UniProt P0AEW6
Inosine-guanosine kinase (P0AEW6)
Inosine-guanosine kinase (UniProt P0AEW6), EC 2.7.1.73: 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AEW6
- Protein
- Inosine-guanosine kinase
- EC
- 2.7.1.73
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 9 · 2 records with a druggable one
Structures
5 records of P0AEW6 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6VWO | Crystal structure of E. coli guanosine kinase | x-ray diffraction | A | ADP, GMP, K, MG | 3 (best 0.76) |
| 6VWO | Crystal structure of E. COLI guanosine kinase | x-ray diffraction | A | ADP, GMP, K | — |
| 6VWP | Crystal structure of E. coli guanosine kinase in complex with ppGpp | x-ray diffraction | A, B, C, D, E, F, G, H | G4P, GMP, K, MG | — |
| 6VWP | Crystal structure of E. COLI guanosine kinase in complex with ppgpp | x-ray diffraction | A, B, C, D, E, F, G, H | G4P, GMP, K, MG | — |
| P0AEW6 | AlphaFold monomer V2.0 prediction for inosine-guanosine kinase (P0AEW6) | predicted | A | — | 6 (best 0.71) |
Ligands
Experiment against prediction
- 6VWO chain A against the predicted model P0AEW6: TM-score 0.93, RMSD 2.32 Å
- 6VWO chain A against the predicted model P0AEW6: TM-score 0.93, RMSD 2.32 Å
- 6VWP chain H against the predicted model P0AEW6: TM-score 0.90, RMSD 2.32 Å
- 6VWP chain H against the predicted model P0AEW6: TM-score 0.90, RMSD 2.32 Å
- 6VWP chain F against the predicted model P0AEW6: TM-score 0.89, RMSD 2.60 Å
- 6VWP chain F against the predicted model P0AEW6: TM-score 0.89, RMSD 2.60 Å
- 6VWP chain E against the predicted model P0AEW6: TM-score 0.88, RMSD 2.80 Å
- 6VWP chain E against the predicted model P0AEW6: TM-score 0.88, RMSD 2.80 Å
- 6VWP chain B against the predicted model P0AEW6: TM-score 0.88, RMSD 2.77 Å
- 6VWP chain B against the predicted model P0AEW6: TM-score 0.88, RMSD 2.77 Å
Elsewhere
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