UniProt P0A6A8
Acyl carrier protein (P0A6A8)
Acyl carrier protein (UniProt P0A6A8): 52 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A6A8
- Protein
- Acyl carrier protein
- Experimental structures
- 52
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 70 · 15 records with a druggable one
Structures
53 records of P0A6A8 in the MolNFT archive: 52 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ACP | Refinement of the NMR structures for acyl carrier protein with scalar coupling data | solution nmr | A | — | — |
| 1ACP | Refinement of the NMR structures for acyl carrier protein with scalar coupling data | solution nmr | A | — | — |
| 1L0H | Crystal structure of butyryl-acp from E.COLI | x-ray diffraction | A | — | — |
| 1L0H | Crystal structure of butyryl-acp from E.COLI | x-ray diffraction | A | — | — |
| 1L0I | Crystal structure of butyryl-ACP I62M mutant | x-ray diffraction | A | — | — |
| 1L0I | Crystal structure of butyryl-acp I62M mutant | x-ray diffraction | A | — | — |
| 1T8K | Crystal Structure of apo acyl carrier protein from E. coli | x-ray diffraction | A | — | — |
| 1T8K | Crystal structure of apo acyl carrier protein from E. COLI | x-ray diffraction | A | — | — |
| 2FAC | Crystal structure of E. coli hexanoyl-ACP | x-ray diffraction | A, B | — | — |
| 2FAC | Crystal structure of E. COLI hexanoyl-acp | x-ray diffraction | A, B | — | — |
| 2FAD | Crystal structure of E. coli heptanoyl-ACP | x-ray diffraction | A, B | — | — |
| 2FAD | Crystal structure of E. COLI heptanoyl-acp | x-ray diffraction | A, B | — | — |
| 2FAE | Crystal structure of E. coli decanoyl-ACP | x-ray diffraction | A, B | — | — |
| 2FAE | Crystal structure of E. COLI decanoyl-acp | x-ray diffraction | A, B | — | — |
| 2FHS | Structure of Acyl Carrier Protein Bound to FabI, the Enoyl Reductase from Escherichia Coli | x-ray diffraction | C | — | — |
| 2FHS | Structure of acyl carrier protein bound to fabi, the enoyl reductase from escherichia COLI | x-ray diffraction | C | — | — |
| 2K92 | Structural modification of acyl carrier protein by butyryl group | solution nmr | A | — | — |
| 2K92 | Structural modification of acyl carrier protein by butyryl group | solution nmr | A | — | — |
| 2K93 | Structural modification of acyl carrier protein by butyryl group | solution nmr | A | — | — |
| 2K93 | Structural modification of acyl carrier protein by butyryl group | solution nmr | A | — | — |
| 2K94 | Structural modification of acyl carrier protein by butyryl group | solution nmr | A | — | — |
| 2K94 | Structural modification of acyl carrier protein by butyryl group | solution nmr | A | — | — |
| 3EJB | Crystal Structure of P450BioI in complex with tetradecanoic acid ligated Acyl Carrier Protein | x-ray diffraction | A, C, E, G | — | — |
| 3EJB | Crystal structure of P450BIOI in complex with tetradecanoic acid ligated acyl carrier protein | x-ray diffraction | A, C, E, G | — | — |
| 3EJD | Crystal Structure of P450BioI in complex with hexadec-9Z-enoic acid ligated Acyl Carrier Protein | x-ray diffraction | A, C, E, G | — | — |
| 3EJD | Crystal structure of P450BIOI in complex with hexadec-9Z-enoic acid ligated acyl carrier protein | x-ray diffraction | A, C, E, G | — | — |
| 3EJE | Crystal Structure of P450BioI in complex with octadec-9Z-enoic acid ligated Acyl Carrier Protein | x-ray diffraction | A, C, E, G | — | — |
| 3EJE | Crystal structure of P450BIOI in complex with octadec-9Z-enoic acid ligated acyl carrier protein | x-ray diffraction | A, C, E, G | — | — |
| 5USR | Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms | x-ray diffraction | I, J, K, L | 8Q1 | 11 (best 0.75) |
| 5USR | Crystal structure of human NFS1-ISD11 in complex with E. COLI acyl- carrier protein at 3.09… | x-ray diffraction | I, J, K, L | 8Q1 | — |
| 6OKC | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C12-crypto… | x-ray diffraction | C, D | MRJ | — |
| 6OKC | Crosslinked crystal structure of type II fatty acid synthase ketosynthase, fabb, and C12-crypto… | x-ray diffraction | C, D | MRJ | — |
