UniProt P0AEE3
Serine endoprotease DegS (P0AEE3)
Serine endoprotease DegS (UniProt P0AEE3), EC 3.4.21.107: 42 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AEE3
- Protein
- Serine endoprotease DegS
- EC
- 3.4.21.107
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 1 record with a druggable one
Structures
43 records of P0AEE3 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QF0 | Structure of the delta PDZ truncation of the DegS protease | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 2QF0 | Structure of the delta PDZ truncation of the degs protease | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 2QF3 | Structure of the delta PDZ truncation of the DegS protease | x-ray diffraction | A, B, C | — | — |
| 2QF3 | Structure of the delta PDZ truncation of the degs protease | x-ray diffraction | A, B, C | — | — |
| 2QGR | Structure of the R178A mutant of delta PDZ DegS protease | x-ray diffraction | A | — | — |
| 2QGR | Structure of the R178A mutant of delta PDZ degs protease | x-ray diffraction | A | — | — |
| 2R3U | Crystal structure of the PDZ deletion mutant of DegS | x-ray diffraction | A, B, C | — | — |
| 2R3U | Crystal structure of the PDZ deletion mutant of degs | x-ray diffraction | A, B, C | — | — |
| 2R3Y | Crystal structure of the DegS protease in complex with the YWF activating peptide | x-ray diffraction | A, B, C | — | — |
| 2R3Y | Crystal structure of the degs protease in complex with the ywf activating peptide | x-ray diffraction | A, B, C | — | — |
| 2RCE | DFP modified DegS delta PDZ | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 2RCE | Dfp modified degs delta PDZ | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 3B8J | Q191A mutant of DegS-deltaPDZ | x-ray diffraction | A | — | — |
| 3B8J | Q191A mutant of degs-deltapdz | x-ray diffraction | A | — | — |
| 3GCN | Crystal structure of DegS H198P/D320A mutant modified by DFP in complex with OMP peptide (YQF) | x-ray diffraction | A | — | — |
| 3GCN | Crystal structure of degs H198P/D320A mutant modified by dfp in complex with omp peptide (yqf) | x-ray diffraction | A | — | — |
| 3GCO | Crystal structure of DegS H198P/D320A mutant modified by DFP in complex with DNRDGNVYQF OMP peptide | x-ray diffraction | A | — | — |
| 3GCO | Crystal structure of degs H198P/D320A mutant modified by dfp in complex with dnrdgnvyqf omp peptide | x-ray diffraction | A | — | — |
| 3GDS | Crystal structure of DegS H198P/D320A mutant modified by DFP in complex with DNRDGNVYYF peptide | x-ray diffraction | A | — | — |
| 3GDS | Crystal structure of degs H198P/D320A mutant modified by dfp in complex with dnrdgnvyyf peptide | x-ray diffraction | A | — | — |
| 3GDU | Crystal structure of DegS H198P/D320A mutant modified by DFP and in complex with YRF peptide | x-ray diffraction | A, B, C | — | — |
| 3GDU | Crystal structure of degs H198P/D320A mutant modified by dfp and in complex with yrf peptide | x-ray diffraction | A, B, C | — | — |
| 3GDV | Crystal structure of DegS H198P/D320A mutant modified by DFP and in complex with YQF peptide | x-ray diffraction | A, B, C | — | — |
| 3GDV | Crystal structure of degs H198P/D320A mutant modified by dfp and in complex with yqf peptide | x-ray diffraction | A, B, C | — | — |
| 3LGI | Structure of the protease domain of DegS (DegS-deltaPDZ) at 1.65 A | x-ray diffraction | A, B, C | — | — |
| 3LGI | Structure of the protease domain of degs (degs-deltapdz) at 1.65 a | x-ray diffraction | A, B, C | — | — |
| 3LGT | Y162A/H198P double mutant of DegS-deltaPDZ protease | x-ray diffraction | A | — | — |
| 3LGT | Y162A/H198P double mutant of degs-deltapdz protease | x-ray diffraction | A | — | — |
| 3LGU | Y162A mutant of the DegS-deltaPDZ protease | x-ray diffraction | A | — | — |
| 3LGU | Y162A mutant of the degs-deltapdz protease | x-ray diffraction | A | — | — |
| 3LGV | H198P mutant of the DegS-deltaPDZ protease | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 3LGV | H198P mutant of the degs-deltapdz protease | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 3LGW | H198P/T167V double mutant of DegS-deltaPDZ protease | x-ray diffraction | A | — | — |
| 3LGW | H198P/T167V double mutant of degs-deltapdz protease | x-ray diffraction | A | — | — |
| 3LGY | R178A mutant of the DegS-deltaPDZ protease | x-ray diffraction | A | — | — |
| 3LGY | R178A mutant of the degs-deltapdz protease | x-ray diffraction | A | — | — |
| 3LH1 | Q191A mutant of the DegS-deltaPDZ | x-ray diffraction | A | — | — |
| 3LH1 | Q191A mutant of the degs-deltapdz | x-ray diffraction | A | — | — |
| 3LH3 | DFP modified DegS delta PDZ | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 3LH3 | Dfp modified degs delta PDZ | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 6EW9 | Crystal structure of degs stress sensor protease in complex with activating dnrlglvyqf peptide | x-ray diffraction | A, B, C | CA | 10 (best 0.60) |
| 6EW9 | Crystal structure of degs stress sensor protease in complex with activating dnrlglvyqf peptide | x-ray diffraction | A, B, C | CA | — |
| P0AEE3 | AlphaFold monomer V2.0 prediction for serine endoprotease degs (P0AEE3) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 2 records
Experiment against prediction
- 2QF3 chain A against the predicted model P0AEE3: TM-score 0.99, RMSD 0.61 Å
- 2QF3 chain A against the predicted model P0AEE3: TM-score 0.99, RMSD 0.61 Å
- 3LGV chain D against the predicted model P0AEE3: TM-score 0.99, RMSD 0.69 Å
- 3LGV chain D against the predicted model P0AEE3: TM-score 0.99, RMSD 0.69 Å
- 3LH3 chain I against the predicted model P0AEE3: TM-score 0.98, RMSD 0.77 Å
- 3LH3 chain I against the predicted model P0AEE3: TM-score 0.98, RMSD 0.77 Å
- 2RCE chain I against the predicted model P0AEE3: TM-score 0.98, RMSD 0.77 Å
- 2RCE chain I against the predicted model P0AEE3: TM-score 0.98, RMSD 0.77 Å
- 2QF0 chain D against the predicted model P0AEE3: TM-score 0.98, RMSD 0.83 Å
- 2QF0 chain D against the predicted model P0AEE3: TM-score 0.98, RMSD 0.83 Å
Elsewhere
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