UniProt P18422
Proteasome subunit alpha type-3 (P18422)
Proteasome subunit alpha type-3 (UniProt P18422), EC 3.4.25.1: 10 experimental structures and 1 predicted model on GenesisL1, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P18422
- Protein
- Proteasome subunit alpha type-3
- EC
- 3.4.25.1
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 19 · 5 records with a druggable one
Structures
11 records of P18422 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EPC | Ground state 26S proteasome (GS2) | electron microscopy | G | — | 4 (best 0.88) |
| 6EPC | Ground state 26S proteasome (GS2) | electron microscopy | G | — | — |
| 6EPD | Substrate processing state 26S proteasome (SPS1) | electron microscopy | G | — | 3 (best 0.81) |
| 6EPD | Substrate processing state 26S proteasome (SPS1) | electron microscopy | G | — | — |
| 6EPE | Substrate processing state 26S proteasome (SPS2) | electron microscopy | G | — | 2 (best 0.86) |
| 6EPE | Substrate processing state 26S proteasome (SPS2) | electron microscopy | G | — | — |
| 6EPF | Ground state 26S proteasome (GS1) | electron microscopy | G | — | 4 (best 0.90) |
| 6EPF | Ground state 26S proteasome (GS1) | electron microscopy | G | — | — |
| 6TU3 | Rat 20S proteasome | electron microscopy | G, U | — | 3 (best 0.74) |
| 6TU3 | Rat 20S proteasome | electron microscopy | G, U | — | — |
| P18422 | AlphaFold monomer V2.0 prediction for proteasome subunit alpha type-3 (P18422) | predicted | A | — | 3 (best 0.45) |
Experiment against prediction
- 6TU3 chain G against the predicted model P18422: TM-score 0.99, RMSD 0.70 Å
- 6TU3 chain G against the predicted model P18422: TM-score 0.99, RMSD 0.70 Å
- 6TU3 chain U against the predicted model P18422: TM-score 0.99, RMSD 0.70 Å
- 6EPF chain G against the predicted model P18422: TM-score 0.94, RMSD 1.64 Å
- 6EPF chain G against the predicted model P18422: TM-score 0.94, RMSD 1.64 Å
- 6EPE chain G against the predicted model P18422: TM-score 0.93, RMSD 1.84 Å
- 6EPE chain G against the predicted model P18422: TM-score 0.93, RMSD 1.84 Å
- 6EPC chain G against the predicted model P18422: TM-score 0.93, RMSD 1.65 Å
- 6EPC chain G against the predicted model P18422: TM-score 0.93, RMSD 1.65 Å
- 6EPD chain G against the predicted model P18422: TM-score 0.92, RMSD 1.93 Å
Elsewhere
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