UniProt P11652
Methylmalonyl-CoA mutase (P11652)
Methylmalonyl-CoA mutase (UniProt P11652), EC 5.4.99.2: 16 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 106 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P11652
- Protein
- Methylmalonyl-CoA mutase
- EC
- 5.4.99.2
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 106 · 8 records with a druggable one
Structures
17 records of P11652 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E1C | METHYLMALONYL-COA MUTASE H244A Mutant | x-ray diffraction | B, D | DCA | 17 (best 0.90) |
| 1E1C | Methylmalonyl-CoA mutase H244A mutant | x-ray diffraction | B, D | — | — |
| 1REQ | Methylmalonyl-CoA mutase | x-ray diffraction | B, D | DCA | 15 (best 0.90) |
| 1REQ | Methylmalonyl-CoA mutase | x-ray diffraction | B, D | — | — |
| 2REQ | Methylmalonyl-CoA mutase, non-productive CoA complex, in open conformation representing… | x-ray diffraction | B, D | COA | 11 (best 0.86) |
| 2REQ | Methylmalonyl-CoA mutase, non-productive CoA complex, in open conformation representing… | x-ray diffraction | B, D | — | — |
| 3REQ | Methylmalonyl-CoA mutase, substrate-free state (poor quality structure) | x-ray diffraction | B | — | 11 (best 0.86) |
| 3REQ | Methylmalonyl-CoA mutase, substrate-free state (poor quality structure) | x-ray diffraction | B | — | — |
| 4REQ | Methylmalonyl-COA Mutase substrate complex | x-ray diffraction | B, D | — | — |
| 4REQ | Methylmalonyl-CoA mutase substrate complex | x-ray diffraction | B, D | — | — |
| 5REQ | Methylmalonyl-COA MUTASE, Y89F Mutant, substrate complex | x-ray diffraction | B, D | SCD, MCD | 17 (best 0.90) |
| 5REQ | Methylmalonyl-CoA mutase, Y89F mutant, substrate complex | x-ray diffraction | B, D | SCD, MCD | — |
| 6REQ | Methylmalonyl-CoA mutase, 3-carboxypropyl-CoA inhibitor complex | x-ray diffraction | B, D | 3CP | 14 (best 0.90) |
| 6REQ | Methylmalonyl-CoA mutase, 3-carboxypropyl-CoA inhibitor complex | x-ray diffraction | B, D | 3CP | — |
| 7REQ | Methylmalonyl-CoA mutase, 2-carboxypropyl-CoA inhibitor complex | x-ray diffraction | B, D | 2CP | 15 (best 0.90) |
| 7REQ | Methylmalonyl-CoA mutase, 2-carboxypropyl-CoA inhibitor complex | x-ray diffraction | B, D | 2CP | — |
| P11652 | AlphaFold monomer V2.0 prediction for methylmalonyl-CoA mutase small subunit (P11652) | predicted | A | — | 6 (best 0.61) |
Ligands
Experiment against prediction
- 1REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.25 Å
- 1REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.25 Å
- 6REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.26 Å
- 6REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.26 Å
- 4REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.28 Å
- 4REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.28 Å
- 5REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.29 Å
- 5REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.29 Å
- 5REQ chain D against the predicted model P11652: TM-score 1.00, RMSD 0.30 Å
- 7REQ chain B against the predicted model P11652: TM-score 1.00, RMSD 0.31 Å
Elsewhere
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