UniProt P0A725

UDP-3-O-acyl-N-acetylglucosamine deacetylase (P0A725)

UDP-3-O-acyl-N-acetylglucosamine deacetylase (UniProt P0A725), EC 3.5.1.108: 1 experimental structure and 1 predicted model on GenesisL1, 2 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction…

UniProt: P0A725
Protein: UDP-3-O-acyl-N-acetylglucosamine deacetylase
EC: 3.5.1.108
Experimental structures: 1
Predicted models: 1
Ligands: 2
Pockets: 5 · 2 records with a druggable one

Structures

2 records of P0A725 in the MolNFT archive: 1 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7PHJ	LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of…	x-ray diffraction	A	ZN, 7PX	2 (best 0.68)
P0A725	AlphaFold monomer V2.0 prediction for udp-3-O-acyl-N- acetylglucosamine deacetylase (P0A725)	predicted	A	—	3 (best 0.65)

Ligands

7PX · (2~{R},4~{R})-4-[[(2~{S},4~{S})-4-fluoranylpyrrolidin-2-yl]carbonylamino]-1-(2-methylpropanoyl)-~{N}-[[4-(2-phenylethynyl)phenyl]methyl]pyrrolidine-2-carboxamide · in 1 record
ZN · Zinc ion · in 1 record

Experiment against prediction

7PHJ chain A against the predicted model P0A725: TM-score 0.99, RMSD 0.69 Å

Elsewhere

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