UniProt P17109
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (P17109)
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (UniProt P17109), EC 2.2.1.9: 33 experimental structures on GenesisL1, 5 ligands bound, 120 pockets. Binding sites, pockets, druggability and 3D structures…
- UniProt
- P17109
- Protein
- 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
- EC
- 2.2.1.9
- Experimental structures
- 33
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 120 · 6 records with a druggable one
Structures
33 records of P17109 in the MolNFT archive: 33 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JLA | Crystal structure of E.coli MenD, 2-succinyl-5-enolpyruvyl-6-hydroxy… | x-ray diffraction | A, B, C, D | — | — |
| 2JLA | Crystal structure of E.COLI mend, 2-succinyl-5-enolpyruvyl… | x-ray diffraction | A, B, C, D | — | — |
| 2JLC | Crystal structure of E.coli MenD, 2-succinyl-5-enolpyruvyl-6-hydroxy… | x-ray diffraction | A, B | — | — |
| 2JLC | Crystal structure of E.COLI mend, 2-succinyl-5-enolpyruvyl… | x-ray diffraction | A, B | — | — |
| 3FLM | Crystal structure of menD from E.coli | x-ray diffraction | A, B | — | — |
| 3FLM | Crystal structure of mend from E.COLI | x-ray diffraction | A, B | — | — |
| 3HWW | Crystal structure of menaqui synthesis protein MenD from E. coli in complex with oxoglutarate | x-ray diffraction | A, D | — | — |
| 3HWW | Crystal structure of menaquinone synthesis protein mend from E. COLI in complex with oxoglutarate | x-ray diffraction | A, D | — | — |
| 3HWX | Crystal structure of menaqui synthesis protein MenD from E. coli in complex with ThDP | x-ray diffraction | A, B, I, J, R, S, Z, 1 | — | — |
| 3HWX | Crystal structure of menaquinone synthesis protein mend from E. COLI in complex with thdp | x-ray diffraction | A, B, I, J, R, S, Z, 1 | — | — |
| 5EJ4 | EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 15 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MN | 20 (best 0.87) |
| 5EJ4 | Ecmend-thdp-MN2+ complex soaked with 2-ketoglutarate for 15 min | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5EJ5 | EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 1.5 h | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MN | 20 (best 0.86) |
| 5EJ5 | Ecmend-thdp-MN2+ complex soaked with 2-ketoglutarate for 1.5 H | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5EJ6 | EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2min then soaked with isochorismate for 2… | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MN | 20 (best 0.85) |
| 5EJ6 | Ecmend-thdp-MN2+ complex soaked with 2-ketoglutarate for 2MIN then soaked with isochorismate for 2… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5EJ7 | EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 21 s | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MN | — |
| 5EJ7 | Ecmend-thdp-MN2+ complex soaked with 2-ketoglutarate for 21 S | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5EJ8 | EcMenD-ThDP-Mn2+ complex structure soaked with 2-ketoglutarate for 2 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MN, MG | — |
| 5EJ8 | Ecmend-thdp-MN2+ complex structure soaked with 2-ketoglutarate for 2 min | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5EJ9 | EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min | x-ray diffraction | A, B, C, D, E, F, G, H | TPP, MN | — |
| 5EJ9 | Ecmend-thdp-MN2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5EJA | EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and soaked with isochorismate for 7… | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MN | 20 (best 0.87) |
| 5EJA | Ecmend-thdp-MN2+ complex soaked with 2-ketoglutarate for 2 min and soaked with isochorismate for 7… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5EJM | ThDP-Mn2+ complex of R413A variant of EcMenD soaked with 2-ketoglutarate for 35 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD5, MN | — |
| 5EJM | Thdp-MN2+ complex of R413A variant of ecmend soaked with 2- ketoglutarate for 35 min | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5Z2P | ThDP-Mn2+ complex of R413K variant of EcMenD soaked with 2-ketoglutarate for 5 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MN | — |
| 5Z2P | Thdp-MN2+ complex of R413K variant of ecmend soaked with 2- ketoglutarate for 5 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MN | — |
| 5Z2R | ThDP-Mn2+ complex of R395K variant of EcMenD soaked with 2-ketoglutarate for 5 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MG, TPP, MN | 20 (best 0.85) |
| 5Z2R | Thdp-MN2+ complex of R395K variant of ecmend soaked with 2- ketoglutarate for 5 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MG, TPP, MN | — |
| 5Z2U | ThDP-Mn2+ complex of R395A variant of EcMenD soaked with 2-ketoglutarate for 5 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MG, TPP | 20 (best 0.87) |
| 5Z2U | Thdp-MN2+ complex of R395A variant of ecmend soaked with 2- ketoglutarate for 5 min | x-ray diffraction | A, B, C, D, E, F, G, H | TD6, MG, TPP | — |
| P17109 | AlphaFold monomer V2.0 prediction for 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate… | — | — | — |
Ligands
- MN · Manganese (II) ion · in 12 records
- TD6 · (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid · in 12 records
- MG · Magnesium ion · in 5 records
- TPP · Thiamine diphosphate · in 5 records
- TD5 · (4~{R})-4-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-4-oxidanyl-butanoic acid · in 1 record
Elsewhere
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