UniProt P13382
DNA polymerase alpha catalytic subunit A (P13382)
DNA polymerase alpha catalytic subunit A (UniProt P13382), EC 2.7.7.7: 17 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P13382
- Protein
- DNA polymerase alpha catalytic subunit A
- EC
- 2.7.7.7
- Experimental structures
- 17
- Predicted models
- 1
- Pockets
- 2 · 2 records with a druggable one
Structures
18 records of P13382 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3FLO | Crystal structure of the carboxyl-terminal domain of yeast DNA polymerase alpha in complex with its… | x-ray diffraction | B, D, F, H | — | — |
| 3FLO | Crystal structure of the carboxyl-terminal domain of yeast DNA polymerase alpha in complex with its… | x-ray diffraction | B, D, F, H | — | — |
| 3OIQ | Crystal structure of yeast telomere protein Cdc13 OB1 and the catalytic subunit of DNA polymerase… | x-ray diffraction | B | — | — |
| 3OIQ | Crystal structure of yeast telomere protein CDC13 OB1 and the catalytic subunit of DNA polymerase… | x-ray diffraction | B | — | — |
| 4B08 | Yeast DNA polymerase alpha, Selenomethionine protein | x-ray diffraction | A | — | — |
| 4B08 | Crystal structure of yeast DNA polymerase alpha, selenomethionine protein | x-ray diffraction | A | — | — |
| 4C93 | Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Pol alpha. | x-ray diffraction | D, E | — | — |
| 4C93 | Crystal structure of the carboxy-terminal domain of yeast CTF4 bound to pol alpha. | x-ray diffraction | D, E | — | — |
| 4FVM | Crystal structure of yeast DNA polymerase alpha | x-ray diffraction | A | — | — |
| 4FVM | Crystal structure of yeast DNA polymerase alpha | x-ray diffraction | A | — | — |
| 4FXD | Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA | x-ray diffraction | A, B | — | — |
| 4FXD | Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA | x-ray diffraction | A, B | — | — |
| 4FYD | Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTP | x-ray diffraction | A, B | — | — |
| 4FYD | Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dgtp | x-ray diffraction | A, B | — | — |
| 8B9A | S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork DNA… | electron microscopy | J | — | 1 (best 0.79) |
| 8B9B | S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate… | electron microscopy | J | — | — |
| 8B9C | S. cerevisiae pol alpha - replisome complex | electron microscopy | J | — | 1 (best 0.78) |
| P13382 | AlphaFold monomer V2.0 prediction for DNA polymerase alpha catalytic subunit a (P13382) | predicted | A | — | — |
Experiment against prediction
- 4FYD chain A against the predicted model P13382: TM-score 0.98, RMSD 1.56 Å
- 4FYD chain A against the predicted model P13382: TM-score 0.98, RMSD 1.56 Å
- 4FYD chain B against the predicted model P13382: TM-score 0.98, RMSD 1.61 Å
- 4FYD chain B against the predicted model P13382: TM-score 0.98, RMSD 1.61 Å
- 3FLO chain H against the predicted model P13382: TM-score 0.98, RMSD 0.80 Å
- 3FLO chain H against the predicted model P13382: TM-score 0.98, RMSD 0.80 Å
- 3FLO chain D against the predicted model P13382: TM-score 0.98, RMSD 0.81 Å
- 3FLO chain D against the predicted model P13382: TM-score 0.98, RMSD 0.81 Å
- 3FLO chain F against the predicted model P13382: TM-score 0.97, RMSD 0.83 Å
- 3FLO chain F against the predicted model P13382: TM-score 0.97, RMSD 0.83 Å
Elsewhere
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