UniProt P17612
cAMP-dependent protein kinase catalytic subunit alpha (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (UniProt P17612), EC 2.7.11.11: 78 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 39 pockets. Binding sites, druggability and experiment against…
- UniProt
- P17612
- Protein
- cAMP-dependent protein kinase catalytic subunit alpha
- EC
- 2.7.11.11
- Experimental structures
- 78
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 39 · 4 records with a druggable one
Structures
79 records of P17612 in the MolNFT archive: 78 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GU8 | Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and… | x-ray diffraction | A | — | — |
| 2GU8 | Discovery of 2-pyrimidyl-5-amidothiophenes as novel and potent inhibitors for AKT: synthesis and… | x-ray diffraction | A | — | — |
| 3AGL | Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1039 | x-ray diffraction | A, B | — | — |
| 3AGL | Complex of PKA with the bisubstrate protein kinase inhibitor arc-1039 | x-ray diffraction | A, B | — | — |
| 3AGM | Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670 | x-ray diffraction | A | — | — |
| 3AGM | Complex of PKA with the bisubstrate protein kinase inhibitor arc-670 | x-ray diffraction | A | — | — |
| 3AMA | Protein kinase A sixfold mutant model of Aurora B with inhibitor JNJ-7706621 | x-ray diffraction | A | — | — |
| 3AMA | Protein kinase a sixfold mutant model of aurora B with inhibitor jnj- 7706621 | x-ray diffraction | A | — | — |
| 3AMB | Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680 | x-ray diffraction | A | — | — |
| 3AMB | Protein kinase a sixfold mutant model of aurora B with inhibitor vx- 680 | x-ray diffraction | A | — | — |
| 3L9L | Crystal structure of pka with compound 36 | x-ray diffraction | A, B | — | — |
| 3L9L | Crystal structure of PKA with compound 36 | x-ray diffraction | A, B | — | — |
| 3L9M | Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18 | x-ray diffraction | A, B | — | — |
| 3L9M | Crystal structure of PKAB3 (PKA triple mutant V123A, L173M, Q181K) with compound 18 | x-ray diffraction | A, B | — | — |
| 3L9N | crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27 | x-ray diffraction | A | — | — |
| 3L9N | Crystal structure of PKAB3 (PKA triple mutant V123A, L173M, Q181K) with compound 27 | x-ray diffraction | A | — | — |
| 3MVJ | Human cyclic AMP-dependent protein kinase PKA inhibitor complex | x-ray diffraction | A, B, E | — | — |
| 3MVJ | Human cyclic AMP-dependent protein kinase PKA inhibitor complex | x-ray diffraction | A, B, E | — | — |
| 3NX8 | human cAMP dependent protein kinase in complex with phenol | x-ray diffraction | A | — | — |
| 3NX8 | Human camp dependent protein kinase in complex with phenol | x-ray diffraction | A | — | — |
| 3OOG | human cAMP-dependent protein kinase in complex with a small fragment | x-ray diffraction | A | — | — |
| 3OOG | Human camp-dependent protein kinase in complex with a small fragment | x-ray diffraction | A | — | — |
| 3OVV | Human cAMP-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3OVV | Human camp-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3OWP | Human cAMP-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3OWP | Human camp-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3OXT | Human cAMP-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3OXT | Human camp-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3P0M | Human cAMP-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3P0M | Human camp-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3POO | human cAMP-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3POO | Human camp-dependent protein kinase in complex with an inhibitor | x-ray diffraction | A | — | — |
| 3VQH | Bromine SAD partially resolves multiple binding modes for PKA inhibitor H-89 | x-ray diffraction | A | — | — |
| 3VQH | Bromine sad partially resolves multiple binding modes for PKA inhibitor H-89 | x-ray diffraction | A | — | — |
| 4AE6 | Structure and Function of the Human Sperm-Specific Isoform of Protein Kinase A (PKA) Catalytic… | x-ray diffraction | A, B | — | — |
| 4AE6 | Structure and function of the human sperm-specific isoform of protein kinase a (PKA) catalytic… | x-ray diffraction | A, B | — | — |
