UniProt P17302
Gap junction alpha-1 protein (P17302)
Gap junction alpha-1 protein (UniProt P17302): 20 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 257 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P17302
- Protein
- Gap junction alpha-1 protein
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 257 · 13 records with a druggable one
Structures
21 records of P17302 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LL2 | Structure of the Cx43 C-terminal domain bound to tubulin | solution nmr | A | — | — |
| 2LL2 | Structure of the CX43 C-terminal domain bound to tubulin | solution nmr | A | — | — |
| 7F92 | Structure of connexin43/Cx43/GJA1 gap junction intercellular channel in LMNG/CHS detergents at pH… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | C14 | 20 (best 0.75) |
| 7F92 | Structure of CONNEXIN43/CX43/GJA1 gap junction intercellular channel in LMNG/CHS detergents at pH… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | C14 | — |
| 7F93 | Structure of connexin43/Cx43/GJA1 gap junction intercellular channel in nanodiscs with soybean… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | C14 | 20 (best 0.72) |
| 7F93 | Structure of CONNEXIN43/CX43/GJA1 gap junction intercellular channel in nanodiscs with soybean… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | C14 | — |
| 7F94 | Structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel with two… | electron microscopy | A, G, B, L, C, K, D, J, E, I, F, H | — | 20 (best 0.82) |
| 7F94 | Structure of C-terminal truncated CONNEXIN43/CX43/GJA1 gap junction intercellular channel with two… | electron microscopy | A, G, B, L, C, K, D, J, E, I, F, H | — | — |
| 7XQ9 | Structure of connexin43/Cx43/GJA1 gap junction intercellular channel in GDN detergents at pH ~8.0 | electron microscopy | A, G, B, C, D, E, F, H, I, J, K, L | — | 20 (best 0.72) |
| 7XQB | Structure of connexin43/Cx43/GJA1 gap junction intercellular channel in POPE/CHS nanodiscs at pH… | electron microscopy | A, G, B, C, D, E, F, H, I, J, K, L | C14, Y01, PTY | — |
| 7XQD | Structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | C14, PTY, Y01 | 20 (best 0.72) |
| 7XQF | Structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | C14, PTY, Y01 | 20 (best 0.71) |
| 7XQG | Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction… | electron microscopy | A, B, C, D, E, F | PTY, Y01 | — |
| 7XQH | Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction… | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.69) |
| 7XQI | Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction… | electron microscopy | A, B, C, D, E, F | — | 17 (best 0.74) |
| 7XQJ | Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction… | electron microscopy | A, B, C, D, E, F | — | 20 (best 0.75) |
| 7Z1T | Connexin43 gap junction channel structure in digitonin | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.76) |
| 7Z22 | Connexin43 gap junction channel structure in nanodisc | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.72) |
| 7Z23 | Connexin43 hemi channel in nanodisc | electron microscopy | E, A, B, C, D, F | — | 20 (best 0.74) |
| 8QKO | Connexin-43 gap junction channel in complex with mefloquine | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.71) |
| P17302 | AlphaFold monomer V2.0 prediction for gap junction alpha-1 protein (P17302) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7XQJ chain D against the predicted model P17302: TM-score 0.93, RMSD 1.48 Å
- 7XQJ chain F against the predicted model P17302: TM-score 0.93, RMSD 1.48 Å
- 7XQJ chain A against the predicted model P17302: TM-score 0.93, RMSD 1.48 Å
- 7XQJ chain E against the predicted model P17302: TM-score 0.93, RMSD 1.48 Å
- 7XQJ chain C against the predicted model P17302: TM-score 0.93, RMSD 1.48 Å
- 7XQJ chain B against the predicted model P17302: TM-score 0.93, RMSD 1.48 Å
- 7F94 chain E against the predicted model P17302: TM-score 0.93, RMSD 1.43 Å
- 7F94 chain E against the predicted model P17302: TM-score 0.93, RMSD 1.43 Å
- 7F94 chain F against the predicted model P17302: TM-score 0.93, RMSD 1.43 Å
- 7F94 chain F against the predicted model P17302: TM-score 0.93, RMSD 1.43 Å
Elsewhere
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