UniProt P13671
Complement component C6 (P13671)
Complement component C6 (UniProt P13671): 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P13671
- Protein
- Complement component C6
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 18 · 3 records with a druggable one
Structures
15 records of P13671 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3T5O | Crystal Structure of human Complement Component C6 | x-ray diffraction | A | — | — |
| 3T5O | Crystal structure of human complement component C6 | x-ray diffraction | A | — | — |
| 4A5W | Crystal structure of C5b6 | x-ray diffraction | B | — | — |
| 4A5W | Crystal structure of C5B6 | x-ray diffraction | B | — | — |
| 4E0S | Crystal Structure of C5b-6 | x-ray diffraction | B | — | — |
| 4E0S | Crystal structure of C5B-6 | x-ray diffraction | B | — | — |
| 6H03 | Open conformation of the membrane attack complex | electron microscopy | B | NAG | — |
| 6H04 | Closed conformation of the Membrane Attack Complex | electron microscopy | B | NAG | — |
| 6H04 | Closed conformation of the membrane attack complex | electron microscopy | B | NAG | — |
| 7NYC | Cryoem structure of 3C9-smac | electron microscopy | B | FUC, NAG | — |
| 7Q6C | complement C6 FIM1-2 bound to CP010 antibody | x-ray diffraction | A | — | 3 (best 0.62) |
| 7Q6C | Complement C6 FIM1-2 bound to CP010 antibody | x-ray diffraction | A | — | — |
| 8B0G | 2C9, C5b9-CD59 structure | electron microscopy | B | NAG | 8 (best 0.86) |
| 8B0H | 2C9, C5b9-CD59 cryoEM structure | electron microscopy | B | — | 7 (best 0.85) |
| P13671 | AlphaFold monomer V2.0 prediction for complement component C6 (P13671) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7Q6C chain A against the predicted model P13671: TM-score 0.86, RMSD 2.05 Å
- 7Q6C chain A against the predicted model P13671: TM-score 0.86, RMSD 2.05 Å
- 4E0S chain B against the predicted model P13671: TM-score 0.66, RMSD 4.60 Å
- 4E0S chain B against the predicted model P13671: TM-score 0.66, RMSD 4.60 Å
- 4A5W chain B against the predicted model P13671: TM-score 0.63, RMSD 5.19 Å
- 4A5W chain B against the predicted model P13671: TM-score 0.63, RMSD 5.19 Å
- 3T5O chain A against the predicted model P13671: TM-score 0.61, RMSD 3.79 Å
- 3T5O chain A against the predicted model P13671: TM-score 0.61, RMSD 3.79 Å
- 7NYC chain B against the predicted model P13671: TM-score 0.57, RMSD 5.90 Å
- 8B0G chain B against the predicted model P13671: TM-score 0.55, RMSD 5.86 Å
Elsewhere
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