| 4AE9 | Structure and function of the Human Sperm-Specific Isoform of Protein Kinase A (PKA) Catalytic… | x-ray diffraction | A, B | — | — |
| 4AE9 | Structure and function of the human sperm-specific isoform of protein kinase a (PKA) catalytic… | x-ray diffraction | A, B | — | — |
| 4UJ1 | Protein Kinase A in complex with an Inhibitor | x-ray diffraction | A | — | — |
| 4UJ1 | Protein kinase a in complex with an inhibitor | x-ray diffraction | A | — | — |
| 4UJ2 | Protein Kinase A in complex with an Inhibitor | x-ray diffraction | A | — | — |
| 4UJ2 | Protein kinase a in complex with an inhibitor | x-ray diffraction | A | — | — |
| 4UJ9 | Protein Kinase A in complex with an Inhibitor | x-ray diffraction | A | — | — |
| 4UJ9 | Protein kinase a in complex with an inhibitor | x-ray diffraction | A | — | — |
| 4UJA | Protein Kinase A in complex with an Inhibitor | x-ray diffraction | A | — | — |
| 4UJA | Protein kinase a in complex with an inhibitor | x-ray diffraction | A | — | — |
| 4UJB | Protein Kinase A in complex with an Inhibitor | x-ray diffraction | A | — | — |
| 4UJB | Protein kinase a in complex with an inhibitor | x-ray diffraction | A | — | — |
| 4WB5 | Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit) | x-ray diffraction | A | — | — |
| 4WB5 | Crystal structure of human camp-dependent protein kinase a (catalytic alpha subunit) | x-ray diffraction | A | — | — |
| 4WB6 | Crystal structure of a L205R mutant of human cAMP-dependent protein kinase A (catalytic alpha… | x-ray diffraction | A, B | — | — |
| 4WB6 | Crystal structure of a L205R mutant of human camp-dependent protein kinase a (catalytic alpha… | x-ray diffraction | A, B | — | — |
| 4WB7 | Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A… | x-ray diffraction | A, B | — | — |
| 4WB7 | Crystal structure of a chimeric fusion of human dnaj (HSP40) and camp- dependent protein kinase a… | x-ray diffraction | A, B | — | — |
| 4WB8 | Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit), exon 1… | x-ray diffraction | A | — | — |
| 4WB8 | Crystal structure of human camp-dependent protein kinase a (catalytic alpha subunit), exon 1… | x-ray diffraction | A | — | — |
| 5BX6 | PKA in complex with a halogenated phthalazinone fragment compound. | x-ray diffraction | A | — | — |
| 5BX7 | PKA in complex with a benzothiophene fragment compound. | x-ray diffraction | A | — | — |
| 5IZF | Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1408 | x-ray diffraction | A | SO4 | — |
| 5IZF | Complex of PKA with the bisubstrate protein kinase inhibitor arc-1408 | x-ray diffraction | A | — | — |
19 records more on the page itself.
Ligands
- 6J9 · 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- MG · Magnesium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- 35R · 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea · in 1 record
- 504 · 2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide · in 1 record
- E3Z · ~{N}-[3-[(5-chloranyl-2-phenylazanyl-pyrimidin-4-yl) amino]phenyl]prop-2-enamide · in 1 record
- EE4 · N-[(3R,4R)-4-{[4-(2-fluoro-3-methoxy-6-propoxybenzene-1-carbonyl)benzene-1-carbonyl]amino}pyrrolidin-3-yl]-1H-indazole-5-carboxamide · in 1 record
- J4B · ~{N}'-[(2~{S})-2-[3,5-bis(fluoranyl)phenyl]-2-oxidanyl-ethanoyl]-2-ethyl-3-methyl-4-oxidanyl-benzohydrazide · in 1 record
- XTT · 6-[(6P)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7,9-dihydro-8H-purin-8-one · in 1 record
- XU0 · 6-[(6P)-6-(4-bromo-1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7H-purine · in 1 record
Experiment against prediction
- 5UZK chain A against the predicted model P17612: TM-score 1.00, RMSD 0.42 Å
- 4UJ1 chain A against the predicted model P17612: TM-score 1.00, RMSD 0.43 Å
- 4UJ1 chain A against the predicted model P17612: TM-score 1.00, RMSD 0.43 Å
- 4UJA chain A against the predicted model P17612: TM-score 1.00, RMSD 0.44 Å
- 4UJA chain A against the predicted model P17612: TM-score 1.00, RMSD 0.44 Å
- 6QJ7 chain A against the predicted model P17612: TM-score 1.00, RMSD 0.44 Å
- 3P0M chain A against the predicted model P17612: TM-score 1.00, RMSD 0.44 Å
- 3P0M chain A against the predicted model P17612: TM-score 1.00, RMSD 0.44 Å
- 4UJ2 chain A against the predicted model P17612: TM-score 1.00, RMSD 0.45 Å
- 4UJ2 chain A against the predicted model P17612: TM-score 1.00, RMSD 0.45 Å
Elsewhere
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