UniProt P18089
Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor (P18089)
Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor (UniProt P18089), EC 3.2.1.17: 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding…
- UniProt
- P18089
- Protein
- Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B…
- EC
- 3.2.1.17
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
4 records of P18089 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6K41 | Cryo-EM structure of ALPHA2BAR-goa complex | electron microscopy | R | CZX | — |
| 6K42 | cryo-EM structure of alpha2BAR-Gi1 complex | electron microscopy | R | CZX | 7 (best 0.80) |
| 6K42 | Cryo-EM structure of ALPHA2BAR-GI1 complex | electron microscopy | R | CZX | — |
| P18089 | AlphaFold monomer V2.0 prediction for alpha-2B adrenergic receptor (P18089) | predicted | A | — | — |
Ligands
- CZX · 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole · in 3 records
Experiment against prediction
- 6K41 chain R against the predicted model P18089: TM-score 0.93, RMSD 2.13 Å
- 6K41 chain R against the predicted model Q28838: TM-score 0.91, RMSD 2.34 Å
- 6K42 chain R against the predicted model P18089: TM-score 0.91, RMSD 2.40 Å
- 6K42 chain R against the predicted model P18089: TM-score 0.91, RMSD 2.40 Å
- 6K42 chain R against the predicted model P08913: TM-score 0.90, RMSD 2.22 Å
- 6K42 chain R against the predicted model P08913: TM-score 0.90, RMSD 2.22 Å
Elsewhere
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