UniProt P19573
Nitrous-oxide reductase (P19573)
Nitrous-oxide reductase (UniProt P19573), EC 1.7.2.4: 37 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 74 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P19573
- Protein
- Nitrous-oxide reductase
- EC
- 1.7.2.4
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 74 · 11 records with a druggable one
Structures
38 records of P19573 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SBP | Pseudomonas stutzeri nitrous oxide reductase, P1 crystal form | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3SBP | Pseudomonas stutzeri nitrous oxide reductase, P1 crystal form | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3SBQ | Pseudomonas stutzeri nitrous oxide reductase, P65 crystal form | x-ray diffraction | A, B | — | — |
| 3SBQ | Pseudomonas stutzeri nitrous oxide reductase, P65 crystal form | x-ray diffraction | A, B | — | — |
| 3SBR | Pseudomonas stutzeri nitrous oxide reductase, P1 crystal form with substrate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3SBR | Pseudomonas stutzeri nitrous oxide reductase, P1 crystal form with substrate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6RKZ | Recombinant Pseudomonas stutzeri nitrous oxide reductase, form II | x-ray diffraction | A, B | NA, CA, K, CL, CUZ, CUA | 5 (best 0.79) |
| 6RKZ | Recombinant pseudomonas stutzeri nitrous oxide reductase, form II | x-ray diffraction | A, B | NA, CA, K, CL, CUZ, CUA | — |
| 6RL0 | Recombinant Pseudomonas stutzeri nitrous oxide reductase, form I | x-ray diffraction | A, B, C, D | CL, CA, CUK, CUA, K, NA | 13 (best 0.80) |
| 6RL0 | Recombinant pseudomonas stutzeri nitrous oxide reductase, form I | x-ray diffraction | A, B, C, D | CL, CA, CUK, CUA, K, NA | — |
| 6Y6Y | Pseudomonas stutzeri nitrous oxide reductase mutant, H129A | x-ray diffraction | A, B | ZN, NA, CL, CUA, CA | — |
| 6Y6Y | Pseudomonas stutzeri nitrous oxide reductase mutant, H129A | x-ray diffraction | A, B | ZN, NA, CL, CUA, CA | — |
| 6Y71 | Pseudomonas stutzeri nitrous oxide reductase mutant, H130A | x-ray diffraction | A, B | NA, CA, CL, CUA | — |
| 6Y72 | Pseudomonas stutzeri nitrous oxide reductase mutant, H178A | x-ray diffraction | A, B | NA, CA, CL, CUA, K | 8 (best 0.80) |
| 6Y72 | Pseudomonas stutzeri nitrous oxide reductase mutant, H178A | x-ray diffraction | A, B | NA, CA, CL, CUA, K | — |
| 6Y77 | Pseudomonas stutzeri nitrous oxide reductase mutant, H326A | x-ray diffraction | A, B | ZN, CUA, NA | — |
| 6Y7D | Pseudomonas stutzeri nitrous oxide reductase mutant, H433A | x-ray diffraction | A, B | NA, CL, CUA, CA | — |
| 6Y7E | Pseudomonas stutzeri nitrous oxide reductase mutant, H494A | x-ray diffraction | A, B | ZN, NA, CL, CUA, CA | — |
| 7APY | Pseudomonas stutzeri nitrous oxide reductase mutant, D576A | x-ray diffraction | A, B | NA, CA, K, CL, CUZ, CUA | 6 (best 0.79) |
| 7APY | Pseudomonas stutzeri nitrous oxide reductase mutant, D576A | x-ray diffraction | A, B | NA, CA, K, CL, CUZ, CUA | — |
| 7AQ0 | Pseudomonas stutzeri nitrous oxide reductase mutant, D576A/S550A | x-ray diffraction | A, B | NA, CA, CL, CUZ, CUA, K | 5 (best 0.80) |
| 7AQ0 | Pseudomonas stutzeri nitrous oxide reductase mutant, D576A/S550A | x-ray diffraction | A, B | NA, CA, CL, CUZ, CUA, K | — |
| 7AQ2 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583A | x-ray diffraction | A, B | ZN, NA, CL, CUA, CA, K | — |
