UniProt P0AD64
Beta-lactamase SHV-1 (P0AD64)
Beta-lactamase SHV-1 (UniProt P0AD64), EC 3.5.2.6: 62 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AD64
- Protein
- Beta-lactamase SHV-1
- EC
- 3.5.2.6
- Experimental structures
- 62
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 2 · 1 record with a druggable one
Structures
63 records of P0AD64 in the MolNFT archive: 62 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G2U | Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex | x-ray diffraction | A | — | — |
| 2G2U | Crystal structure of the shv-1 beta-LACTAMASE/BETA-lactamase inhibitor protein (blip) complex | x-ray diffraction | A | — | — |
| 2G2W | Crystal Structure of the SHV D104K Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex | x-ray diffraction | A | — | — |
| 2G2W | Crystal structure of the shv D104K beta-LACTAMASE/BETA-lactamase inhibitor protein (blip) complex | x-ray diffraction | A | — | — |
| 2H0Y | Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to sulbactam | x-ray diffraction | A | — | — |
| 2H0Y | Crystal structure of the M69V E166A double mutant of shv-1 B-lactamase complexed to sulbactam | x-ray diffraction | A | — | — |
| 2H10 | Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to tazobactam | x-ray diffraction | A | — | — |
| 2H10 | Crystal structure of the M69V E166A double mutant of shv-1 B-lactamase complexed to tazobactam | x-ray diffraction | A | — | — |
| 2ZD8 | SHV-1 class A beta-lactamase complexed with meropenem | x-ray diffraction | A | — | — |
| 2ZD8 | Shv-1 class a beta-lactamase complexed with meropenem | x-ray diffraction | A | — | — |
| 3C4O | Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP)… | x-ray diffraction | A | — | — |
| 3C4O | Crystal structure of the shv-1 beta-LACTAMASE/BETA-lactamase inhibitor protein (blip)… | x-ray diffraction | A | — | — |
| 3C4P | Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M complex | x-ray diffraction | A | — | — |
| 3C4P | Crystal structure of the shv-1 beta-LACTAMASE/BETA-lactamase inhibitor protein (blip) E73M complex | x-ray diffraction | A | — | — |
| 3D4F | SHV-1 beta-lactamase complex with LN1-255 | x-ray diffraction | A | — | — |
| 3D4F | Shv-1 beta-lactamase complex with LN1-255 | x-ray diffraction | A | — | — |
| 3MKE | SHV-1 beta-lactamase complex with LP06 | x-ray diffraction | A | — | — |
| 3MKE | Shv-1 beta-lactamase complex with LP06 | x-ray diffraction | A | — | — |
| 3MKF | SHV-1 beta-lactamase complex with GB0301 | x-ray diffraction | A | — | — |
| 3MKF | Shv-1 beta-lactamase complex with GB0301 | x-ray diffraction | A | — | — |
| 3MXR | SHV-1 beta-lactamase complex with compound 1 | x-ray diffraction | A | — | — |
| 3MXR | Shv-1 beta-lactamase complex with compound 1 | x-ray diffraction | A | — | — |
| 3MXS | SHV-1 beta-lactamase complex with compound 2 | x-ray diffraction | A | — | — |
| 3MXS | Shv-1 beta-lactamase complex with compound 2 | x-ray diffraction | A | — | — |
| 3N4I | Crystal structure of the SHV-1 D104E beta-lactamase/beta-lactamase inhibitor protein (BLIP) complex | x-ray diffraction | A | — | — |
| 3N4I | Crystal structure of the shv-1 D104E beta-LACTAMASE/BETA-lactamase inhibitor protein (blip) complex | x-ray diffraction | A | — | — |
| 3OPH | ESBL R164S mutant of SHV-1 beta-lactamase | x-ray diffraction | A | — | — |
| 3OPH | Esbl R164S mutant of shv-1 beta-lactamase | x-ray diffraction | A | — | — |
| 3OPL | ESBL R164H mutant SHV-1 beta-lactamase | x-ray diffraction | A | — | — |
| 3OPL | Esbl R164H mutant shv-1 beta-lactamase | x-ray diffraction | A | — | — |
| 3OPP | ESBL R164S mutant of SHV-1 beta-lactamase complexed with SA2-13 | x-ray diffraction | A | — | — |
| 3OPP | Esbl R164S mutant of shv-1 beta-lactamase complexed with SA2-13 | x-ray diffraction | A | — | — |
| 3OPR | ESBL R164H mutant of SHV-1 beta-lactamase complexed to SA2-13 | x-ray diffraction | A | — | — |