| 6OKF | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16-crypto… | x-ray diffraction | C, D | MRJ | 5 (best 0.77) |
| 6OKF | Crosslinked crystal structure of type II fatty acid synthase ketosynthase, fabb, and C16-crypto… | x-ray diffraction | C, D | MRJ | — |
| 6OKG | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C16-crypto… | x-ray diffraction | B | MU4 | 2 (best 0.61) |
| 6OKG | Crosslinked crystal structure of type II fatty acid synthase ketosynthase, fabf, and C16-crypto… | x-ray diffraction | B | MU4 | — |
| 6OLT | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C12-crypto… | x-ray diffraction | B | MRJ | 1 (best 0.63) |
| 6OLT | Crosslinked crystal structure of type II fatty acid synthase ketosynthase, fabf, and C12-crypto… | x-ray diffraction | B | MRJ | — |
| 6W98 | Single-Particle Cryo-EM Structure of Arabinofuranosyltransferase AftD from Mycobacteria | electron microscopy | B | PNS | 2 (best 0.73) |
| 6W98 | Single-particle cryo-EM structure of arabinofuranosyltransferase aftd from mycobacteria | electron microscopy | B | PNS | — |
| 7L4E | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C16:1-crypto… | x-ray diffraction | B | MU4 | 2 (best 0.61) |
| 7L4E | Crosslinked crystal structure of type II fatty acid synthase ketosynthase, fabf, and C16:1-crypto… | x-ray diffraction | B | MU4 | — |
| 7L4L | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C8-crypto Acyl… | x-ray diffraction | C, D | DYF | 7 (best 0.77) |
| 7L4L | Crosslinked crystal structure of type II fatty acid synthase ketosynthase, fabf, and C8-crypto acyl… | x-ray diffraction | C, D | DYF | — |
| 8PK8 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | C | 8Q1 | 3 (best 0.74) |
| 8PK9 | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | C | 8Q1 | 4 (best 0.74) |
| 8PKA | Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide… | electron microscopy | C | 8Q1 | 3 (best 0.74) |
| 8RMC | Structure of the FDX2-bound core ISC complex (proximal conformation) | electron microscopy | C, G | 8Q1 | 6 (best 0.74) |
| 8RMD | Structure of the FDX2-bound core ISC complex (distal conformation) | electron microscopy | C, G | 8Q1 | 6 (best 0.74) |
| 8RME | Structure of the core ISC complex under turnover conditions (frataxin-bound) | electron microscopy | C, G | 8Q1 | 6 (best 0.76) |
| 8RMF | Structure of the core ISC complex under turnover conditions (FDX2-bound in proximal conformation) | electron microscopy | C, G | 8Q1 | 6 (best 0.75) |
| 8RMG | Structure of the core ISC complex under turnover conditions (FDX2-bound in distal conformation) | electron microscopy | C, G | 8Q1 | 6 (best 0.74) |
| P0A6A8 | AlphaFold monomer V2.0 prediction for acyl carrier protein (P0A6A8) | predicted | A | — | — |
Ligands
- 8Q1 · S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate · in 10 records
- MRJ · N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide · in 6 records
- MU4 · N-[2-(hexadecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3, 3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide · in 4 records
- DYF · [(3~{R})-2,2-dimethyl-4-[[3-[2-[[(~{E})-oct-2-enoyl]amino]ethylamino]-3-oxidanylidene-propyl]amino]-3-oxidanyl-4-oxidanylidene-butyl] dihydrogen phosphate · in 2 records
- PNS · 4'-phosphopantetheine · in 2 records
Experiment against prediction
- 7L4L chain D against the predicted model P0A6A8: TM-score 0.98, RMSD 0.47 Å
- 7L4L chain D against the predicted model P0A6A8: TM-score 0.98, RMSD 0.47 Å
- 1L0I chain A against the predicted model P0A6A8: TM-score 0.97, RMSD 0.89 Å
- 1L0I chain A against the predicted model P0A6A8: TM-score 0.97, RMSD 0.89 Å
- 7L4E chain B against the predicted model P0A6A8: TM-score 0.97, RMSD 0.60 Å
- 7L4E chain B against the predicted model P0A6A8: TM-score 0.97, RMSD 0.60 Å
- 6OKC chain D against the predicted model P0A6A8: TM-score 0.97, RMSD 0.69 Å
- 6OKC chain D against the predicted model P0A6A8: TM-score 0.97, RMSD 0.69 Å
- 6OKG chain B against the predicted model P0A6A8: TM-score 0.97, RMSD 0.62 Å
- 6OKG chain B against the predicted model P0A6A8: TM-score 0.97, RMSD 0.62 Å
Elsewhere
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