UniProt P18615
Negative elongation factor E (P18615)
Negative elongation factor E (UniProt P18615): 11 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P18615
- Protein
- Negative elongation factor E
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 1 · 1 record with a druggable one
Structures
12 records of P18615 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X5P | Solution structure of RRM domain in Parp14 | solution nmr | A | — | — |
| 1X5P | Solution structure of rrm domain in PARP14 | solution nmr | A | — | — |
| 2BZ2 | Solution structure of NELF E RRM | solution nmr | A | — | — |
| 2BZ2 | Solution structure of nelf E rrm | solution nmr | A | — | — |
| 2JX2 | Solution conformation of RNA-bound NELF-E RRM | solution nmr | A | — | — |
| 2JX2 | Solution conformation of RNA-bound nelf-E rrm | solution nmr | A | — | — |
| 5OOB | Complex of human nuclear cap-binding complex with M7GTP and nelf-E C-terminal peptide | x-ray diffraction | E, K, Z | — | — |
| 5OOB | Complex of human nuclear cap-binding complex with M7GTP and nelf-E C- terminal peptide | x-ray diffraction | E, K, Z | — | — |
| 6GML | Structure of paused transcription complex pol II-dsif-nelf | electron microscopy | X | — | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | h | — | — |
| 8W8E | human co-transcriptional RNA capping enzyme RNGTT | electron microscopy | X | — | 1 (best 0.74) |
| P18615 | AlphaFold monomer V2.0 prediction for negative elongation factor E (P18615) | predicted | A | — | — |
Experiment against prediction
- 8W8E chain X against the predicted model P18615: TM-score 1.00, RMSD 0.11 Å
- 2BZ2 chain A against the predicted model P18615: TM-score 0.83, RMSD 1.65 Å
- 2BZ2 chain A against the predicted model P18615: TM-score 0.83, RMSD 1.65 Å
- 2JX2 chain A against the predicted model P18615: TM-score 0.79, RMSD 2.06 Å
- 2JX2 chain A against the predicted model P18615: TM-score 0.79, RMSD 2.06 Å
- 1X5P chain A against the predicted model P18615: TM-score 0.76, RMSD 1.84 Å
- 1X5P chain A against the predicted model P18615: TM-score 0.76, RMSD 1.84 Å
- 7YCX chain h against the predicted model P18615: TM-score 0.67, RMSD 0.76 Å
- 6GML chain X against the predicted model P18615: TM-score 0.62, RMSD 1.07 Å
- 5OOB chain Z against the predicted model P18615: TM-score 0.27, RMSD 2.74 Å
Elsewhere
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