UniProt P0A9V1
Lipopolysaccharide export system ATP-binding protein LptB (P0A9V1)
Lipopolysaccharide export system ATP-binding protein LptB (UniProt P0A9V1), EC 3.6.3.-: 22 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 48 pockets. Binding sites, druggability and experiment…
- UniProt
- P0A9V1
- Protein
- Lipopolysaccharide export system ATP-binding protein LptB
- EC
- 3.6.3.-
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 48 · 6 records with a druggable one
Structures
23 records of P0A9V1 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4P31 | Crystal structure of a selenomethionine derivative of E. coli LptB in complex with ADP-Magensium | x-ray diffraction | A, B | — | — |
| 4P31 | Crystal structure of a selenomethionine derivative of E. COLI lptb in complex with ADP-magensium | x-ray diffraction | A, B | — | — |
| 4P32 | Crystal structure of E. coli LptB in complex with ADP-magnesium | x-ray diffraction | A, B | — | — |
| 4P32 | Crystal structure of E. COLI lptb in complex with ADP-magnesium | x-ray diffraction | A, B | — | — |
| 4P33 | Crystal structure of E. coli LptB-E163Q in complex with ATP-sodium | x-ray diffraction | A, B | — | — |
| 4P33 | Crystal structure of E. COLI lptb-E163Q in complex with ATP-sodium | x-ray diffraction | A, B | — | — |
| 6B89 | E. coli LptB in complex with ADP and novobiocin | x-ray diffraction | A, B | ADP, MG, NOV | 5 (best 0.85) |
| 6B89 | E. COLI lptb in complex with ADP and novobiocin | x-ray diffraction | A, B | ADP, MG, NOV | — |
| 6B8B | E. coli LptB in complex with ADP and a novobiocin derivative | x-ray diffraction | A | MG, CZJ, ADP | 1 (best 0.49) |
| 6B8B | E. COLI lptb in complex with ADP and a novobiocin derivative | x-ray diffraction | A | MG, CZJ, ADP | — |
| 6MBN | LptB E163Q in complex with ATP | x-ray diffraction | A, B | NA, ATP | 3 (best 0.67) |
| 6MBN | Lptb E163Q in complex with ATP | x-ray diffraction | A, B | NA, ATP | — |
| 6MGF | untagged, wild-type LptB in complex with ADP | x-ray diffraction | A | MG, ADP, CZJ | 1 (best 0.48) |
| 6MGF | Untagged, wild-type lptb in complex with ADP | x-ray diffraction | A | MG, ADP, CZJ | — |
| 6MHU | Nucleotide-free Cryo-EM Structure of E.coli LptB2FG Transporter | electron microscopy | A, B | — | 9 (best 0.68) |
| 6MHU | Nucleotide-free cryo-EM structure of E.COLI LPTB2FG transporter | electron microscopy | A, B | — | — |
| 6MHZ | Vanadate trapped Cryo-EM Structure of E.coli LptB2FG Transporter | electron microscopy | A, B | AOV | 10 (best 0.86) |
| 6MHZ | Vanadate trapped cryo-EM structure of E.COLI LPTB2FG transporter | electron microscopy | A, B | AOV | — |
| 6MI7 | Nucleotide-free Cryo-EM Structure of E.coli LptB2FGC | electron microscopy | A, B | — | 8 (best 0.68) |
| 6MI7 | Nucleotide-free cryo-EM structure of E.COLI LPTB2FGC | electron microscopy | A, B | — | — |
| 6MI8 | Cryo-EM Structure of vanadate-trapped E.coli LptB2FGC | electron microscopy | A, B | AOV | 10 (best 0.89) |
| 6MI8 | Cryo-EM structure of vanadate-trapped E.COLI LPTB2FGC | electron microscopy | A, B | AOV | — |
| P0A9V1 | AlphaFold monomer V2.0 prediction for lipopolysaccharide export system ATP-binding protein lptb… | predicted | A | — | 1 (best 0.48) |
Ligands
- ADP · Adenosine-5'-diphosphate · in 6 records
- MG · Magnesium ion · in 6 records
- AOV · Adp orthovanadate · in 4 records
- CZJ · (3S,5S,7S)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-ben zopyran-3-yl}tricyclo[3.3.1.1~3, 7~]decane-1-carboxamide · in 4 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- NA · Sodium ion · in 2 records
- NOV · Novobiocin · in 2 records
Experiment against prediction
- 4P31 chain B against the predicted model P0A9V1: TM-score 0.98, RMSD 0.82 Å
- 4P31 chain B against the predicted model P0A9V1: TM-score 0.98, RMSD 0.82 Å
- 4P32 chain B against the predicted model P0A9V1: TM-score 0.98, RMSD 0.82 Å
- 4P32 chain B against the predicted model P0A9V1: TM-score 0.98, RMSD 0.82 Å
- 4P32 chain A against the predicted model P0A9V1: TM-score 0.98, RMSD 0.91 Å
- 4P32 chain A against the predicted model P0A9V1: TM-score 0.98, RMSD 0.91 Å
- 4P31 chain A against the predicted model P0A9V1: TM-score 0.97, RMSD 0.97 Å
- 4P31 chain A against the predicted model P0A9V1: TM-score 0.97, RMSD 0.97 Å
- 6B89 chain A against the predicted model P0A9V1: TM-score 0.97, RMSD 1.01 Å
- 6B89 chain A against the predicted model P0A9V1: TM-score 0.97, RMSD 1.01 Å
Elsewhere
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