UniProt P0A7Z6
DNA-directed RNA polymerase subunit alpha (P0A7Z6)
DNA-directed RNA polymerase subunit alpha (UniProt P0A7Z6), EC 2.7.7.6: 52 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 200 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0A7Z6
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 52
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 200 · 37 records with a druggable one
Structures
53 records of P0A7Z6 in the MolNFT archive: 52 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4YG2 | X-ray crystal structur of Escherichia coli RNA polymerase sigma70 holoenzyme | x-ray diffraction | A, B, G, H | — | 9 (best 0.84) |
| 4YG2 | X-ray crystal structur of escherichia COLI RNA polymerase SIGMA70 holoenzyme | x-ray diffraction | A, B, G, H | — | 9 (best 0.84) |
| 5EZK | RNA polymerase model placed by Molecular replacement into X-ray diffraction map of DNA-bound RNA… | x-ray diffraction | A, B | — | 4 (best 0.83) |
| 5EZK | RNA polymerase model placed by molecular replacement into X-ray diffraction MAP of DNA-bound RNA… | x-ray diffraction | A, B | — | 4 (best 0.83) |
| 5TBZ | E. COLI RNA polymerase complexed with nusg | x-ray diffraction | A, B, F, G | — | 7 (best 0.82) |
| 5UI8 | structure of sigmaN-holoenzyme | x-ray diffraction | G, H | — | 9 (best 0.83) |
| 5UI8 | Structure of sigman-holoenzyme | x-ray diffraction | G, H | — | 9 (best 0.83) |
| 6AWB | Structure of 30S ribosomal subunit and RNA polymerase complex in non-rotated state | electron microscopy | 01, 02 | — | 3 (best 0.85) |
| 6AWC | Structure of 30S ribosomal subunit and RNA polymerase complex in rotated state | electron microscopy | 01, 02 | — | 1 (best 0.83) |
| 6AWD | Structure of 30S (S1 depleted) ribosomal subunit and RNA polymerase complex | electron microscopy | 01, 02 | — | 1 (best 0.80) |
| 6B6H | The cryo-EM structure of a bacterial class I transcription activation complex | electron microscopy | A, B, I | — | 4 (best 0.80) |
| 6B6H | The cryo-EM structure of a bacterial class I transcription activation complex | electron microscopy | A, B, I | — | 4 (best 0.80) |
| 6GOV | Structure of THE RNA POLYMERASE LAMBDA-BASED ANTITERMINATION COMPLEX | electron microscopy | U, V | — | 4 (best 0.84) |
| 6GOV | Structure of the RNA polymerase lambda-based antitermination complex | electron microscopy | U, V | — | 4 (best 0.84) |
| 6N62 | Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA | x-ray diffraction | A, B | — | 6 (best 0.81) |
| 6N62 | Escherichia COLI RNA polymerase SIGMA70-holoenzyme bound to upstream fork promoter DNA | x-ray diffraction | A, B | — | — |
| 6OMF | CryoEM structure of SigmaS-transcription initiation complex with activator Crl | electron microscopy | A, B | — | 4 (best 0.83) |
| 6OMF | Cryoem structure of sigmas-transcription initiation complex with activator crl | electron microscopy | A, B | — | — |
| 6PB4 | The E. coli class-II CAP-dependent transcription activation complex with de novo RNA transcript at… | electron microscopy | A, B | — | 5 (best 0.88) |
| 6PB4 | The E. COLI class-II cap-dependent transcription activation complex with de novo RNA transcript at… | electron microscopy | A, B | — | — |
| 6PB5 | The E. coli class-II CAP-dependent transcription activation complex at the state 1 architecture | electron microscopy | A, B | — | 5 (best 0.87) |
| 6PB5 | The E. COLI class-II cap-dependent transcription activation complex at the state 1 architecture | electron microscopy | A, B | — | — |
| 6PB6 | The E. coli class-II CAP-dependent transcription activation complex at the state 2 | electron microscopy | A, B | — | 5 (best 0.90) |
| 6PB6 | The E. COLI class-II cap-dependent transcription activation complex at the state 2 | electron microscopy | A, B | — | — |
| 6PMI | Sigm28-transcription initiation complex with specific promoter at the state 1 | electron microscopy | A, B | — | 5 (best 0.84) |
| 6PMI | SIGM28-transcription initiation complex with specific promoter at the state 1 | electron microscopy | A, B | — | — |
| 6PMJ | Sigm28-transcription initiation complex with specific promoter at the state 2 | electron microscopy | A, B | — | 6 (best 0.87) |
| 6PMJ | SIGM28-transcription initiation complex with specific promoter at the state 2 | electron microscopy | A, B | — | — |
| 6XH7 | CueR-TAC without RNA | electron microscopy | A, B | — | 6 (best 0.84) |
