UniProt P20309
Muscarinic acetylcholine receptor M3 (P20309)
Muscarinic acetylcholine receptor M3 (UniProt P20309): 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P20309
- Protein
- Muscarinic acetylcholine receptor M3
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 18 · 4 records with a druggable one
Structures
7 records of P20309 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CSA | Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal | solution nmr | A | — | — |
| 2CSA | Structure of the M3 muscarinic acetylcholine receptor basolateral sorting signal | solution nmr | A | — | — |
| 8E9W | CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ | electron microscopy | A | WEC | 3 (best 0.76) |
| 8E9Y | CryoEM structure of miniGq-coupled hM3Dq in complex with CNO | electron microscopy | A | WE9 | 5 (best 0.81) |
| 8E9Z | CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo | electron microscopy | A | IXO, Y01 | 6 (best 0.79) |
| 8EA0 | CryoEM structure of miniGq-coupled hM3R in complex with iperoxo (local refinement) | electron microscopy | A | IXO, Y01 | 4 (best 0.78) |
| P20309 | AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M3 (P20309) | predicted | A | — | — |
Ligands
- IXO · 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- WE9 · 8-chloro-11-(4-methyl-4-oxo-4lambda~5~-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine · in 1 record
- WEC · 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine · in 1 record
Experiment against prediction
- 8E9Y chain A against the predicted model P20309: TM-score 0.96, RMSD 1.58 Å
- 8E9W chain A against the predicted model P20309: TM-score 0.95, RMSD 1.72 Å
- 8E9Z chain A against the predicted model P20309: TM-score 0.95, RMSD 1.71 Å
- 8EA0 chain A against the predicted model P20309: TM-score 0.95, RMSD 1.71 Å
- 2CSA chain A against the predicted model P20309: TM-score 0.21, RMSD 2.65 Å
- 2CSA chain A against the predicted model P20309: TM-score 0.21, RMSD 2.65 Å
Elsewhere
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