UniProt P0AA25
Thioredoxin 1,Poly(U)-binding-splicing factor PUF60 (P0AA25)
Thioredoxin 1,Poly(U)-binding-splicing factor PUF60 (UniProt P0AA25): 92 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0AA25
- Protein
- Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
- Experimental structures
- 92
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 24 · 2 records with a druggable one
Structures
93 records of P0AA25 in the MolNFT archive: 92 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F6M | Crystal structure of a complex between thioredoxin reductase, thioredoxin, and the NADP+ analog… | x-ray diffraction | C, D, G, H | — | — |
| 1F6M | Crystal structure of a complex between thioredoxin reductase, thioredoxin, and the NADP+ analog… | x-ray diffraction | C, D, G, H | — | — |
| 1KEB | Crystal Structure of Double Mutant M37L,P40S E.coli Thioredoxin | x-ray diffraction | A, B | — | — |
| 1KEB | Crystal structure of double mutant M37L,P40S E.COLI thioredoxin | x-ray diffraction | A, B | — | — |
| 1SKR | T7 DNA Polymerase Complexed To DNA Primer/Template and ddATP | x-ray diffraction | B | — | — |
| 1SKR | T7 DNA polymerase complexed to DNA PRIMER/TEMPLATE and ddatp | x-ray diffraction | B | — | — |
| 1SKS | Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine… | x-ray diffraction | B | — | — |
| 1SKS | Binary 3' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a cis-syn thymine… | x-ray diffraction | B | — | — |
| 1SKW | Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn… | x-ray diffraction | B | — | — |
| 1SKW | Binary 3' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a disordered cis-syn… | x-ray diffraction | B | — | — |
| 1SL0 | Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn… | x-ray diffraction | B, D | — | — |
| 1SL0 | Ternary 3' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a disordered cis-syn… | x-ray diffraction | B, D | — | — |
| 1SL1 | Binary 5' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine… | x-ray diffraction | B | — | — |
| 1SL1 | Binary 5' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a cis-syn thymine… | x-ray diffraction | B | — | — |
| 1SL2 | Ternary 5' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine… | x-ray diffraction | B | — | — |
| 1SL2 | Ternary 5' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a cis-syn thymine… | x-ray diffraction | B | — | — |
| 1SRX | Three-dimensional structure of escherichia COLI thioredoxin-S2 to 2.8 ångströms resolution | x-ray diffraction | A | — | — |
| 1SRX | Three-dimensional structure of escherichia COLI thioredoxin-S2 to 2.8 ångströms resolution | x-ray diffraction | A | — | — |
| 1T8E | T7 DNA Polymerase Ternary Complex with dCTP at the Insertion Site. | x-ray diffraction | B | — | — |
| 1T8E | T7 DNA polymerase ternary complex with dctp at the insertion site. | x-ray diffraction | B | — | — |
| 1THO | Crystal structure of a mutant escherichia COLI thioredoxin with an arginine insertion in the active… | x-ray diffraction | A | — | — |
| 1THO | Crystal structure of a mutant escherichia COLI thioredoxin with an arginine insertion in the active… | x-ray diffraction | A | — | — |
| 1TK0 | T7 DNA polymerase ternary complex with 8 oxo guanosine and ddCTP at the insertion site | x-ray diffraction | B | — | — |
| 1TK0 | T7 DNA polymerase ternary complex with 8 oxo guanosine and ddctp at the insertion site | x-ray diffraction | B | — | — |
| 1TK5 | T7 DNA polymerase binary complex with 8 oxo guanosine in the templating strand | x-ray diffraction | B | — | — |
| 1TK5 | T7 DNA polymerase binary complex with 8 oxo guanosine in the templating strand | x-ray diffraction | B | — | — |
| 1TK8 | T7 DNA polymerase ternary complex with 8 oxo guanosine and dAMP at the elongation site | x-ray diffraction | B | — | — |
| 1TK8 | T7 DNA polymerase ternary complex with 8 oxo guanosine and damp at the elongation site | x-ray diffraction | B | — | — |
| 1TKD | T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site | x-ray diffraction | B | — | — |
| 1TKD | T7 DNA polymerase ternary complex with 8 oxo guanosine and dcmp at the elongation site | x-ray diffraction | B | — | — |
| 1TXX | Active-site variant of E.COLI thioredoxin | x-ray diffraction | A | — | — |
| 1TXX | Active-site variant of E.COLI thioredoxin | x-ray diffraction | A | — | — |
| 1X9M | T7 DNA polymerase in complex with an N-2-acetylaminofluorene-adducted DNA | x-ray diffraction | B | — | — |
