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Ligand · TSL

TSL · Trans-enamine intermediate of sulbactam

TSL, Trans-enamine intermediate of sulbactam (C8 H13 N O5 S, 235.2 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
TSL
Formula
C8 H13 N O5 S
Class
ligand
Structures
8
PDB entries
6

Binding sites

TSL in 8 structures; the first of them:

  • 6H2K · Structure of BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of… · TSL A501 · binds CYS69, SER70, ILE103, SER128, GLU168, PRO169, ASN172, ARG173 and 2 more
  • 6ITY · CTX-M-64 sulbactam complex · TSL A301 · binds CYS69, SER70, ASN104, SER130, ASN132, GLU166, PRO167, ASN170 and 3 more
  • 8ECF · Cryo structure of Mycobacterium tuberculosis beta lactamase microcrystals mixed with… · TSL A302 · binds CYS69, SER70, LYS73, SER102, ILE103, SER128, GLU168, PRO169 and 8 more
  • 6H2K · Structure of blac from mycobacterium tuberculosis bound to the trans- enamine adduct of… · TSL A501 · binds CYS69, SER70, ILE103, SER128, GLU168, PRO169, ASN172, ARG173 and 2 more
  • 6ITY · Ctx-M-64 sulbactam complex · TSL A301 · binds CYS69, SER70, ASN104, SER130, ASN132, GLU166, PRO167, ASN170 and 3 more
  • 6J2B · Ctx-M-64 beta-lactamase S130T sulbactam complex · TSL A301 · binds CYS69, SER70, ASN104, TYR105, ASN132, PRO167, ASN170, GLY236 and 2 more
  • 7A72 · Structure of G132S blac from mycobacterium tuberculosis bound to the trans-enamine adduct… · TSL A501 · binds CYS69, SER70, SER104, ILE105, SER130, GLU166, PRO167, ASN170 and 4 more
  • 7K8K · Beta-lactamase mixed with sulbactam, 60MS · TSL B301 · binds GLN109, CYS69, SER70, LYS73, ILE103, GLU168, PRO169, ASN172 and 2 more

Residues it binds most

SER 17, ASN 17, GLY 16, CYS 17, PRO 16, GLU 13, THR 11, ILE 11, GLN 6, ARG 5 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • ACT · Acetate ion
  • AKR · Acrylic acid
  • PO4 · Phosphate ion
  • PEG · Di(hydroxyethyl)ether

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