| 7AQ3 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583D | x-ray diffraction | A, B | NA, CL, CUA, ZN, CA, K | — |
| 7AQ4 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583E | x-ray diffraction | A, B | NA, CA, CL, CUA, ZN, K | 6 (best 0.81) |
| 7AQ4 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583E | x-ray diffraction | A, B | NA, CA, CL, CUA, ZN, K | — |
| 7AQ5 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583N | x-ray diffraction | A, B | NA, CA, CL, CUA, ZN, K | 7 (best 0.81) |
| 7AQ5 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583N | x-ray diffraction | A, B | NA, CA, CL, CUA, ZN, K | — |
| 7AQ6 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583F | x-ray diffraction | A, B | NA, CA, K, CL, CUZ, CUA | — |
| 7AQ7 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583Y | x-ray diffraction | A, B | NA, CA, K, CL, CUZ, CUA | 5 (best 0.80) |
| 7AQ7 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583Y | x-ray diffraction | A, B | NA, CA, K, CL, CUZ, CUA | — |
| 7AQ8 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583Y/D576A | x-ray diffraction | A, B | NA, CA, K, CL, CUA, ZN | 7 (best 0.80) |
| 7AQ8 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583Y/D576A | x-ray diffraction | A, B | NA, CA, K, CL, CUA, ZN | — |
| 7AQ9 | Pseudomonas stutzeri nitrous oxide reductase mutant, H583W | x-ray diffraction | A, B | NA, CL, CUA, ZN, CA, K | — |
| 7AQA | Pseudomonas stutzeri nitrous oxide reductase mutant, H382A | x-ray diffraction | A, B | K7E, NA, CA, K, CL, CUA | — |
| 7QBA | CryoEM structure of the ABC transporter NosDFY complexed with nitrous oxide reductase NosZ | electron microscopy | H, I | CA | 10 (best 0.77) |
| 7QBA | Cryoem structure of the ABC transporter nosdfy complexed with nitrous oxide reductase nosz | electron microscopy | H, I | CA | — |
| P19573 | AlphaFold monomer V2.0 prediction for nitrous-oxide reductase (P19573) | predicted | A | — | 2 (best 0.60) |
Ligands
- CA · Calcium ion · in 30 records
- CUA · Dinuclear copper ion · in 29 records
- NA · Sodium ion · in 29 records
- CL · Chloride ion · in 28 records
- K · Potassium ion · in 23 records
- CUZ · (mu-4-sulfido)-tetra-nuclear copper ion · in 18 records
- ZN · Zinc ion · in 13 records
- CUK · [4Cu:2S] cluster · in 2 records
- K7E · Sulfanyl-(tricuprio-$L^{4}-sulfanyl)copper · in 1 record
- PHE · Phenylalanine · in 1 record
- RUQ · (dicuprio-$L^{3}-sulfanyl)-sulfanyl-copper · in 1 record
Experiment against prediction
- 6RL0 chain D against the predicted model P19573: TM-score 1.00, RMSD 0.35 Å
- 6RL0 chain D against the predicted model P19573: TM-score 1.00, RMSD 0.35 Å
- 3SBQ chain A against the predicted model P19573: TM-score 1.00, RMSD 0.39 Å
- 3SBQ chain A against the predicted model P19573: TM-score 1.00, RMSD 0.39 Å
- 6Y77 chain A against the predicted model P19573: TM-score 1.00, RMSD 0.39 Å
- 6RL0 chain C against the predicted model P19573: TM-score 1.00, RMSD 0.40 Å
- 6RL0 chain C against the predicted model P19573: TM-score 1.00, RMSD 0.40 Å
- 3SBR chain A against the predicted model P19573: TM-score 1.00, RMSD 0.41 Å
- 3SBR chain A against the predicted model P19573: TM-score 1.00, RMSD 0.41 Å
- 3SBP chain A against the predicted model P19573: TM-score 1.00, RMSD 0.43 Å
Elsewhere
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