| 3OPR | Esbl R164H mutant of shv-1 beta-lactamase complexed to SA2-13 | x-ray diffraction | A | — | — |
| 4FCF | K234R: apo structure of inhibitor resistant beta-lactamase | x-ray diffraction | A | — | — |
| 4FCF | K234R: apo structure of inhibitor resistant beta-lactamase | x-ray diffraction | A | — | — |
| 4FD8 | Structure of apo S70C SHV beta-lactamase | x-ray diffraction | A | — | — |
| 4FD8 | Structure of apo S70C shv beta-lactamase | x-ray diffraction | A | — | — |
| 4FH2 | Structure of s70c beta-lactamase bound to sulbactam | x-ray diffraction | A | — | — |
| 4FH2 | Structure of S70C beta-lactamase bound to sulbactam | x-ray diffraction | A | — | — |
| 4FH4 | high-resolution structure of apo wt SHV-1 beta-lactamase | x-ray diffraction | A | — | — |
| 4FH4 | High-resolution structure of apo wt shv-1 beta-lactamase | x-ray diffraction | A | — | — |
| 4GD6 | SHV-1 beta-lactamase in complex with penam sulfone SA1-204 | x-ray diffraction | A | — | — |
| 4GD6 | Shv-1 beta-lactamase in complex with penam sulfone SA1-204 | x-ray diffraction | A | — | — |
| 4GD8 | SHV-1 beta-lactamase in complex with penam sulfone SA3-53 | x-ray diffraction | A | — | — |
| 4GD8 | Shv-1 beta-lactamase in complex with penam sulfone SA3-53 | x-ray diffraction | A | — | — |
| 4GDB | SHV-1 in complex with 4H-pyrazolo[1,5-c][1,3]thiazole containing penem inhibitor | x-ray diffraction | A | — | — |
| 4GDB | Shv-1 in complex with 4H-PYRAZOLO[1,5-C][1,3]THIAZOLE containing penem inhibitor | x-ray diffraction | A | — | — |
| 4JPM | Structure of SHV-1 beta-lactamase in complex with the 7-alkylidenecephalosporin DCM-1-10 at 1.14… | x-ray diffraction | A | — | — |
| 4JPM | Structure of shv-1 beta-lactamase in complex with the 7- alkylidenecephalosporin dcm-1-10 at 1.14… | x-ray diffraction | A | — | — |
| 4MBF | Crystal structure of Penam sulfone PSR-4-157 bound to SHV-1 beta-lactamase | x-ray diffraction | A | — | — |
| 4MBF | Crystal structure of penam sulfone psr-4-157 bound to shv-1 beta- lactamase | x-ray diffraction | A | — | — |
| 4MBH | Penam sulfone PSR-3-226 bound to E166A variant of SHV-1 beta-lactamase | x-ray diffraction | A | — | — |
| 4MBH | Penam sulfone psr-3-226 bound to E166A variant of shv-1 beta-lactamase | x-ray diffraction | A | — | — |
| 4MBK | Crystal structure of K234R inhibitor-resistant variant of SHV beta-lactamase in complex with SA2-13 | x-ray diffraction | A | — | — |
| 4MBK | Crystal structure of K234R inhibitor-resistant variant of shv beta- lactamase in complex with SA2-13 | x-ray diffraction | A | — | — |
| 4R3B | Crystal structure of SHV-1 b-lactamase in complex with 6b-(hydroxymethyl)penicillanic acid sulfone… | x-ray diffraction | A | — | — |
| 4R3B | Crystal structure of shv-1 B-lactamase in complex with 6B- (HYDROXYMETHYL)PENICILLANIC acid sulfone… | x-ray diffraction | A | — | — |
| 4ZAM | Crystal structure of SHV-1 beta-lactamase bound to avibactam | x-ray diffraction | A | — | — |
| 4ZAM | Crystal structure of shv-1 beta-lactamase bound to avibactam | x-ray diffraction | A | — | — |
3 records more on the page itself.
Ligands
Experiment against prediction
- 2G2W chain A against the predicted model P0AD64: TM-score 1.00, RMSD 0.36 Å
- 2G2W chain A against the predicted model P0AD64: TM-score 1.00, RMSD 0.36 Å
- 3N4I chain A against the predicted model P0AD64: TM-score 0.99, RMSD 0.45 Å
- 3N4I chain A against the predicted model P0AD64: TM-score 0.99, RMSD 0.45 Å
- 2G2U chain A against the predicted model P0AD64: TM-score 0.99, RMSD 0.45 Å
- 2G2U chain A against the predicted model P0AD64: TM-score 0.99, RMSD 0.45 Å
- 3C4P chain A against the predicted model P0AD64: TM-score 0.99, RMSD 0.47 Å
- 3C4P chain A against the predicted model P0AD64: TM-score 0.99, RMSD 0.47 Å
- 3C4O chain A against the predicted model P0AD64: TM-score 0.99, RMSD 0.48 Å
- 3C4O chain A against the predicted model P0AD64: TM-score 0.99, RMSD 0.48 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.