UniProt P10253
Lysosomal alpha-glucosidase (P10253)
Lysosomal alpha-glucosidase (UniProt P10253), EC 3.2.1.20: 15 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P10253
- Protein
- Lysosomal alpha-glucosidase
- EC
- 3.2.1.20
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 44 · 4 records with a druggable one
Structures
16 records of P10253 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5KZW | Crystal structure of human GAA | x-ray diffraction | A | NAG, FCA, GLC, BGC, SO4 | — |
| 5KZW | Crystal structure of human gaa | x-ray diffraction | A | NAG, FCA, GLC, BGC, SO4 | — |
| 5KZX | Crystal structure of human GAA | x-ray diffraction | A | NAG, FCA, GLC, BGC, SO4 | — |
| 5KZX | Crystal structure of human gaa | x-ray diffraction | A | NAG, FCA, GLC, BGC, SO4 | — |
| 5NN3 | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA | x-ray diffraction | A | NAG, SO4, CL | — |
| 5NN3 | Crystal structure of human lysosomal acid-alpha-glucosidase, gaa | x-ray diffraction | A | NAG, SO4, CL | — |
| 5NN4 | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-acetyl-cysteine | x-ray diffraction | A | NAG, FUC, SC2, SO4, CL | 11 (best 0.57) |
| 5NN4 | Crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with N-acetyl-cysteine | x-ray diffraction | A | NAG, FUC, SO4, CL | — |
| 5NN5 | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with 1-deoxynojirimycin | x-ray diffraction | A | NAG, FUC, NOJ, SO4, CL | 11 (best 0.58) |
| 5NN5 | Crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with 1-deoxynojirimycin | x-ray diffraction | A | NAG, FUC, NOJ, SO4, CL | — |
| 5NN6 | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with… | x-ray diffraction | A | NAG, FUC, MIG, SO4, CL | — |
| 5NN6 | Crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with… | x-ray diffraction | A | NAG, FUC, MIG, SO4, CL | — |
| 5NN8 | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with acarbose | x-ray diffraction | A | NAG, FUC, GLC, AC1, SO4, CL | 11 (best 0.55) |
| 5NN8 | Crystal structure of human lysosomal acid-alpha-glucosidase, gaa, in complex with acarbose | x-ray diffraction | A | NAG, FUC, GLC, AC1, SO4, CL | — |
| 7P2Z | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with cyclosulfamidate 4 | x-ray diffraction | AAA, AaA | NAG, FUC, SO4, CL, YTW | 11 (best 0.58) |
| P10253 | AlphaFold monomer V2.0 prediction for lysosomal alpha-glucosidase (P10253) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 15 records
- SO4 · Sulfate ion · in 15 records
- CL · Chloride ion · in 11 records
- FUC · alpha-L-fucopyranose · in 9 records
- GLC · alpha-D-glucopyranose · in 6 records
- BGC · beta-D-glucopyranose · in 4 records
- FCA · alpha-D-fucopyranose · in 4 records
- AC1 · 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose · in 2 records
- MIG · (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl) piperidine-3,4,5-triol · in 2 records
- NOJ · 1-deoxynojirimycin · in 2 records
- SC2 · N-acetyl-L-cysteine · in 1 record
- YTW · (3~{A}~{R},4~{S},5~{S},6~{S},7~{R},7~{A}~{S})-7-(hydroxymethyl)-2,2-bis(oxidanylidene)-3~{A},4,5,6,7, 7~{A}-hexahydro-3~{H}-benzo[d][1,2,3]oxathiazole-4,5, 6-triol · in 1 record
Experiment against prediction
- 5KZW chain A against the predicted model P10253: TM-score 1.00, RMSD 0.27 Å
- 5KZX chain A against the predicted model P10253: TM-score 1.00, RMSD 0.27 Å
- 5KZW chain A against the predicted model P10253: TM-score 1.00, RMSD 0.27 Å
- 5KZX chain A against the predicted model P10253: TM-score 1.00, RMSD 0.27 Å
- 5NN3 chain A against the predicted model P10253: TM-score 1.00, RMSD 0.34 Å
- 5NN3 chain A against the predicted model P10253: TM-score 1.00, RMSD 0.34 Å
- 5NN6 chain A against the predicted model P10253: TM-score 1.00, RMSD 0.51 Å
- 5NN6 chain A against the predicted model P10253: TM-score 1.00, RMSD 0.51 Å
- 5NN4 chain A against the predicted model P10253: TM-score 1.00, RMSD 0.52 Å
- 5NN8 chain A against the predicted model P10253: TM-score 1.00, RMSD 0.54 Å
Elsewhere
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