| 6XH7 | Cuer-tac without RNA | electron microscopy | A, B | — | — |
| 6XH8 | CueR-transcription activation complex with RNA transcript | electron microscopy | A, B | — | 6 (best 0.83) |
| 6XH8 | Cuer-transcription activation complex with RNA transcript | electron microscopy | A, B | — | — |
| 6XL5 | Cryo-EM structure of EcmrR-RNAP-promoter open complex (EcmrR-RPo) | electron microscopy | A, B | 1N7 | 5 (best 0.82) |
| 6XL5 | Cryo-EM structure of ecmrr-rnap-promoter open complex (ecmrr-rpo) | electron microscopy | A, B | 1N7 | — |
| 6XL9 | Cryo-EM structure of EcmrR-RNAP-promoter initial transcribing complex with 3-nt RNA transcript… | electron microscopy | A, B | — | 4 (best 0.80) |
| 6XL9 | Cryo-EM structure of ecmrr-rnap-promoter initial transcribing complex with 3-nt RNA transcript… | electron microscopy | A, B | — | — |
| 6XLJ | Cryo-EM structure of EcmrR-RNAP-promoter initial transcribing complex with 4-nt RNA transcript… | electron microscopy | A, B | 1N7 | 5 (best 0.81) |
| 6XLJ | Cryo-EM structure of ecmrr-rnap-promoter initial transcribing complex with 4-nt RNA transcript… | electron microscopy | A, B | 1N7 | — |
| 6XLL | Cryo-EM structure of E. coli RNAP-promoter initial transcribing complex with 5-nt RNA transcript… | electron microscopy | A, B | 1N7 | 5 (best 0.84) |
| 6XLL | Cryo-EM structure of E. COLI rnap-promoter initial transcribing complex with 5-nt RNA transcript… | electron microscopy | A, B | 1N7 | — |
| 6XLM | Cryo-EM structure of E.coli RNAP-DNA elongation complex 1 (RDe1) in EcmrR-dependent transcription | electron microscopy | A, B | 1N7 | 4 (best 0.84) |
| 6XLM | Cryo-EM structure of E.COLI rnap-DNA elongation complex 1 (RDE1) in ecmrr-dependent transcription | electron microscopy | A, B | 1N7 | — |
| 6XLN | Cryo-EM structure of E. coli RNAP-DNA elongation complex 2 (RDe2) in EcmrR-dependent transcription | electron microscopy | A, B | 1N7 | 7 (best 0.81) |
| 6XLN | Cryo-EM structure of E. COLI rnap-DNA elongation complex 2 (RDE2) in ecmrr-dependent transcription | electron microscopy | A, B | 1N7 | — |
| 8EG7 | Cryo-EM structure of pre-consensus elemental paused elongation complex | electron microscopy | G, H | 1N7 | 7 (best 0.82) |
| 8EG8 | Cryo-EM structure of consensus elemental paused elongation complex with a folded TL | electron microscopy | G, H | 1N7 | 6 (best 0.83) |
| 8EGB | Cryo-EM structure of consensus elemental paused elongation complex with an unfolded TL | electron microscopy | G, H | 1N7 | 7 (best 0.81) |
| 8EH8 | Cryo-EM structure of his-elemental paused elongation complex with a folded TL and a rotated RH-FL… | electron microscopy | G, H | — | 6 (best 0.81) |
| 8EH9 | Cryo-EM structure of his-elemental paused elongation complex with a folded TL and a rotated RH-FL… | electron microscopy | G, H | — | 6 (best 0.83) |
| 8EHA | Cryo-EM structure of his-elemental paused elongation complex with a folded TL and a rotated RH-FL… | electron microscopy | G, H | — | 5 (best 0.83) |
| 8EHF | Cryo-EM structure of his-elemental paused elongation complex with an unfolded TL (1) | electron microscopy | G, H | — | 4 (best 0.84) |
| 8EHI | Cryo-EM structure of his-elemental paused elongation complex with an unfolded TL (2) | electron microscopy | G, H | — | 6 (best 0.84) |
| P0A7Z6 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (P0A7Z6) | predicted | A | — | 3 (best 0.44) |
Ligands
- 1N7 · Chapso · in 13 records
Experiment against prediction
- 8EG7 chain H against the predicted model P0A7Z6: TM-score 0.97, RMSD 1.14 Å
- 8EHI chain H against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.25 Å
- 8EH8 chain H against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.31 Å
- 8EGB chain H against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.16 Å
- 8EHA chain H against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.31 Å
- 8EH9 chain H against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.34 Å
- 4YG2 chain B against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.18 Å
- 4YG2 chain B against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.18 Å
- 8EG8 chain H against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.19 Å
- 8EHF chain H against the predicted model P0A7Z6: TM-score 0.96, RMSD 1.32 Å
Elsewhere
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