UniProt P18054
Polyunsaturated fatty acid lipoxygenase ALOX12 (P18054)
Polyunsaturated fatty acid lipoxygenase ALOX12 (UniProt P18054), EC 1.13.11.-, 1.13.11.31: 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 25 pockets. Binding sites, druggability and experiment…
- UniProt
- P18054
- Protein
- Polyunsaturated fatty acid lipoxygenase ALOX12
- EC
- 1.13.11.-, 1.13.11.31, 1.13.11.33, 3.3.2.-
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 25 · 2 records with a druggable one
Structures
5 records of P18054 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3D3L | The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase… | x-ray diffraction | A, B | — | — |
| 3D3L | The 2.6 a crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase… | x-ray diffraction | A, B | — | — |
| 8GHB | The structure of h12-LOX in monomeric form | electron microscopy | A | FE2 | 5 (best 0.71) |
| 8GHD | The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid | electron microscopy | A, B, C, D, E, F | FE2, ZR5, ACD | 20 (best 0.84) |
| P18054 | AlphaFold monomer V2.0 prediction for polyunsaturated fatty acid lipoxygenase ALOX12 (P18054) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8GHB chain A against the predicted model P18054: TM-score 0.99, RMSD 1.15 Å
- 8GHD chain F against the predicted model P18054: TM-score 0.99, RMSD 1.26 Å
- 8GHD chain B against the predicted model P18054: TM-score 0.99, RMSD 1.26 Å
- 8GHD chain E against the predicted model P18054: TM-score 0.99, RMSD 1.26 Å
- 8GHD chain C against the predicted model P18054: TM-score 0.99, RMSD 1.26 Å
- 8GHD chain A against the predicted model P18054: TM-score 0.99, RMSD 1.26 Å
- 8GHD chain D against the predicted model P18054: TM-score 0.99, RMSD 1.27 Å
- 3D3L chain B against the predicted model P18054: TM-score 0.95, RMSD 2.20 Å
- 3D3L chain B against the predicted model P18054: TM-score 0.95, RMSD 2.20 Å
- 3D3L chain A against the predicted model P18054: TM-score 0.95, RMSD 2.20 Å
Elsewhere
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