| 1X9M | T7 DNA polymerase in complex with an N-2- acetylaminofluorene-adducted DNA | x-ray diffraction | B | — | — |
| 1X9S | T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene… | x-ray diffraction | B | — | — |
| 1X9S | T7 DNA polymerase in complex with a PRIMER/TEMPLATE DNA containing a disordered N-2 aminofluorene… | x-ray diffraction | B | — | — |
| 1X9W | T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene… | x-ray diffraction | B | — | — |
| 1X9W | T7 DNA polymerase in complex with a PRIMER/TEMPLATE DNA containing a disordered N-2 aminofluorene… | x-ray diffraction | B | — | — |
| 1XOA | Thioredoxin (oxidized disulfide form), NMR, 20 structures | solution nmr | A | — | — |
| 1XOA | Thioredoxin (oxidized disulfide form), NMR, 20 structures | solution nmr | A | — | — |
| 1XOB | Thioredoxin (reduced dithio form), NMR, 20 structures | solution nmr | A | — | — |
| 1XOB | Thioredoxin (reduced dithio form), NMR, 20 structures | solution nmr | A | — | — |
| 1ZCP | Crystal Structure of a catalytic site mutant E. coli TrxA (CACA) | x-ray diffraction | A, B, C, D | — | — |
| 1ZCP | Crystal structure of a catalytic site mutant E. COLI trxa (caca) | x-ray diffraction | A, B, C, D | — | — |
| 1ZYQ | T7 DNA polymerase in complex with 8oG and incoming ddATP | x-ray diffraction | B | — | — |
| 1ZYQ | T7 DNA polymerase in complex with 8OG and incoming ddatp | x-ray diffraction | B | — | — |
| 2AJQ | Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity… | x-ray diffraction | B, I | — | — |
| 2AJQ | Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity… | x-ray diffraction | B, I | — | — |
| 2EIO | Design of Disulfide-linked Thioredoxin Dimers and Multimers Through Analysis of Crystal Contacts | x-ray diffraction | A, B, C, D | — | — |
| 2EIO | Design of disulfide-linked thioredoxin dimers and multimers through analysis of crystal contacts | x-ray diffraction | A, B, C, D | — | — |
| 2EIQ | Design of Disulfide-linked Thioredoxin Dimers and Multimers Through Analysis of Crystal Contacts | x-ray diffraction | A, B | — | — |
| 2EIQ | Design of disulfide-linked thioredoxin dimers and multimers through analysis of crystal contacts | x-ray diffraction | A, B | — | — |
| 2EIR | Design of Disulfide-linked Thioredoxin Dimers and Multimers Through Analysis of Crystal Contacts | x-ray diffraction | A, B, C, D | — | — |
| 2EIR | Design of disulfide-linked thioredoxin dimers and multimers through analysis of crystal contacts | x-ray diffraction | A, B, C, D | — | — |
| 2FCH | Crystal Structure of Thioredoxin Mutant G74S | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 2FCH | Crystal structure of thioredoxin mutant G74S | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 2FD3 | Crystal Structure of Thioredoxin Mutant P34H | x-ray diffraction | A, B | — | — |
| 2FD3 | Crystal structure of thioredoxin mutant P34H | x-ray diffraction | A, B | — | — |
| 2TIR | Crystal structure analysis of a mutant escherichia COLI thioredoxin in which lysine 36 is replaced… | x-ray diffraction | A | — | — |
| 2TIR | Crystal structure analysis of a mutant escherichia COLI thioredoxin in which lysine 36 is replaced… | x-ray diffraction | A | — | — |
33 records more on the page itself.
Ligands
- NA · Sodium ion · in 3 records
- 2CV · Hega-10 · in 2 records
- A3P · Adenosine-3'-5'-diphosphate · in 2 records
- BDP · beta-D-glucopyranuronic acid · in 2 records
- EVU · 4-[2-[4-(aminomethyl)phenyl]phenyl]piperazin-2-one · in 2 records
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · in 2 records
- H98 · ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide · in 1 record
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 2FCH chain A against the predicted model P0AA25: TM-score 0.99, RMSD 0.44 Å
- 2FCH chain A against the predicted model P0AA25: TM-score 0.99, RMSD 0.44 Å
- 2EIO chain A against the predicted model P0AA25: TM-score 0.99, RMSD 0.49 Å
- 2EIO chain A against the predicted model P0AA25: TM-score 0.99, RMSD 0.49 Å
- 2TRX chain A against the predicted model P0AA25: TM-score 0.98, RMSD 0.52 Å
- 2TRX chain A against the predicted model P0AA25: TM-score 0.98, RMSD 0.52 Å
- 6H7O chain E against the predicted model P0AA25: TM-score 0.98, RMSD 0.49 Å
- 6H7O chain E against the predicted model P0AA25: TM-score 0.98, RMSD 0.49 Å
- 2FCH chain D against the predicted model P0AA25: TM-score 0.98, RMSD 0.49 Å
- 2FCH chain D against the predicted model P0AA25: TM-score 0.98, RMSD 0.49 Å
Elsewhere
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