UniProt P19440
Gamma-glutamyltranspeptidase 1 (P19440)
Gamma-glutamyltranspeptidase 1 (UniProt P19440), EC 2.3.2.2, 3.4.19.13: 19 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P19440
- Protein
- Gamma-glutamyltranspeptidase 1
- EC
- 2.3.2.2, 3.4.19.13, 3.4.19.14
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 8 · 2 records with a druggable one
Structures
20 records of P19440 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4GDX | Crystal Structure of Human Gamma-Glutamyl Transpeptidase--Glutamate complex | x-ray diffraction | A, B | — | — |
| 4GDX | Crystal structure of human gamma-glutamyl transpeptidase--glutamate complex | x-ray diffraction | A, B | — | — |
| 4GG2 | The crystal structure of glutamate-bound human gamma-glutamyltranspeptidase 1 | x-ray diffraction | A, B | — | — |
| 4GG2 | The crystal structure of glutamate-bound human gamma- glutamyltranspeptidase 1 | x-ray diffraction | A, B | — | — |
| 4Z9O | Crystal Structure of human GGT1 | x-ray diffraction | A, B | — | — |
| 4Z9O | Crystal structure of human GGT1 | x-ray diffraction | A, B | — | — |
| 4ZBK | Crystal Structure of human GGT1 in complex with GGsTop inhibitor | x-ray diffraction | A, B | NAG, CL, NA, 4M8 | 4 (best 0.75) |
| 4ZBK | Crystal structure of human GGT1 in complex with ggstop inhibitor | x-ray diffraction | A, B | — | — |
| 4ZC6 | Crystal Structure of human GGT1 in complex with Serine Borate | x-ray diffraction | A, B | — | — |
| 4ZC6 | Crystal structure of human GGT1 in complex with serine borate | x-ray diffraction | A, B | — | — |
| 4ZCG | Crystal Structure of human GGT1 in complex with Glutamate (with all atoms of glutamate) | x-ray diffraction | A, B | — | — |
| 4ZCG | Crystal structure of human GGT1 in complex with glutamate (with all atoms of glutamate) | x-ray diffraction | A, B | — | — |
| 5V4Q | Crystal structure of human GGT1 in complex with don | x-ray diffraction | A, B | NAG, CL, NA | — |
| 6XPB | Structure of human GGT1 in complex with 2-amino-4-(((1… | x-ray diffraction | A, B | NAG, CL, NA, V7D | — |
| 6XPC | Structure of human GGT1 in complex with full gsh molecule | x-ray diffraction | A, B | NAG, CL, NA, GSH | — |
| 7LA5 | Structure of human GGT1 in complex with LNT1-172 compound. | x-ray diffraction | A, B | NAG, CL, XSM | — |
| 7LBC | Structure of human GGT1 in complex with Lnt2-65 compound | x-ray diffraction | A, B | NAG, CL, XSA, SO4 | 4 (best 0.75) |
| 7LBC | Structure of human GGT1 in complex with LNT2-65 compound | x-ray diffraction | A, B | NAG, CL, XSA, SO4 | — |
| 7LD9 | Structure of human GGT1 in complex with abba | x-ray diffraction | A, B | NAG, CL, NA, XUJ, XU7 | — |
| P19440 | AlphaFold monomer V2.0 prediction for glutathione hydrolase 1 proenzyme (P19440) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 8 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- NA · Sodium ion · in 5 records
- SO4 · Sulfate ion · in 2 records
- XSA · (2R)-2-[(2-aminoethyl)amino]-4-boronobutanoic acid · in 2 records
- 4M8 · (2S)-2-amino-4-[(S)-hydroxy(methoxy)phosphoryl]butanoic acid · in 1 record
- GSH · Glutathione · in 1 record
- V7D · 2,2-diamino-4-[(S)-({(2S)-1-[(carboxymethyl)amino]-1-oxobutan-2-yl}oxy)(hydroxy)phosphanyl]butanoic acid · in 1 record
- XSM · (2R)-4-borono-2-{[(1H-imidazol-4-yl) methyl]amino}butanoic acid · in 1 record
- XU7 · (2S)-2-amino-4-boronobutanoic acid · in 1 record
- XUJ · (2R)-2-amino-4-boronobutanoic acid · in 1 record
Experiment against prediction
- 4ZC6 chain A against the predicted model P19440: TM-score 0.99, RMSD 0.80 Å
- 4ZC6 chain A against the predicted model P19440: TM-score 0.99, RMSD 0.80 Å
- 4GDX chain A against the predicted model P19440: TM-score 0.99, RMSD 0.74 Å
- 4GDX chain A against the predicted model P19440: TM-score 0.99, RMSD 0.74 Å
- 6XPC chain A against the predicted model P19440: TM-score 0.99, RMSD 0.80 Å
- 4ZBK chain A against the predicted model P19440: TM-score 0.99, RMSD 0.82 Å
- 4ZBK chain A against the predicted model P19440: TM-score 0.99, RMSD 0.82 Å
- 4Z9O chain A against the predicted model P19440: TM-score 0.99, RMSD 0.81 Å
- 4Z9O chain A against the predicted model P19440: TM-score 0.99, RMSD 0.81 Å
- 4ZCG chain A against the predicted model P19440: TM-score 0.99, RMSD 0.84 Å
Elsewhere
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