UniProt P0CX49
60S ribosomal protein L18-A (P0CX49)
60S ribosomal protein L18-A (UniProt P0CX49): 166 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 172 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0CX49
- Protein
- 60S ribosomal protein L18-A
- Experimental structures
- 166
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 172 · 87 records with a druggable one
Structures
167 records of P0CX49 in the MolNFT archive: 166 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J6X | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II) | electron microscopy | 58 | — | — |
| 3J6Y | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I) | electron microscopy | 58 | — | — |
| 3J77 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | 68 | — | — |
| 3J78 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | 68 | — | — |
| 3JCT | Cryo-em structure of eukaryotic pre-60S ribosomal subunits | electron microscopy | Q | — | — |
| 4U3M | Crystal structure of Anisomycin bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U3N | Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U3U | Crystal structure of Cycloheximide bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U4N | Crystal structure of Edeine bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U4O | Crystal structure of Geneticin bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U4Q | Crystal structure of Homoharringtonine bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U4R | Crystal structure of Lactimidomycin bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U4U | Crystal structure of Lycorine bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U4Y | Crystal structure of Pactamycin bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U4Z | Crystal structure of Phyllanthoside bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U50 | Crystal structure of Verrucarin bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U51 | Crystal structure of Narciclasine bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U52 | Crystal structure of Nagilactone C bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U53 | Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U55 | Crystal structure of Cryptopleurine bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U56 | Crystal structure of Blasticidin S bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4U6F | Crystal structure of T-2 toxin bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | — | — |
| 4V7F | Arx1 pre-60S particle. | electron microscopy | Q | — | — |
| 4V7F | ARX1 pre-60S particle. | electron microscopy | Q | — | — |
| 4V88 | The structure of the eukaryotic ribosome at 3.0 A resolution. | x-ray diffraction | BQ, DQ | — | — |
| 4V8T | Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1 | electron microscopy | Q | — | — |
| 4V8Y | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | electron microscopy | BQ | — | — |
| 4V8Z | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | electron microscopy | BQ | — | — |
| 5DGF | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA… | x-ray diffraction | M8, m8 | — | 4 (best 0.88) |
| 5DGV | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA… | x-ray diffraction | M8, m8 | — | 2 (best 0.88) |
| 5FCI | Structure of the vacant uL3 W255C mutant 80S yeast ribosome | x-ray diffraction | M8, m8 | OHX, MG | 3 (best 0.87) |
| 5GAK | Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A | electron microscopy | S | — | 3 (best 0.87) |
| 5H4P | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1 | electron microscopy | Q | — | — |
| 5I4L | Crystal structure of Amicoumacin A bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | OHX, MG | 4 (best 0.87) |
| 5JCS | Cryo-EM structure of the RIX1-REA1 pre-60S particle | electron microscopy | Q | — | — |
| 5JUO | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | V | — | 3 (best 0.88) |
| 5JUP | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | V | — | — |
| 5JUS | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | V | — | — |
| 5JUT | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | V | — | 3 (best 0.88) |
| 5JUU | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | V | — | 2 (best 0.88) |
| 5LYB | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | M8, m8 | MG, OHX | 5 (best 0.87) |
| 5M1J | Nonstop ribosomal complex bound with Dom34 and Hbs1 | electron microscopy | Q5 | MG | — |
| 5MC6 | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | electron microscopy | BB | — | — |
| 5MEI | Crystal structure of Agelastatin A bound to the 80S ribosome | x-ray diffraction | y, CS | OHX, MG | — |
| 5NDG | Crystal structure of geneticin (G418) bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | MG | 1 (best 0.88) |
| 5NDV | Crystal structure of Paromomycin bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | PAR, MG | 4 (best 0.89) |
| 5NDW | Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome | x-ray diffraction | m8, M8 | MG | 1 (best 0.88) |
| 5OBM | Crystal structure of Gentamicin bound to the yeast 80S ribosome | x-ray diffraction | M8, m8 | MG | 1 (best 0.88) |
| 5T62 | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | d | — | 2 (best 0.88) |
| 5T6R | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | d | — | 3 (best 0.87) |
| 5TGA | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | M8, m8 | OHX, MG | 3 (best 0.87) |
| 5TGM | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | M8, m8 | OHX, MG | 5 (best 0.89) |
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP) | electron microscopy | U | — | 1 (best 0.83) |
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (RPF1-tap) | electron microscopy | U | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | Q | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | Q | — | — |
| 6ELZ | State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | electron microscopy | Q | — | — |
| 6EM3 | State A architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | Q | — | 1 (best 0.66) |
| 6EM3 | State a architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | Q | — | — |
| 6EM4 | State B architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | Q | — | — |
107 records more on the page itself.
Ligands
Experiment against prediction
- 8E5T chain Q against the predicted model P0CX49: TM-score 0.99, RMSD 0.50 Å
- 7NAC chain Q against the predicted model P0CX49: TM-score 0.99, RMSD 0.51 Å
- 7R7A chain Q against the predicted model P0CX49: TM-score 0.99, RMSD 0.53 Å
- 7OH3 chain Q against the predicted model P0CX49: TM-score 0.99, RMSD 0.53 Å
- 7OHQ chain Q against the predicted model P0CX49: TM-score 0.98, RMSD 0.56 Å
- 7OHR chain Q against the predicted model P0CX49: TM-score 0.98, RMSD 0.54 Å
- 6EM3 chain Q against the predicted model P0CX49: TM-score 0.98, RMSD 0.57 Å
- 6EM3 chain Q against the predicted model P0CX49: TM-score 0.98, RMSD 0.57 Å
- 6EM4 chain Q against the predicted model P0CX49: TM-score 0.98, RMSD 0.57 Å
- 6C0F chain Q against the predicted model P0CX49: TM-score 0.98, RMSD 0.58 Å
Elsewhere
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