UniProt P0A720
Protein (thymidylate kinase) (P0A720)
Protein (thymidylate kinase) (UniProt P0A720), EC 2.7.4.9: 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A720
- Protein
- Protein (thymidylate kinase)
- EC
- 2.7.4.9
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 2 · 1 record with a druggable one
Structures
5 records of P0A720 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4TMK | Complex of E. COLI thymidylate kinase with the bisubstrate inhibitor TP5A | x-ray diffraction | A | — | — |
| 4TMK | Complex of E. COLI thymidylate kinase with the bisubstrate inhibitor TP5A | x-ray diffraction | A | — | — |
| 5TMP | Complex of E. COLI thymidylate kinase with the bisubstrate inhibitor AZTP5A | x-ray diffraction | A | Z5A | 2 (best 0.61) |
| 5TMP | Complex of E. COLI thymidylate kinase with the bisubstrate inhibitor AZTP5A | x-ray diffraction | A | Z5A | — |
| P0A720 | AlphaFold monomer V2.0 prediction for thymidylate kinase (P0A720) | predicted | A | — | — |
Ligands
- Z5A · P1-(5'-adenosyl)p5-(5'-(3'azido-3'-deoxythymidyl)) pentaphosphate · in 2 records
Experiment against prediction
- 5TMP chain A against the predicted model P0A720: TM-score 1.00, RMSD 0.27 Å
- 5TMP chain A against the predicted model P0A720: TM-score 1.00, RMSD 0.27 Å
- 4TMK chain A against the predicted model P0A720: TM-score 1.00, RMSD 0.30 Å
- 4TMK chain A against the predicted model P0A720: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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