93) | x-ray diffraction | B | — | — |
| 3IOZ | SIVMAC239 nef in complex with a TCR zeta polypeptide DP1 (L51-D93) | x-ray diffraction | B | — | — |
| 6JXR | Structure of human T cell receptor-CD3 complex | electron microscopy | a, b | — | — |
| 6JXR | Structure of human T cell receptor-CD3 complex | electron microscopy | a, b | — | — |
| 7FJD | Cryo-EM structure of a membrane protein(WT) | electron microscopy | a, b | CLR | 1 (best 0.84) |
| 7FJD | Cryo-EM structure of a membrane PROTEIN(WT) | electron microscopy | a, b | CLR | — |
| 7FJE | Cryo-EM structure of a membrane PROTEIN(LL) | electron microscopy | a, b | CLR | — |
| 7FJF | Cryo-EM structure of a membrane protein(CS) | electron microscopy | b, a | C3S | 1 (best 0.84) |
| 7FJF | Cryo-EM structure of a membrane PROTEIN(CS) | electron microscopy | b, a | C3S | — |
| 7PHR | Structure of a fully assembled T-cell receptor engaging a tumor-associated peptide-MHC I | electron microscopy | Z, z | — | 2 (best 0.83) |
| 7PHR | Structure of a fully assembled T-cell receptor engaging a tumor- associated peptide-MHC I | electron microscopy | Z, z | — | — |
| 8J8I | Membrane-bound structure of CD3z cytoplasmic domain | solution nmr | A | — | — |
| 8JC0 | V gamma9 V delta2 TCR and CD3 complex in LMNG | electron microscopy | a, b | CLR | 1 (best 0.82) |
| 8JCB | Vgamma5 Vdelta1 T cell receptor complex | electron microscopy | A, B, a, b | — | 4 (best 0.76) |
| 8TW6 | TCR in nanodisc ND-II | electron microscopy | Y, X | CLR | 2 (best 0.79) |
| 8WXE | Vgamma5Vdelta1 EH TCR-CD3 complex | electron microscopy | a, b | CLR | 5 (best 0.76) |
| 8WY0 | T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A | electron microscopy | a, b | CLR | 2 (best 0.82) |
| 8WYI | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | electron microscopy | a, b | — | 2 (best 0.82) |
| 8YC0 | T cell receptor V delta2 V gamma9 in GDN | electron microscopy | a, b | CLR | 2 (best 0.81) |
| 9C3E | TCR - CD3 complex bound to HLA | electron microscopy | X, Y | CLR | 3 (best 0.82) |
| 9CIA | T cell receptor complex | electron microscopy | a, b | CLR | 3 (best 0.78) |
| P20963 | P20963 | predicted | A | — | — |
Ligands
Experiment against prediction
- 9C3E chain Y against the predicted model P20963: TM-score 0.86, RMSD 0.45 Å
- 7PHR chain z against the predicted model P20963: TM-score 0.84, RMSD 1.08 Å
- 7PHR chain z against the predicted model P20963: TM-score 0.84, RMSD 1.08 Å
- 8WXE chain b against the predicted model P20963: TM-score 0.83, RMSD 1.05 Å
- 8YC0 chain b against the predicted model P20963: TM-score 0.82, RMSD 0.61 Å
- 9CIA chain b against the predicted model P20963: TM-score 0.81, RMSD 1.25 Å
- 8WYI chain a against the predicted model P20963: TM-score 0.80, RMSD 1.09 Å
- 8WYI chain b against the predicted model P20963: TM-score 0.80, RMSD 0.69 Å
- 7FJD chain b against the predicted model P20963: TM-score 0.78, RMSD 0.67 Å
- 7FJD chain b against the predicted model P20963: TM-score 0.78, RMSD 0.67 Å
Elsewhere
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