UniProt P0A546
Dihydrofolate reductase (P0A546)
Dihydrofolate reductase (UniProt P0A546), EC 1.5.1.3: 22 experimental structures on GenesisL1, 12 ligands bound, 30 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P0A546
- Protein
- Dihydrofolate reductase
- EC
- 1.5.1.3
- Experimental structures
- 22
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 30 · 15 records with a druggable one
Structures
22 records of P0A546 in the MolNFT archive: 22 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DF7 | Dihydrofolate reductase of mycobacterium tuberculosis complexed with NADPH and methotrexate | x-ray diffraction | A | SO4, NDP, MTX | 1 (best 0.71) |
| 1DF7 | Dihydrofolate reductase of mycobacterium tuberculosis complexed with NADPH and methotrexate | x-ray diffraction | A | SO4, NDP, MTX | 1 (best 0.71) |
| 1DG5 | Dihydrofolate reductase of mycobacterium tuberculosis complexed with NADPH and trimethoprim | x-ray diffraction | A | NDP, TOP | 1 (best 0.68) |
| 1DG5 | Dihydrofolate reductase of mycobacterium tuberculosis complexed with NADPH and trimethoprim | x-ray diffraction | A | NDP, TOP | 1 (best 0.68) |
| 1DG7 | Dihydrofolate reductase of mycobacterium tuberculosis complexed with NADPH and 4-bromo WR99210 | x-ray diffraction | A | WRB, NDP | 1 (best 0.70) |
| 1DG7 | Dihydrofolate reductase of mycobacterium tuberculosis complexed with NADPH and 4-bromo WR99210 | x-ray diffraction | A | WRB, NDP | 1 (best 0.70) |
| 1DG8 | Dihydrofolate reductase of mycobacterium tuberculosis complexed with NADPH | x-ray diffraction | A | NDP | 1 (best 0.71) |
| 1DG8 | Dihydrofolate reductase of mycobacterium tuberculosis complexed with NADPH | x-ray diffraction | A | NDP | 1 (best 0.71) |
| 2CIG | Dihydrofolate reductase from Mycobacterium tuberculosis inhibited by the acyclic 4R isomer of… | x-ray diffraction | A | 1DG, SO4 | 1 (best 0.71) |
| 2CIG | Dihydrofolate reductase from mycobacterium tuberculosis inhibited by the acyclic 4R isomer of… | x-ray diffraction | A | — | — |
| 4KL9 | Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in the space group C2 | x-ray diffraction | A | NDP | 1 (best 0.73) |
| 4KL9 | Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in the space group C2 | x-ray diffraction | A | — | — |
| 4KLX | Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in an open… | x-ray diffraction | A, B | ATR, ETE | 4 (best 0.67) |
| 4KLX | Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in an open… | x-ray diffraction | A, B | — | — |
| 4KM0 | Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A, B | CP6, ATR | 3 (best 0.66) |
| 4KM0 | Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in complex with… | x-ray diffraction | A, B | — | — |
| 4KM2 | Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open… | x-ray diffraction | A, B | ATR, TOP | 5 (best 0.62) |
| 4KM2 | Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in an open… | x-ray diffraction | A, B | — | — |
| 4KNE | Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A, B | 1CY, ATR | 3 (best 0.66) |
| 4KNE | Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in complex with… | x-ray diffraction | A, B | — | — |
| 4M2X | Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ) | x-ray diffraction | A, C, E, G | NDP, TMQ, PO4 | 5 (best 0.76) |
| 4M2X | Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (tmq) | x-ray diffraction | A, C, E, G | — | — |
Ligands
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 10 records
- ATR · 2'-monophosphoadenosine-5'-diphosphate · in 4 records
- SO4 · Sulfate ion · in 3 records
- TOP · Trimethoprim · in 3 records
- MTX · Methotrexate · in 2 records
- WRB · 1-[3-(4-bromo-phenoxy)-propoxy]-6,6-dimethyl-1.6-dihydro-[1,3,5]triazine-2,4-diamine · in 2 records
- 1CY · 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine · in 1 record
- 1DG · (4R)-isonicotinic-acetyl-nicotinamide-adenine dinucleotide · in 1 record
- CP6 · 5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine · in 1 record
- ETE · 2-{2-[2-2-(methoxy-ethoxy)-ethoxy]-ethoxy}-ethanol · in 1 record
- PO4 · Phosphate ion · in 1 record
- TMQ · Trimetrexate · in 1 record
Elsewhere
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