UniProt P0A7Z4
DNA-directed RNA polymerase subunit alpha (P0A7Z4)
DNA-directed RNA polymerase subunit alpha (UniProt P0A7Z4), EC 2.7.7.6: 218 experimental structures on GenesisL1, 2 ligands bound, 311 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P0A7Z4
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 218
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 311 · 58 records with a druggable one
Structures
218 records of P0A7Z4 in the MolNFT archive: 218 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BDF | Structure of escherichia COLI RNA polymerase alpha subunit N-terminal domain | x-ray diffraction | A, B, C, D | — | — |
| 1BDF | Structure of escherichia COLI RNA polymerase alpha subunit N-terminal domain | x-ray diffraction | A, B, C, D | — | — |
| 1COO | The cooh-terminal domain of RNA polymerase alpha subunit | solution nmr | A | — | — |
| 1COO | The cooh-terminal domain of RNA polymerase alpha subunit | solution nmr | A | — | — |
| 1LB2 | Structure of the E. coli alpha C-terminal domain of RNA polymerase in complex with CAP and DNA | x-ray diffraction | B, E | — | — |
| 1LB2 | Structure of the E. COLI alpha C-terminal domain of RNA polymerase in complex with cap and DNA | x-ray diffraction | B, E | — | — |
| 1XS9 | A model of the ternary complex formed between mara, the alpha-ctd of RNA polymerase and DNA | solution nmr | D | — | — |
| 1XS9 | A model of the ternary complex formed between mara, the alpha-ctd of RNA polymerase and DNA | solution nmr | D | — | — |
| 2JZB | Solution structure of the complex between E.coli NusA-AR2 and RNAP-aCTD | solution nmr | A | — | — |
| 2JZB | Solution structure of the complex between E.COLI nusa-AR2 and rnap- actd | solution nmr | A | — | — |
| 3IYD | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex | electron microscopy | A, B | — | — |
| 3IYD | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex | electron microscopy | A, B | — | — |
| 3K4G | Crystal structure of E. coli RNA polymerase alpha subunit C-terminal domain | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3K4G | Crystal structure of E. COLI RNA polymerase alpha subunit C-terminal domain | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3LU0 | Molecular model of Escherichia coli core RNA polymerase | electron microscopy | A, B | — | — |
| 3LU0 | Molecular model of escherichia COLI core RNA polymerase | electron microscopy | A, B | — | — |
| 3N4M | E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA | x-ray diffraction | B, C | — | — |
| 3N4M | E. COLI RNA polymerase alpha subunit C-terminal domain in complex with cap and DNA | x-ray diffraction | B, C | — | — |
| 3N97 | RNA polymerase alpha C-terminal domain (E. coli) and sigma region 4 (T. aq. mutant) bound to… | x-ray diffraction | B, C | — | — |
| 3N97 | RNA polymerase alpha C-terminal domain (E. COLI) and sigma region 4 (T. aq. mutant) bound to… | x-ray diffraction | B, C | — | — |
| 4JK1 | X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine… | x-ray diffraction | A, B, F, G | — | — |
| 4JK1 | X-ray crystal structure of escherichia COLI SIGMA70 holoenzyme in complex with guanosine… | x-ray diffraction | A, B, F, G | — | — |
| 4JK2 | X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine… | x-ray diffraction | A, B, F, G | — | — |
| 4JK2 | X-ray crystal structure of escherichia COLI SIGMA70 holoenzyme in complex with guanosine… | x-ray diffraction | A, B, F, G | — | — |
| 4KMU | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin | x-ray diffraction | A, B, F, G | — | — |
| 4KMU | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with rifampin | x-ray diffraction | A, B, F, G | — | — |
| 4KN4 | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with… | x-ray diffraction | A, B, F, G | — | — |
| 4KN4 | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with… | x-ray diffraction | A, B, F, G | — | — |
