UniProt P13864
DNA (cytosine-5)-methyltransferase 1 (P13864)
DNA (cytosine-5)-methyltransferase 1 (UniProt P13864), EC 2.1.1.37: 21 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 53 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P13864
- Protein
- DNA (cytosine-5)-methyltransferase 1
- EC
- 2.1.1.37
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 53 · 4 records with a druggable one
Structures
22 records of P13864 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3AV4 | Crystal structure of mouse DNA methyltransferase 1 | x-ray diffraction | A | — | — |
| 3AV4 | Crystal structure of mouse DNA methyltransferase 1 | x-ray diffraction | A | — | — |
| 3AV5 | Crystal structure of mouse DNA methyltransferase 1 with AdoHcy | x-ray diffraction | A | — | — |
| 3AV5 | Crystal structure of mouse DNA methyltransferase 1 with adohcy | x-ray diffraction | A | — | — |
| 3AV6 | Crystal structure of mouse DNA methyltransferase 1 with AdoMet | x-ray diffraction | A | — | — |
| 3AV6 | Crystal structure of mouse DNA methyltransferase 1 with adomet | x-ray diffraction | A | — | — |
| 3PT6 | Crystal structure of mouse DNMT1(650-1602) in complex with DNA | x-ray diffraction | A, B | — | — |
| 3PT6 | Crystal structure of mouse DNMT1(650-1602) in complex with DNA | x-ray diffraction | A, B | — | — |
| 3PT9 | Crystal structure of mouse DNMT1(731-1602) in the free state | x-ray diffraction | A | — | — |
| 3PT9 | Crystal structure of mouse DNMT1(731-1602) in the free state | x-ray diffraction | A | — | — |
| 4DA4 | Structure of mouse DNMT1 (731-1602) bound to hemimethylated CpG DNA | x-ray diffraction | A, B | — | — |
| 4DA4 | Structure of mouse DNMT1 (731-1602) bound to hemimethylated cpg DNA | x-ray diffraction | A, B | — | — |
| 5GUT | The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A | x-ray diffraction | A | SAH, ZN, SO4 | 10 (best 0.72) |
| 5GUT | The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A | x-ray diffraction | A | — | — |
| 5GUV | The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D | x-ray diffraction | A | ZN | 8 (best 0.70) |
| 5GUV | The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D | x-ray diffraction | A | — | — |
| 5WY1 | Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) | x-ray diffraction | A | ZN | 15 (best 0.74) |
| 5WY1 | Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) | x-ray diffraction | A | ZN | — |
| 6W8V | Crystal structure of mouse DNMT1 in complex with acg DNA | x-ray diffraction | A, B | ZN | — |
| 6W8W | Crystal structure of mouse DNMT1 in complex with CCG DNA | x-ray diffraction | A, B | SAH, ZN | 20 (best 0.83) |
| 6W8W | Crystal structure of mouse DNMT1 in complex with ccg DNA | x-ray diffraction | A, B | ZN | — |
| P13864 | AlphaFold monomer V2.0 prediction for DNA (cytosine-5)-methyltransferase 1 (P13864) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5GUV chain A against the predicted model P13864: TM-score 0.99, RMSD 0.88 Å
- 5GUV chain A against the predicted model P13864: TM-score 0.99, RMSD 0.88 Å
- 3PT9 chain A against the predicted model P13864: TM-score 0.99, RMSD 0.90 Å
- 3PT9 chain A against the predicted model P13864: TM-score 0.99, RMSD 0.90 Å
- 5GUT chain A against the predicted model P13864: TM-score 0.99, RMSD 1.00 Å
- 5GUT chain A against the predicted model P13864: TM-score 0.99, RMSD 1.00 Å
- 6W8W chain B against the predicted model P13864: TM-score 0.98, RMSD 1.51 Å
- 6W8W chain A against the predicted model P13864: TM-score 0.98, RMSD 1.52 Å
- 6W8W chain B against the predicted model P13864: TM-score 0.98, RMSD 1.51 Å
- 6W8W chain A against the predicted model P13864: TM-score 0.98, RMSD 1.52 Å
Elsewhere
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