UniProt P20138
Myeloid cell surface antigen CD33 (P20138)
Myeloid cell surface antigen CD33 (UniProt P20138): 13 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P20138
- Protein
- Myeloid cell surface antigen CD33
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 17 · 2 records with a druggable one
Structures
14 records of P20138 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5IHB | Structure of the immune receptor CD33 | x-ray diffraction | A, B, C, D | NAG | 6 (best 0.54) |
| 5IHB | Structure of the immune receptor CD33 | x-ray diffraction | A, B, C, D | — | — |
| 5J06 | Structure of the immune receptor CD33 in complex with 3'-sialyllactose | x-ray diffraction | A, B, C, D | SIA, NAG | 5 (best 0.59) |
| 5J06 | Structure of the immune receptor CD33 in complex with 3'-sialyllactose | x-ray diffraction | A, B, C, D | — | — |
| 5J0B | Structure of the immune receptor CD33 in complex with 6'-sialyllactose | x-ray diffraction | A, B, C, D | — | — |
| 6D48 | Cell Surface Receptor | x-ray diffraction | E, F, G, H | — | 4 (best 0.37) |
| 6D48 | Cell surface receptor | x-ray diffraction | E, F, G, H | — | — |
| 6D49 | Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution | x-ray diffraction | A, B | FVP | 1 (best 0.48) |
| 6D49 | Cell surface receptor in complex with ligand at 1.80-a resolution | x-ray diffraction | A, B | FVP | — |
| 6D4A | Cell surface receptor with bound ligand at 1.75-a resolution | x-ray diffraction | A, B | FVP | — |
| 6TL8 | Structural basis of SALM3 dimerization and adhesion complex formation with the presynaptic receptor… | x-ray diffraction | A, B, C, D | NAG | — |
| 7AW6 | The extracellular region of CD33 with bound sialoside analogue P22 | x-ray diffraction | A, B | NAG, FVP, PO4 | 1 (best 0.37) |
| 7AW6 | The extracellular region of CD33 with bound sialoside analogue P22 | x-ray diffraction | A, B | NAG, FVP, PO4 | — |
| P20138 | AlphaFold monomer V2.0 prediction for myeloid cell surface antigen CD33 (P20138) | predicted | A | — | — |
Ligands
- FVP · 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl) acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- PO4 · Phosphate ion · in 2 records
- SIA · N-acetyl-alpha-neuraminic acid · in 1 record
Experiment against prediction
- 5J0B chain D against the predicted model P20138: TM-score 0.99, RMSD 0.57 Å
- 5IHB chain D against the predicted model P20138: TM-score 0.99, RMSD 0.58 Å
- 5IHB chain D against the predicted model P20138: TM-score 0.99, RMSD 0.58 Å
- 5J06 chain D against the predicted model P20138: TM-score 0.99, RMSD 0.60 Å
- 5J06 chain D against the predicted model P20138: TM-score 0.99, RMSD 0.60 Å
- 6D4A chain A against the predicted model P20138: TM-score 0.99, RMSD 0.47 Å
- 6D48 chain E against the predicted model P20138: TM-score 0.99, RMSD 0.50 Å
- 6D48 chain E against the predicted model P20138: TM-score 0.99, RMSD 0.50 Å
- 7AW6 chain A against the predicted model P20138: TM-score 0.99, RMSD 0.77 Å
- 7AW6 chain A against the predicted model P20138: TM-score 0.99, RMSD 0.77 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.