| 4KN7 | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with… | x-ray diffraction | A, B, F, G | — | — |
| 4KN7 | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with… | x-ray diffraction | A, B, F, G | — | — |
| 4MEX | Crystal structure of Escherichia coli RNA polymerase in complex with salinamide A | x-ray diffraction | A, B, G, H | — | — |
| 4MEX | Crystal structure of escherichia COLI RNA polymerase in complex with salinamide a | x-ray diffraction | A, B, G, H | — | — |
| 4MEY | Crystal structure of Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | A, B, G, H | — | — |
| 4MEY | Crystal structure of escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | A, B, G, H | — | — |
| 4ZH2 | Crystal structure of Escherichia coli RNA polymerase in complex with CBR703 | x-ray diffraction | A, B, G, H | — | 8 (best 0.83) |
| 4ZH2 | Crystal structure of escherichia COLI RNA polymerase in complex with CBR703 | x-ray diffraction | A, B, G, H | — | — |
| 4ZH3 | Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br | x-ray diffraction | A, B, G, H | — | 7 (best 0.84) |
| 4ZH3 | Crystal structure of escherichia COLI RNA polymerase in complex with CBRH16-br | x-ray diffraction | A, B, G, H | — | — |
| 4ZH4 | Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 | x-ray diffraction | A, B, G, H | — | 6 (best 0.84) |
| 4ZH4 | Crystal structure of escherichia COLI RNA polymerase in complex with CBRP18 | x-ray diffraction | A, B, G, H | — | — |
| 5CIZ | E. COLI RNA polymerase alpha subunit ctd in complex with cap and DNA: A(5)-tract binding site for… | x-ray diffraction | B | — | — |
| 5IPL | SigmaS-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | A, B | — | — |
| 5IPL | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | A, B | — | — |
| 5IPM | SigmaS-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | A, B | — | — |
| 5IPM | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | A, B | — | — |
| 5IPN | SigmaS-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | A, B | — | 6 (best 0.79) |
| 5IPN | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | A, B | — | — |
| 5MS0 | pseudo-atomic model of the RNA polymerase lambda-based antitermination complex solved by cryo-EM | electron microscopy | A, B | — | — |
| 5MS0 | Pseudo-atomic model of the RNA polymerase lambda-based antitermination complex solved by cryo-EM | electron microscopy | A, B | — | — |
| 5MY1 | E. coli expressome | electron microscopy | V, W | — | — |
| 5MY1 | E. COLI expressome | electron microscopy | V, W | — | — |
| 5NSR | Cryo-EM structure of RNA polymerase-sigma54 holo enzyme with promoter DNA closed complex | electron microscopy | A, B | — | 4 (best 0.84) |
| 5NSR | Cryo-EM structure of RNA polymerase-SIGMA54 holo enzyme with promoter DNA closed complex | electron microscopy | A, B | — | — |
| 5NSS | Cryo-EM structure of RNA polymerase-SIGMA54 holoenzyme with promoter DNA and transcription… | electron microscopy | A, B | — | — |
| 5NWT | Crystal Structure of Escherichia coli RNA polymerase - Sigma54 Holoenzyme complex | x-ray diffraction | A, B | — | 5 (best 0.84) |
| 5NWT | Crystal structure of escherichia COLI RNA polymerase - SIGMA54 holoenzyme complex | x-ray diffraction | A, B | — | — |
| 5UAC | Escherichia coli RNA polymerase and Rifampin complex, wild-type | x-ray diffraction | A, B, G, H | — | — |
| 5UAC | Escherichia COLI RNA polymerase and rifampin complex, wild-type | x-ray diffraction | A, B, G, H | — | — |
| 5UAG | Escherichia coli RNA polymerase mutant - RpoB D516V | x-ray diffraction | A, B, G, H | — | — |
| 5UAG | Escherichia COLI RNA polymerase mutant - rpob D516V | x-ray diffraction | A, B, G, H | — | — |
158 records more on the page itself.
Ligands
Elsewhere
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