UniProt P13995
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (P13995)
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (UniProt P13995), EC 1.5.1.15, 3.5.4.9: 23 experimental structures on GenesisL1, 16 ligands bound, 35 pockets. Binding sites, pockets…
- UniProt
- P13995
- Protein
- Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase…
- EC
- 1.5.1.15, 3.5.4.9
- Experimental structures
- 23
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 35 · 7 records with a druggable one
Structures
23 records of P13995 in the MolNFT archive: 23 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5TC4 | Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase… | x-ray diffraction | A | NAD, L34, PO4 | 2 (best 0.68) |
| 5TC4 | Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase… | x-ray diffraction | A | NAD, PO4 | — |
| 6JIB | Human MTHFD2 in complex with DS44960156 | x-ray diffraction | A, B | BQF, PO4 | — |
| 6JID | Human MTHFD2 in complex with compound 1 | x-ray diffraction | A, B | BQC, PO4 | — |
| 6KG2 | Human MTHFD2 in complex with Compound 18 | x-ray diffraction | A, B | D8C, NAD, PO4 | — |
| 6KG2 | Human MTHFD2 in complex with compound 18 | x-ray diffraction | A, B | D8C, NAD, PO4 | — |
| 6S4A | Structure of human MTHFD2 in complex with TH9028 | x-ray diffraction | A, B | KUK, PO4, NAD | — |
| 6S4A | Structure of human MTHFD2 in complex with TH9028 | x-ray diffraction | A, B | KUK, PO4, NAD | — |
| 6S4E | Structure of human MTHFD2 in complex with TH7299 | x-ray diffraction | A | 9L9, PO4, NAD | 4 (best 0.68) |
| 6S4E | Structure of human MTHFD2 in complex with TH7299 | x-ray diffraction | A | PO4, NAD | — |
| 6S4F | Structure of human MTHFD2 in complex with TH9619 | x-ray diffraction | A, B | KUN, PO4, ADP | 7 (best 0.74) |
| 6S4F | Structure of human MTHFD2 in complex with TH9619 | x-ray diffraction | A, B | KUN, PO4, ADP | — |
| 7EHJ | Human MTHFD2 in complex with compound 21, cofactor and phosphate. | x-ray diffraction | A, B | J49, NAD, PO4 | — |
| 7EHM | Human MTHFD2 in complex with compound 21 and 15 | x-ray diffraction | A, B | J49 | — |
| 7EHM | Human MTHFD2 in complex with compound 21 and 15 | x-ray diffraction | A, B | J49 | — |
| 7EHN | Human MTHFD2 in complex with compound 21 and 9 | x-ray diffraction | A, B | J4F, J49 | — |
| 7EHN | Human MTHFD2 in complex with compound 21 and 9 | x-ray diffraction | A, B | J4F, J49 | — |
| 7EHV | Human MTHFD2 in complex with compound 21 and 3 | x-ray diffraction | A, B | J4L, J49 | — |
| 9IS9 | human MTHFD2 in complex with LY374571 | x-ray diffraction | A, B | 9L9, NAD, PO4 | 5 (best 0.70) |
| 9IT3 | Human MTHFD2 in complex with compound 16e | x-ray diffraction | A, B | A1L23, NAD, PO4 | 5 (best 0.70) |
| 9IT6 | Human MTHFD2 in complex with compound 16g | x-ray diffraction | A, B | A1L24, NAD, PO4 | 6 (best 0.70) |
| 9ITA | Human MTHFD2 in complex with compound 16d | x-ray diffraction | A, B | A1L25, NAD, PO4 | 6 (best 0.70) |
| P13995 | AlphaFold monomer V2.0 prediction for bifunctional methylenetetrahydrofolate… | — | — | — |
Ligands
- PO4 · Phosphate ion · in 17 records
- NAD · Nicotinamide-adenine-dinucleotide · in 13 records
- J49 · (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl) carbamoylamino]phenyl]carbonylamino]pentanedioic acid · in 6 records
- 9L9 · (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- D8C · N-[2-chloranyl-4-[[7-methyl-8-(4-methylpiperazin-1-yl)-5-oxidanylidene-2,4-dihydro-1H-chromeno[3,4-c]pyridin-3-yl]carbonyl]phenyl]methanesulfonamide · in 2 records
- J4F · 3-[4-[[1-[(4-chloranyl-1H-indol-2-yl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]-6-methyl-pyrimidin-2-yl]propanoic acid · in 2 records
- KUK · (2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl) butanoic acid · in 2 records
- KUN · (E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid · in 2 records
- A1L23 · (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]-3-chloranyl-phenyl]carbonylamino]pentanedioic acid · in 1 record
- A1L24 · (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]-3-chloranyl-phenyl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid · in 1 record
- A1L25 · (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]-3-methyl-phenyl]carbonylamino]pentanedioic acid · in 1 record
- BQC · 5-(4-oxo-2-phenyl-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carbonyl)-1,3-dihydro-2H-2lambda~6~,1-benzothiazole-2,2-dione · in 1 record
- BQF · 4-(5-oxo-1,5-dihydro-2H-[1]benzopyrano[3,4-c]pyridine-3(4H)-carbonyl)benzoic acid · in 1 record
- J4L · 1-(3,4-dichlorobenzyl)-8-(((1R,4R)-4-hydroxycyclohexyl)amino)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione · in 1 record
- L34 · 4-(7-amino-9-hydroxy-1-oxo-3,3A,4,5-tetrahydro-2,5,6,8,9B-pentaaza-cyclopenta[a]naphthalen-2-yl)-phenylcarbonyl-glutami C acid · in 1 record
Elsewhere
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