UniProt P14756
Pro-elastase (P14756)
Pro-elastase (UniProt P14756), EC 3.4.24.26: 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P14756
- Protein
- Pro-elastase
- EC
- 3.4.24.26
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 15 · 2 records with a druggable one
Structures
11 records of P14756 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EZM | Three-dimensional structure of the elastase of pseudomonas aeruginosa at 1.5 ångströms resolution | x-ray diffraction | A | — | — |
| 1EZM | Three-dimensional structure of the elastase of pseudomonas aeruginosa at 1.5 ångströms resolution | x-ray diffraction | A | — | — |
| 1U4G | Elastase of Pseudomonas aeruginosa with an inhibitor | x-ray diffraction | A | — | — |
| 1U4G | Elastase of pseudomonas aeruginosa with an inhibitor | x-ray diffraction | A | — | — |
| 3DBK | Pseudomonas aeruginosa elastase with phosphoramidon | x-ray diffraction | A | — | — |
| 3DBK | Pseudomonas aeruginosa elastase with phosphoramidon | x-ray diffraction | A | — | — |
| 8CC4 | LasB bound to phosphonic acid based inhibitor | x-ray diffraction | A, B | CA, U7F, ZN | 7 (best 0.78) |
| 8CR3 | Crystal structure of recombinant LasB from Pseudomonas aeruginosa PAO1 | x-ray diffraction | A | ZN, CA | 1 (best 0.43) |
| 8CR7 | Crystal structure of recombinant LasB from Pseudomonas aeruginosa PA7 | x-ray diffraction | A, B | ZN, CA | 5 (best 0.66) |
| 8R1B | Crystal structure of recombinant LasB from Pseudomonas aeruginosa PAO1 in complex with 6466 | x-ray diffraction | A | ZN, CA, SCN, XI5 | 2 (best 0.46) |
| P14756 | AlphaFold monomer V2.0 prediction for elastase (P14756) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
- ZN · Zinc ion · in 4 records
- SCN · Thiocyanate ion · in 1 record
- U7F · [(2~{R})-4-methyl-1-oxidanylidene-1-[[4-(trifluoromethyl)phenyl]amino]pentan-2-yl]phosphonic acid · in 1 record
- XI5 · [(2~{S})-1-[[1-[(4-ethanoylphenyl)amino]-3-methyl-1-oxidanylidene-butan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]phosphonic acid · in 1 record
Experiment against prediction
- 8R1B chain A against the predicted model P14756: TM-score 0.99, RMSD 0.50 Å
- 1EZM chain A against the predicted model P14756: TM-score 0.99, RMSD 0.58 Å
- 1EZM chain A against the predicted model P14756: TM-score 0.99, RMSD 0.58 Å
- 8CR7 chain B against the predicted model P14756: TM-score 0.99, RMSD 0.63 Å
- 8CR3 chain A against the predicted model P14756: TM-score 0.99, RMSD 0.65 Å
- 8CR7 chain A against the predicted model P14756: TM-score 0.99, RMSD 0.74 Å
- 1U4G chain A against the predicted model P14756: TM-score 0.99, RMSD 0.75 Å
- 1U4G chain A against the predicted model P14756: TM-score 0.99, RMSD 0.75 Å
- 8CC4 chain A against the predicted model P14756: TM-score 0.99, RMSD 0.77 Å
- 8CC4 chain B against the predicted model P14756: TM-score 0.99, RMSD 0.78 Å
Elsewhere
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