UniProt P0CX25
60S ribosomal protein L43-A (P0CX25)
60S ribosomal protein L43-A (UniProt P0CX25): 173 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0CX25
- Protein
- 60S ribosomal protein L43-A
- Experimental structures
- 173
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 52 · 48 records with a druggable one
Structures
174 records of P0CX25 in the MolNFT archive: 173 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J6X | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II) | electron microscopy | 83 | — | — |
| 3J6Y | S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I) | electron microscopy | 83 | — | — |
| 3J77 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | 93 | — | — |
| 3J78 | Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class… | electron microscopy | 93 | — | — |
| 3JCT | Cryo-em structure of eukaryotic pre-60S ribosomal subunits | electron microscopy | p | — | — |
| 4U3M | Crystal structure of Anisomycin bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U3N | Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U3U | Crystal structure of Cycloheximide bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U4N | Crystal structure of Edeine bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U4O | Crystal structure of Geneticin bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U4Q | Crystal structure of Homoharringtonine bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U4R | Crystal structure of Lactimidomycin bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U4U | Crystal structure of Lycorine bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U4Y | Crystal structure of Pactamycin bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U4Z | Crystal structure of Phyllanthoside bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U50 | Crystal structure of Verrucarin bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U51 | Crystal structure of Narciclasine bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U52 | Crystal structure of Nagilactone C bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U53 | Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U55 | Crystal structure of Cryptopleurine bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U56 | Crystal structure of Blasticidin S bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4U6F | Crystal structure of T-2 toxin bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | — | — |
| 4V7F | Arx1 pre-60S particle. | electron microscopy | k | — | — |
| 4V7F | ARX1 pre-60S particle. | electron microscopy | k | — | — |
| 4V88 | The structure of the eukaryotic ribosome at 3.0 A resolution. | x-ray diffraction | Dp | — | — |
| 4V8T | Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1 | electron microscopy | p | — | — |
| 5DGF | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA… | x-ray diffraction | Q3, q3 | ZN | — |
| 5DGV | Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA… | x-ray diffraction | Q3, q3 | ZN | — |
| 5FCI | Structure of the vacant uL3 W255C mutant 80S yeast ribosome | x-ray diffraction | Q3, q3 | ZN, OHX | — |
| 5GAK | Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A | electron microscopy | D | — | 1 (best 0.87) |
| 5H4P | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1 | electron microscopy | p | — | — |
| 5I4L | Crystal structure of Amicoumacin A bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | ZN | — |
| 5JCS | Cryo-EM structure of the RIX1-REA1 pre-60S particle | electron microscopy | p | — | — |
| 5JUO | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | UA | — | 1 (best 0.89) |
| 5JUP | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | UA | — | — |
| 5JUS | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | UA | — | — |
| 5JUT | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | UA | — | 1 (best 0.88) |
| 5JUU | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | UA | — | — |
| 5LYB | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | Q3, q3 | MG, ZN, OHX | — |
| 5MC6 | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | electron microscopy | AT | — | — |
| 5MEI | Crystal structure of Agelastatin A bound to the 80S ribosome | x-ray diffraction | AQ, DR | ZN, MG | — |
| 5NDG | Crystal structure of geneticin (G418) bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | ZN | 1 (best 0.88) |
| 5NDV | Crystal structure of Paromomycin bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | MG, ZN | — |
| 5NDW | Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome | x-ray diffraction | q3, Q3 | MG, ZN | 1 (best 0.89) |
| 5OBM | Crystal structure of Gentamicin bound to the yeast 80S ribosome | x-ray diffraction | Q3, q3 | MG, ZN | 1 (best 0.88) |
| 5T62 | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | R | — | — |
| 5T6R | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | R | — | 1 (best 0.85) |
| 5TGA | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | Q3, q3 | MG, ZN | — |
| 5TGM | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA… | x-ray diffraction | Q3, q3 | ZN | — |
| 6FT6 | Structure of the Nop53 pre-60S particle bound to the exosome nuclear cofactors | electron microscopy | p | ZN | 1 (best 0.86) |
| 6GQ1 | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin) | electron microscopy | p | ZN | — |
| 6GQB | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) | electron microscopy | p | ZN | — |
| 6GQV | Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) | electron microscopy | p | ZN | — |
| 6HD7 | Cryo-EM structure of the ribosome-NatA complex | electron microscopy | D | — | — |
| 6HHQ | Crystal structure of compound C45 bound to the yeast 80S ribosome | x-ray diffraction | AQ, DR | ZN, MG | — |
| 6I7O | The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways… | electron microscopy | AT, XT | ZN | — |
| 6M62 | Cryo-Em structure of eukaryotic pre-60S ribosome subunit from Saccharomyces cerevisiae rpf2 delta… | electron microscopy | p | ZN | — |
| 6N8J | Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit | electron microscopy | p | — | — |
| 6N8K | Cryo-EM structure of early cytoplasmic-immediate (ECI) pre-60S ribosomal subunit | electron microscopy | p | — | — |
| 6N8L | Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit | electron microscopy | p | — | — |
114 records more on the page itself.
Ligands
Experiment against prediction
- 8CGN chain b against the predicted model P0CX25: TM-score 0.99, RMSD 0.41 Å
- 8EWB chain Ap against the predicted model P0CX25: TM-score 0.99, RMSD 0.42 Å
- 7UQB chain p against the predicted model P0CX25: TM-score 0.99, RMSD 0.42 Å
- 7V08 chain p against the predicted model P0CX25: TM-score 0.99, RMSD 0.42 Å
- 7UOO chain p against the predicted model P0CX25: TM-score 0.99, RMSD 0.43 Å
- 6TB3 chain AT against the predicted model P0CX25: TM-score 0.99, RMSD 0.45 Å
- 6SNT chain aa against the predicted model P0CX25: TM-score 0.98, RMSD 0.44 Å
- 8UT0 chain Lr against the predicted model P0CX25: TM-score 0.98, RMSD 0.44 Å
- 8EVP chain Ap against the predicted model P0CX25: TM-score 0.98, RMSD 0.45 Å
- 7UQZ chain p against the predicted model P0CX25: TM-score 0.98, RMSD 0.45 Å
Elsewhere
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